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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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sA rdsediebc ni eht toqnesiu ,estm htsi iutnomat cuorcs wiitnh an niront a( neeg megenst hchwi is ebatrsicndr -&A][RAg;DNNt but nto tle)tsa.drna NRA cpigilsn msyne)ez( bagr ANR nda lop“o i;”t na tnonri si utc otu nad hte seonx on ehtrie eisd fo eth tnnior are jdod,neai ekil t:hsi

2xinxetn—oorneno1— ;&g=t 1nxxo2n—oee

cl,ayylTpi sith nspiilcg scrcou at het yrev esdeg fo eth oinrtn aht(w I detnedo hitw eht ”—“ crcea.)atrh But ni ruo ,acse a tunmaito iwntih eht innort is uanscgi ANR pncsgili nyezme to egiezcnro a new e:tsi eht ecpirls tucs wnhtii teh nnitro (tnadesi of ta eth reyv ge,de sa ti so)u.dhl ,So we get tiemosnhg htat ooslk iekl t:ihs

—2on—nxioxet1rne

hTtas’ a alloytt rfeneditf RANm clee,olum nad 'tsi gigno ot amke our ob-lingβ rtiepno ookl dna( heevb)a yuallfw egsnart.

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drdanielr  I mrmeeebr htat ni hte mpr,eN-RA hte iclgsnip istse fo hte nntiro wreeh eth eimcsploeos csethaat are edsudrnuor yb U-"G-G"A- eikl ,u"gac" so eerh eth lhooosogum NAD to stih ardsnt ouldw be brtdinsecar tino ..".....u.."g...g.a..... dan sthi odulw traeec a 3' eislc tsie oto sono +7
vivarin  if hist is uspesdop ot be Arm-e,NRp hwy ear ehter s'T ni the qeu?csnee 'Im so uendcofs by hsti rfo seom onreas +8
sars  ihsT is teh geen D,()NA ton runtosheegeo ARm.N +
athenathefirst  Teh sgetibg cuel thye sadi ihst is B tmlsaaiseha, ichhw nvee fi oyu ndi'dt nkwo iaghtynn obtau sxnoe adn inrtosn ouy usohdl aevh nnowk hatt b hessaaitlma lsivonev a atuonitm in siicnlgp or erpotrmo stie hmaoatp( eapg )44. I tog iths qtieonus rngwo too :( +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype



 +5  upvote downvote
submitted by monoloco(155)
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This ahs ot od with otninr .glcpsiin eeebRmmr T.GAG sThi tiotumna ucidend an GA lsecro eerhw it swa eodpspus ot ,be so meso of thta nntoir sjut eecmba na xeo.n

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 +4  upvote downvote
submitted by waterloo(126)
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I eteerdpitrn ee"ecnusq ugrdnrsionu fistr two onexs of "eeng - ot nmea hety utsm eb tkilagn botua n.onirts eTreh fo hte senwra ioehccs ntod' heav mhcu to do iwth n.tsionr

  • iesemsns atmonuit wudlo heva to eb in the oenx to sucae chegna ni imnoa i.dca
  • aditpaylonneylo si at teh den fo eht RNmA
  • htiininiob fo leiairoctnp is DNA

thta yam not be ria gh,itt but sleph ronraw .down slAo ikwnong meos -tiseaamasBlh si edu to atnsariv in rmnablao ciigpnls pleh.s AF( 2091 pg )34

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 +1  upvote downvote
submitted by s1khwitit(1)
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asol mrbermee that sshiletBaaam- si edu to ponti nauitmost in clpise itess and eporotmr suenceseq A1F(9 )p014g. If oyu erteac a uottiamn in a lcpsei seit uyo iwll lsryue ssme pu hte trrocec RmAN ndeede to eamk a lanctufoin bB-ngilo niperot. ahTt is who I weanesrd eht iqu.sonet

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