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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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sA csrebddei ni hte ieusonqt mets, itsh tuntaoim csocru ihtwin na nrnoit (a gene tegnsme chihw is scritrndbae D&-]gANAtNR;[ utb ton aratln).dtse NRA piiclngs sey)nmze( rgba NRA adn “polo ;t”i na nrtino si uct uto adn hte xenos no erithe isde of eth rnnoti era ,enjaddio iekl :isth

—i2—oxn1eoxenntron t&;g= —on1n2oeexx

p,Tlaycily hsti lnsciigp ouccrs at the rvey eegsd of the ntrino ahwt( I denetod tihw eth “—” ahrrec.)tca But ni ruo aces, a oumtiant ihtniw hte rntoni is scuaign ARN sncigilp zenyme to iogeezncr a enw tesi: the irspcle ucts tinwhi eht ntonri sdia(net fo at the vrye dg,ee as ti hd.olu)s o,S we get nistoehmg that osklo klie si:ht

—tonri1e—oexn2nx

h’tTas a ytllaot nierftdfe ARmN celuo,eml adn tis' gigon ot meak uor glioβb-n orntpei loko nd(a avb)ehe lwlfyua nsgetr.a

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drdanielr  I ermebmre ttha ni the N,A-preRm eth ingscipl isset of eth roinnt hewer the essilpceomo teachsat aer drdruunose by -UGA"--G" elik c,au""g so erhe eht holsuogmoo ADN ot thsi tdrnas oudwl be nsdarcirebt iont ....a...u.."...g..."..g. dna itsh loudw acrete a '3 sclei esti too onos +7
vivarin  fi htis si dpseuspo ot be rARN,mp-e yhw rae tereh T's in eht ?eeescqnu 'mI os cduesnof by isth rof emso ernaos +8
sars  ihsT is eth geen ,N)(AD tno oeeesronhtug AmN.R +
athenathefirst  eTh geitgsb luce tyeh adsi ihst si B hsmaatesial, chiwh vnee fi oyu 'nidtd knwo ynaghtni bauot nexos nad rionnts you dhousl vhae nwkno that b tsaalehsima vievosln a tmuiaton in pciisnlg ro eotmropr tsei hma(tapo page .)44 I ogt isth itsneqou rgown too (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype



 +5  upvote downvote
submitted by monoloco(155)
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iThs ash ot do tiwh noritn glpicnis. eerbmmRe AT.GG iTsh taumtoni ddeincu na GA srocel whree it saw uppsedos to be, so semo of atth rtinon sjtu acemeb na xo.ne

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 +4  upvote downvote
submitted by waterloo(126)
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I detpeirrnet ueeqscn"e igduurrosnn rsfit tow xneso fo ee"ng - to eamn yeth smut eb aikltgn baout snr.iton Trhee fo the rsnwae shoecci 'otnd have chmu to od hwit sn.nroit

  • semnesis nuottmai lowdu heav ot eb in eht enox to seuca eahgnc ni namio .iacd
  • eodinlpalntayyo is ta teh end of het mARN
  • nitinibiho fo clnprietioa si DAN

tath yam ont eb ari hig,tt ubt hpsle orarnw wn.od lAos nigkonw omes healamBsit-as si ued to rstinaav in obnarmla pnsglici hls.ep A(F 0219 gp )43

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 +1  upvote downvote
submitted by s1khwitit(1)
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slao mebmrere ahtt ae-alssimBtha si ued ot oipnt tuasontim ni liescp tssei dna rooprtem nuceesqse 1F9A( 14g.)0p If uoy eatcre a mtaoiunt in a slcpie stie you lilw luyers sems pu teh crrceto NARm ednede ot kame a anotlucnif logb-Bin ornet.pi tTha si ohw I aswnered eht .sqtueion

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