NBME Answers : jotajota94's page

Welcome to jotajota94’s page.
Contributor score: 13

Comments ...

-8 (nbme24#47)

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A dgoo wya to ihknt obatu shti is taht agniiteonsn II si eprnste at eht ANGII oetrpecsr. fI uoy vige na nisengntoia perotcer obcerlk schu as aslaor.tn sith illw ileascdp eht setgnoiinna II prentes ni het terorse.cp shut rigsainenc hte slveel of ioientngsan II ni surem.

+1 (nbme24#15)

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cndciinee = enmrub of enw s/cesa nwe a+secs opiantloup at .sikr wne cesa=s 025. lpeoeP at rski ttah aeyr 5050 inlicn(ugd nwe s.eacs In neo potni htey erwe a oopptaluni ta k)irs 52/0 05=05 .%94

-6 (nbme22#48)

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I nthik teh eky to utgsdianndnre ihst tniuoesq is tath teh oby has aboev aeegvar .eniteiLhg htp attlesmusi eht eerasel fo GH (hgnom/elc./.0wbd.wp/8t1is:2b1n/m522uinv.hwptlin drhCe) hwti iCnhusg mserodyn vahe tosrh eturtsa ed/93winwnt3wmgnm.p5t6v/lsb61b.ui7ohp:hc/./.innlus )i iitshbni HG tcensireo /mnb.t/ih/nnpCwr2/wichg4t:wl5/1atPlc/..m6eiM6vp.cssoI ) ihnkt ttah btoh a hhgi ralocic tedi in tasf dan eolgusc acn aekm uyo fat os you nca enmleiiat seoth ernwsa csho.eci

+14 (nbme20#1)

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eUs eht irWyenabHe-dgr uqtoaeni

eTka teh sarequ troo fo 01/60,1 nda taht ilwl veig uoy hte eufcqeynr fo eth eiscsvree llaeel = 4/1.0
ulaCclaet teh eqycnrefu fo het intmadno leleal with =1,+qp hhwic is p= 0.7.95
hyeT aer ntleigl ouy ot cltalaceu teh eqrceunyf fo teh ssdeaei ,resarcir hiwch is ihwt hte iunaqeot q2.p
yeTh awtn noyl hte aeiesds crrriaes in cihwh eeiltnod is nepret.s To uaclatecl this, esu hte q aelvu )0/(14 nad pimlytul yb %80 in htis sludho ievg uyo .0.20
lylFan,i llucctaae fro 22q P )90).(=.00752( 0.04 = 15.2/

yex Nice! ...and we are supposed to read the stem and do all this in a minute or so? :-/ +22

charcot_bouchard Allele frequency 1/40. so carrier freq 1/20. 80% of 1/20 is 1/25 (80/100 x 1/20) +14

dickass Ah feck, 2pq got me +

hello_planet A handy shortcut for Hardy-Weinberg is that you generally can assume p ~= 1 if q if fairly low. It also tends to be easier to work in fractions if the answer choices are in fractions so you don't have to bounce back and forth between fractions and decimals. So with that, you send up with 2pq = 2 * 1 * 1/50 = 2/50 = 1/25. +4

-8 (nbme20#10)

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nWhe unajcetgdo briuinbil )(CB is sels d,an %03 of ttaol r;&bi-btnl-iigu-- acsneredi eht rcdtnpooiu of ueoangcjtndu buriibiln ro esdaeerdc kt.aepu soyHmlise is eth plsobsie wnsear ei.occh

BC si %%035-0 irbhieiipemlrnyamubix- E(.x tpsHeatii or ACho)olc lBl si emro than 05% &-g-t; tOiucnobrst (tairn or tcahatei)exrp

+5 (nbme21#5)

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PAD lwsfo omrf taoar ot playurmon rtarye egcrsinaed Toerarfoheteaed.l rf aacicdr uuttop sniarcees

seagull doesnt pre-load also decrease which would drop the C.O.? +

hungrybox @seagull I think it would increase preload b/c more blood is going into the pulmonary arteries -> lungs -> pulmonary veins -> eventually more blood in left atrium/ventricle -> inc preload +50

+3 (nbme21#42)

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gihH ucsoegl delsa to omre slnunii niotrpodcu in het utesf llc(ear ahtt eht onomerh ilinnsu is )aaloicbn ;--t&-g eagrl efsut gz&9b,o1;t(---l) ploebmrs in rbol.a

tinydoc I thought that was technically a problem with the fetus and wasnt considered an obstetric complication. +3

Subcomments ...

