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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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As idbcderse in eht esoqutni m,tse hist uttaomni osrucc tiiwnh an niront a( egen metnegs chhwi si drnerctbisa RANN&tAD-g];[ but not adlttn.eas)r NAR spinlcig mzey)e(ns brag RNA and po“ol ;”it na rntion si uct uto nda hte xseon no teihre ised of hte ntoinr rea inoead,dj ilek :hits

eto——onnr2non1xxie t&;=g xe1on2n—xeo

lpyicaylT, shit gnpciils cocrsu at the yvre egdse fo eth rninto w(hat I dedtneo thiw hte ”“— h.a)aetccrr tBu ni our ,seac a tnauotim inwtih eht tnrion si nsciagu ARN cpgilisn ezemyn ot eognecriz a wen t:eis eht psircel stuc inwthi het intnro esdia(tn of ta het yver dgee, sa ti lhodus.) ,oS ew get noihemgst ttah olkso leki :hist

oex1x2n—r—tonine

’sahtT a ttlaloy defenrfit NmAR ocmue,lel and tis' onigg ot amek rou liβb-ogn pietron lkoo a(nd hbeaev) yalwluf ga.sentr

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drdanielr  I eererbmm atth in het Rr-Ap,mNe teh snclpiig ssiet of eht ntonir erewh teh emisooscelp eaahsctt rea urdeusonrd by -A"G--U"G keli "ga,uc" os eehr teh omoogohlus DAN ot sthi ratsnd duolw eb cntserdibra toin ........g......"u.ga..". dan htis dlwuo eecrta a '3 lscei eist oot onos +7
vivarin  if siht is pedpssou ot be reNRAp-,m why are eerth Ts' in hte ?neuscqee mI' os nusdoefc yb htsi fro msoe rsanoe +8
sars  shTi is eht gnee A,)ND( ton seoeornetuhg NR.Am +
athenathefirst  ehT beggtsi cule thye siad shti is B ehimalsa,sat which eenv if oyu 'tndid wokn yntnhaig abtuo eonsx nad srntion oyu udlsoh aehv ownkn htat b lstamahisae vnoelvsi a uotmanit in nlpsciig or opremotr etsi pahomta( aegp 4.4) I ogt this tesiuoqn gornw oto (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype



 +5  upvote downvote
submitted by monoloco(155)
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sThi sha to od itwh onrtin .lsicipng reeRmmeb .TAGG Tihs intuamto deiudcn na AG cesorl herwe it was ppeosuds ot be, os oems fo ttha rinotn ustj embaec na no.ex

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 +4  upvote downvote
submitted by waterloo(126)
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I eiptentderr uecsnee"q usgrnindour ifrst owt xoesn fo en"ge - ot aemn etyh muts eb linkatg utboa osn.rnit Trhee of eht aswrne hsoceic 'dnto heva uhcm to do thiw ninrots.

  • smenessi atinumto wdulo ehva ot be in hte eoxn ot esauc ncaghe in nimao adc.i
  • ainnltpaolyoedy si at teh end fo the mRAN
  • iibtnoiihn fo cprlaeinito is DAN

atth yma otn eb ira ,ihgtt tub phlse wrorna .owdn Aslo nowgikn emos alismtBsaea-h is ude ot aviartns ni mnolraab igniclsp lhe.ps (AF 1290 pg )43

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 +1  upvote downvote
submitted by s1khwitit(1)
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oasl meermebr ahtt amasehlti-aBs si ude ot onitp isotamnut ni pseicl etiss and ooterpmr nqsuceees A1(9F 0)1.g4p fI ouy erceta a numtatoi in a pcleis stie ouy wlil ulsyer msse pu eht tercroc NmRA ddenee to eamk a floncinuta oBbil-ng ieto.npr tTah si owh I aeedwrns the iqose.utn

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