Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.
The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype
Tish sah ot od whti nntroi gs.clpiin reRmebme .GGTA hTis aminoutt duncied na GA escrol eewrh ti aws psdeupso ot eb, so seom fo thta rtnnoi jtus ebmaec na no.ex
I etdtireenpr eq"scunee rgsurunidon srift otw nxoes fo n"eeg - to maen yhte usmt eb klgatin boatu itnrn.os eherT of het wsrean hccoies dton' vhae uchm to do hwti .iortsnn
ahtt mya otn eb air tg,hti ubt eplsh rorawn o.wdn oAsl nowknig moes shiBa-smltaea si deu ot nvarasti in namloarb iplgiscn lpes.h F(A 0129 pg 4)3
oals eerrmbme hatt ai-hBlsmesata is eud to ntiop tmsauotin in ieclsp essit dan rotoremp eqcsunees F1(A9 p).g410 fI uoy create a outinmat in a ieplsc stie yuo ilwl ruyels emss pu eth roetccr ARmN eddeen ot make a uafnilntoc gbion-Bl oteprn.i htaT is how I ewdnsera eht uniqte.os
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$279$49As ebdcesrdi in het tsioequn ,tmse tihs itnoatum srocuc ihwitn an rtinno (a nege smenegt chhwi si etrrabcsdni A&AN]tg;-D[RN tub nto l.ntsedr)ata RAN cpsgiiln mn(e)szey grba ARN dna loop“ i”t; na onrtin si utc tou dan the seoxn on teierh dsie fo het irnnto rae edjnoia,d leki shit:
nnx—2xn1oornet—eoi => 1neoxne—2xo
aipTlyl,yc shit cglnpisi cscoru at het rvye dgese of het tnrino w(hat I odendet whti het —“” .hcrte)rcaa tuB in our ,sace a moatiunt hniwit teh rninot is agnicsu RNA pisnlgci eynzem ot erzgcinoe a wen i:set teh lcipesr ucts intwhi teh onintr id(setna fo ta eht ryev eg,de as it dso).luh ,So we egt tniogsemh atht skloo klei hsti:
xtr—xeneono12—ni
asth’T a lalotyt etfidrfen mARN oceume,ll adn 'tis ggion to aemk oru blo-nβgi eonptri ookl a(nd )ehevab lyalfwu rnst.gae
$279$49