Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.
The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype
hsiT sha to do wtih ontirn cpnigli.s eRmbreme GT.GA ihsT iatoumnt iunedcd an AG rcelso hrwee it swa esopdpsu to eb, os esom of ahtt rniont sujt ebecam na .enox
I nredeteirpt uqee"esnc igounrndurs rsfit wto oxnes of egne" - ot name they msut be ikagltn oautb tsin.onr Terhe fo the sarenw cihesoc tnd'o eavh cuhm to do thiw nonst.ri
hatt amy not be ira tt,hig utb elhps arwnro d.wno Aols wniongk emos -asaetiBlahms si edu to rnaiasvt ni broanlam slngipic lhesp. F(A 0192 pg )43
lsao emrremeb taht seta-aiasBhml si edu ot ntiop oniastumt in slcpie iests adn mproorte qecueessn F(19A 1.)p0g4 If yuo certea a miotutan ni a peclis tise uyo iwll lrysue essm pu het cectorr mRAN needde ot maek a ctfalounni Blbnoig- itonp.re Ttah is owh I aerdnesw the tnoqeui.s
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$279$49sA edsbirdce in teh nisqeout mt,se sith uatntmio usrocc nwtiih an ornint (a gnee tneegsm ihhwc is racndisbrte ;tR]ANDA&N[-g ubt ont nsd)alter.ta ARN lpiingsc ezmny)(se bgar ANR dna oo“pl i;”t an rnonit si tuc tou adn het oesxn on irtehe seid of teh nrnoti aer a,jdnoide leki t:hsi
o——oenrxe1t2nxonin t=g;& eoxn2xe—on1
Tlciapy,ly this nslgpcii ucoscr ta hte evyr edges fo teh tionrn wta(h I deednot wthi eht ”“— crerhcta).a tBu ni rou esca, a otiumtan hiwitn teh ntionr si isnguca RAN ciglnspi eynzme ot enicrgezo a enw i:tes eth persilc stcu winthi teh tonnri si(tdnea fo at het vrye dege, as it .)oshdul o,S ew gte hetgomnis htat klsoo ikel ihs:t
t21xoennrien—o—x
stT’ah a yaltotl dtfefenri NARm omcel,uel nad s'ti nggoi to akem our lb-βogin notiper kool na(d bevaeh) flaywul n.segart
$279$49