submitted by radshopeful(17),

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irhocnc dikyen ssaedie -;gt&- ceseddare EPO t;g--& dsreedcae hhmoitctinrareocc dkyien seesaid -t-g;& deerdeasc 4O-P neortexci -tg;-& nirsdaece PrhiHoT ccn ednyik sdaisee -&tg-; ddeecresa 5,12 iDyhivdodtr lcl(triai)co -&t-g; cerdnseai HPT

jotajota94 she is also volume overloaded. more fluid leads to a decrease in Hematocrit. +5

h0odtime I thought PTH increases 1-alpha-hydroxylase which increases levels of 1 ,25? +1

batmane it's supposed to in the setting of proper kidney fxn +2

h0odtime Whoops +1

avocadotoast The decrease in GFR leads to decreased delivery of 25 dihydro vit D to the PCT and the decrease in functional renal mass limits production of 1a-hydroxylase. The increase in PO4 also stimulates FGF-23 from bone, which inhibits PO4 reabsorption and 1a-hydroxylase. +1

submitted by beeip(123),

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hsTi has nbee a tuhog otcnepc for em to ge,t btu I nkhit m'I lfainly r:teeh

hTe tsme si eigsbcndri rirapmy aaedrln iycnin,ciufsef ro nss'dodiA.

HATC is ingbe rovprcee-dodu ot tsmlautie eth rnasadle ot reopcdu ,cotloris but etyh 'anct sdre,pno heiter edu to yohtrap or siednotrctu (B,T ueaimtomn:u ,DR4 .ect)
The ritsf 31 animo acids of AHCT nca eb edalecv to fmro -HMSα, hicwh salsiuttem ,nmltoeayecs sugnica iimyhpgntntpaeeor

jotajota94 Good job! Also, cortisol is involved in maintaining blood pressure. which was decreased in the patient. +7

tinydoc Decreased Na and increase K+ --- Hypoaldosteronisim Hypoglycemia, and hypotension --- Hypocortisolism so the adrenals arent working ---- adrenal Insufficiency the Hyperpigmentation comes from the increase ACTH as ACTH is from Proopiomelanocorticotropin. SO - increased ACTH also increases a -MSH ---> Hyper pigmentation. +10

hungrybox thank u for this answer +

bilzcop Ugh! I misread the question and chose ACTH :( +3

cienfuegos @bilzcop: same +

cienfuegos @bilzcop: let's never do it again, k? +1

maxillarythirdmolar Why does this patient have elevated BUN and creatinine?? +2

lovebug @ maxillaryhidmolar > I don't know exactly. but maybe.. Low hypo-adlo -> our body lose water -> hypo-volemia -> Decreased GFR -> Increased Cr,BUN. If I'm wrong. please correct me. +

submitted by wasabilateral(40),

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I nkhti ti ahs meoingths to od hiwt gyilcne eud( ot sti lmasl eszi ti nca fti ni amny pcsale weehr hoter aionm csdai can otn adn nehec it oevsdpir ault“urtrcs cpnca”smtoes ot teh eanlocgl, e.i. utp a knik in hte lhapa xil).he If neclygi si sicpmlaed by eisgmhtno ,slee I d’nto ktinh opcnloa-gler can ormf tsi trrccoe ncdyesaro rsuetur.ct

jotajota94 True! also, glycine is 1/3 of collagen alfa chains, so it makes sense that substitution with alanine (which is much bigger) would lead to disruption in the alpha helix formation. +

thepacksurvives Glycine is small and bendy, which allows it to form the fibrils for the triple helix +

brasel Also in general (FA 2018 pg 50) OI is from problems forming the triple helix which is secondary structure. Fortunately, they gave us something to reason with in the question (Gly->Ala) +2

submitted by wasabilateral(40),

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I hkitn ti ahs hiotmgnes to do twhi neyiclg ud(e ot sti almsl eisz it cna fti ni ymna eaclps eerhw oreht mnaoi sciad anc ont nad eecnh it svieprdo sarruu“tctl s”nctmposeca to eth ollcneg,a .ei. tup a nkki in the plaah x).eihl fI englciy si cldmspaie yb mtsihgeon e,sel I ont’d ntkhi clploa-eogrn nac mrfo its crorcet rcanodeys res.tcurtu

jotajota94 True! also, glycine is 1/3 of collagen alfa chains, so it makes sense that substitution with alanine (which is much bigger) would lead to disruption in the alpha helix formation. +

thepacksurvives Glycine is small and bendy, which allows it to form the fibrils for the triple helix +

brasel Also in general (FA 2018 pg 50) OI is from problems forming the triple helix which is secondary structure. Fortunately, they gave us something to reason with in the question (Gly->Ala) +2