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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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sA dsdbeceir ni teh otuisqen m,tse iths uttiamon ccruso tinihw an intonr (a egne nsmeetg ichwh si etrnacidsrb &t-DR[NNg;A]A utb tno .ltd)rtaneas ARN gcinsilp me)eyn(sz gbar RAN nda lpo“o t”;i na rontin si cut tuo nad het eonxs no trieeh edis of het tninor aer joad,dine ekil ish:t

oxx2—noeenin—ornt1 =;t&g nnxxe—12ooe

ycaill,yTp ihts cilnspig rsucco ta eht vyer gdees fo teh inrnot (htwa I odtndee ihwt eht ”“— rccerta.ah) tBu ni uor es,ac a oiuamttn wtiihn het ntionr is nucgisa NRA iniplgcs nemeyz to ncrieozge a enw e:tsi eht celpsir utsc ihwtni teh itnnro eatni(ds fo ta eth eyrv e,gde as it hu.l)sod S,o we egt ohgesimnt taht soolk keli ihs:t

—oxni—12rnexoetn

s’hatT a ayltotl dieenftrf NARm cllmu,eeo adn 'tis gogin ot aemk uro oiβlbg-n irnepot lkoo na(d vbh)aee flywaul nt.serga

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drdanielr  I rbmmeree taht ni the -NprRmAe, het plcgsiin tisse of the iotnrn rewhe het eoimlcsoeps ttcasahe rae rduouersnd yb --AU"G-G" lkei ,ucag"" os reeh eth hsoluoomog ADN ot siht nasrdt ldwuo be ceirrabtnsd inot .....ga..""g.........u.. adn tihs uwldo atrcee a '3 ecsli itse oot oons +7
vivarin  fi htsi is soupepsd to eb -R,ApemrN wyh rae etehr 'sT in the ncee?sque 'Im os dscnufoe by ihst for mose arneso +8
sars  sThi is teh neeg ),NDA( otn egsheroonuet RmAN. +
athenathefirst  ehT tsegbig cuel hety sida ihts is B eat,hislsama ihcwh eenv fi uoy t'dndi nokw tghniyan batou soenx dan tinrnso uyo uhldso heav knonw ttah b aessmtlaaih iesnolvv a amtuotni ni igcinlsp or rotpmoer siet mhaato(p egpa 44.) I got ihst nsqietou wonrg too (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype



 +5  upvote downvote
submitted by monoloco(155)
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sihT has to do ihtw ortnin .pnisgilc eRembrme ATG.G ihsT auiomntt ciduedn an AG lesrco erhew it saw eupssopd ot b,e os smoe fo atth nntoir sutj aecmbe na .xeon

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 +4  upvote downvote
submitted by waterloo(126)
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I iepredtnetr equcens"e nougnurdsri firts wot nexos of eeg"n - to anem hety umst be lnagtki tboau otrin.ns eTerh fo het arewsn sheocic 'tndo vhae umch ot od with sroinn.t

  • ssnsemei utimanto wodul eavh to eb ni eth oxne to usaec egachn in imnao ad.ci
  • dpntllaiyoynaoe si ta het nde fo het mARN
  • ntboiiinhi of iaoceptilrn si NDA

hatt aym nto eb ria ithtg, ubt hpsel rnoraw on.wd lAso ngwinok soem aBlhs-aseaitm is deu ot rnsitvaa in oalmrban pcsinlig eh.pls AF( 2091 gp )34

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 +1  upvote downvote
submitted by s1khwitit(1)
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aslo mrbereem taht tsaeai-Bhmals is deu ot niopt tutiansmo in escpil tiess dan mreootrp eueqescns 9F1A( 1p.)g40 fI uyo etaerc a ituamtno in a cpsile stie uyo will lusyre ssem pu the eroccrt mNAR deeedn ot emak a cfnuitnlao blog-Bin rtn.peoi htTa si owh I rnwsaeed eth enio.quts

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