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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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sA edercsibd in hte sqtunieo ,etms tsih atonmiut osuccr wthiin an nrtion (a ngee gtemens cwhih si nadsecribrt tAgNAND&-;R[] ubt otn trel)sntd.aa RNA csnpgiil y(ns)emez bgar NRA dna ol“po t”i; na tinonr si ctu out dna het xeson no tiehre dsie fo het tnnior aer ijed,oadn ilek i:sht

xnxo1oe2—nt—eoirnn ;g=&t o1exn—e2oxn

yTa,pclyil hsit gslciinp orcscu ta eht very seegd of eth onritn a(twh I dodteen thiw eht “—” trraehc)ca. tuB in uor a,cse a mttniauo niiwth eth ointnr is nasuicg ANR igiplncs nyemez ot cinrzegoe a wne set:i the selripc scut nihwit hte intron dnstaei( of ta eth eyvr dgee, as it u.sohl)d oS, we etg niehgtmos ttah okols elki tish:

nnn2e1xeirx—oo—t

htsTa’ a ttoyall eiftrednf NRAm lleou,ecm nda st'i ignog to akem oru gnbilβo- pioenrt oolk n(ad eahb)ve wafuyll n.sgaret

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drdanielr  I reememrb tath ni eht ,-ApeNRmr eth spiniclg eisst of the ntinro ehrew hte oelsmpcoise aahscett are deudnousrr yb -AGG-U"-" leki g"ac,u" os ereh het oguoohomsl NDA to shit rsnatd wuldo be ctebnrdisar otni "ug.ga."................ and htsi dwulo rtaeec a '3 selci stei oot snoo +7
vivarin  fi sthi is esosudpp ot be RN,em-prA hyw era terhe 'Ts in eth cneueseq? 'Im os csefodnu by hits rof oems nareso +8
sars  ihsT si hte geen ()ND,A ont hsogtoeeunre RANm. +
athenathefirst  The ibtgegs ulce heyt aids itsh is B shsaltaiaem, chhiw enev fi uoy ddtn'i konw hagniytn uotab onexs nda sinnrto uoy shodul eavh noknw htat b eahmltaiass levvsino a iatmtnou ni ligpnisc ro omotrrep etsi ahp(atom epga 44). I tog stih esuoitqn wrong too (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype



 +5  upvote downvote
submitted by monoloco(155)
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sThi ash ot od wiht otrnni ngicl.ips Rmmereeb TG.AG iThs tountmia nddcuie na GA coselr reewh it aws uesdsppo ot be, os esom of taht notnri tsju eamcbe na x.one

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 +4  upvote downvote
submitted by waterloo(126)
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I teepnrterdi s"nuqeece oundsrgnriu isftr wot sxone of "eneg - to mena htey tsmu eb ilatkgn otbua .stroinn heeTr of the wnesar eohcsic 'todn haev chmu to od wtih rinon.ts

  • ssinsmee mouintta oluwd eavh ot eb in eth eoxn to uceas gechna in ianom aidc.
  • dpnlyoiealnatoy si ta het ned fo teh ARNm
  • oinniitbhi of cpletniroai is DNA

htta may ton eb ira ti,thg btu hleps rornwa d.nwo lsAo ikgwnno emos -tlimsshBaeaa is ude ot savnrtia ni rbnoamla npiilgcs lph.es F(A 9120 pg )34

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 +1  upvote downvote
submitted by s1khwitit(1)
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laos beermmer ttah -eslasahBimat si deu ot tinpo mnstiuota in cpiesl tesis nad trpmreoo ueneqsecs F91A( 0)g4.1p fI uoy tcreae a utmnotai ni a plesic iest ouy wlli suyelr msse up eht orctecr ANmR dneede ot eakm a nnultocfai o-nBbigl nr.opeti That si owh I aerdsnwe eht i.uonsqet

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