,oS rof soem n,seroa autmensnirtrtores si egosmihtn Iev' LSAYWA ugesdgtrl i.tw..h ybopabrl aucesbe I astn'w tautgh ti llwe os vrene yallre alrnede it, sjut anedrel ounheg fro awhtvere a.exm I jsut dnufo iths boo ghuroht CBIN dan sti FN!CIATAST sI't fomr 0210 so migth be ,ldo utb it aws ergat. uYo anc rheacs ugthhro teh koob adn indf eth ptces.arh I tyrpet hucm jsut enwt rtohghu all fo het ttmrnortrieenuas cte.rahp Nn.om1.b/w/:9sti.wB/bv.pnhho/g/owkl9tnc7sK0i

My nami ttk waay-eaus:lataGem = rjmao eatoyictrx etr.mtsrneoiurnta owT tspye of ep1: oerc)str ecrobpttm,ioa mtso of hhwic rea csrnytppaei Gi hcwhi slead ot eaeedcrsd DNAM eprectro ivtactiy dna kirs of oicyititioc,txex or opstinstypca Gq sptcoeerr htat elda ot eascneri aN,+ K,+ dna drcdseeea egtmlaaut scsaue ioradpnztoaeil nda esnerdcai +g+M cmtleeapdnsi adn NMAD cerpoter iyticavt dna rski of xyictoo,ceixtit dna )2 rtpooiicno nlacsnhe nndluigci AMND and PanaAAekt/iM hlas,ncen ichhw lal lwalo nopfisiccne ctnoia inuxl,f but olny MAND llsowa a+C+ uxflni (adn lony ni a gvoelta ptnneeedd annerm faert ticffsnieu tialnarzdeioop hsa ldicepasd teh ironbitih g+M+ noi in het nlc)he.an

GBAA nad elgincy = ibtihyiron a.nnttirrmsuretsoe )1 AAAG-B dna AG-ABC = nooritpcoi aneclnsh thta aled to luxfe of ,C-l dan edpseti shti csaingu ziiproneda,tloa teh urnoen still atssy lwebo ingetsr p.aonitlet BGAA-A idibngn iest fro ibsa,butrrate ,soitesdr A,GAB and nxcoiirpto = nidsie peor of ncen.lha AGAAB- ndginib stie of asezbzeneoipind = sdoteui fo rpoe of .nlnehac )2 cGneliy ncenhal is a yver lisamri -Cl xuefl ch.lnena 3) AGBAB- is a moaprotitcbe nlhacen tath isttaaevc iG aleidgn ot rdsceeaed AcPM hwhic ttaeaicsv xffuel +K nslhanec adn nbihtisi +Ca+ xilufn laehncns edglnia to orp.rityonzpaahile

ngceioBi semian = nahioeslacmcet npdemaio rina(icoootdn fo ybod ev,tmemon ,drarew niivooatm,t )meeeicnt,rfron inpreopnerhnei psle,e( ns,selakwuef naitteotn, egnfedi oeihab,rv ephpnienire oelw(ts nrtcooecaitnn ni N),CS lsup ooitenrns e,e(lps wsek,lsnfaeu ,opnesdirse t,xaieny eas)uan adn aiesmhint uol(saar, tiet,nanot elly,rag tiusse aeam,gd nda mya niefencul bdolo bainr l).wof Ouyolb,isv lla of hsti is ni ddtinoia to rneeacdigr semrinoisuntosnra and f,itlgh ,ighftr and gthif pnorsees.

APT nad hetro urenpis = cytirtexoa smao,issirtnn r-ceeelodsa whit throe memsclalo-lelu marreteuntisrtos.n esoidneAn inst' sclciyaslla esodidnerc a nrerremittsotaun uesaebc it 'sint ersol/edesartde in +aC+ dteendnpe neam,rn ubt deeidvr ormf PAT reebfo hagvin an icarttyoex ieontlp.at

tcoyhicAnelle = armjo setatronnriumrte venoildv ni aoesminsnrrsinout iav mcsaunri adn itcnnioic ersptoec.r

tPpedie ouenmenstiatsrrrt = olymcmon eeradlse sa dpritpoepe gearlr rerrscsupo tath rea ceevlda yb psfiicce yenemsz tath wree ni eth same esrrtuiaonenmtrt esivecl opun a.sleere viFe ypets = tbnugi/ar dp,iespet ooiipd tpdiees,p yrutatpii itpdpe,s ociaalyhhptm nielesrga so,eonrhm and osteh otn acfileds.is Epxeamls = erpusrroc ahtt viesg eisr ot atcsnbesu P psu,oppm(hiac oec,nrotxe adn ITG dan dreelaes omfr asllm eiearmtd PNS C esirfb hatt tnasitrm inap nda umepaertrte ooam,irintfn peolwfur ,itnvphoeyes eidbinhit yb oodiip )tesiep,dp rinkineuon A, etudonerppei K, dna predtoiuepne gm,maa dan oioidp etdiepsp inncigldu apntl dlkasailo (ekil ,enp)miorh ntsyhtiec idopoi staii,edrvev nad inrh,sdopen ns,ipydnorh nad nhspeielank. In rgeenal iipodo ipepstde rae setndesaspr ..(ie asanilaeg )hmsan,eimc vonedlvi in lmpxceo ehvrabsio lsaxeu( a,ntrcatito iigrvuees/asisesbmgsv ,o)ervihasb nda lpmiiadcet uh(ohtg ton )nfiitdveei in iicstrpcyha o.ssdirdre

eOrlvla, nrasrturmoetsietn = type ey:tsp cmlaellolesmu- tmsetiatnsrr nda o,pdnrteiupese herew au-llsmeleoslmc rsniamtsrtte era asftre dna emeiadt ipard tycnipsa natsrmisisno .ei(. ganrdnoe SNS /fthfg/rhflggiihtti kquci ,rpesn)eso wrhee as donsreputeeip (nlgao twih coilbiog snamie dan meso lmlsa oluemcel rsisametnttr) rea srwoel and eimaetd ugdar,la pognleord maeinoirtosrnu.ssn

emoS iep:cstru /pcvbneohsopurimin.wrau/e:eotnri/thwfui._kepdvteo/tk_anre_/tmrshpwudstedemla.t, cic1-arR03hswe7/60aapaln2gA1uBwiee8egnab/-dteser-2/dagAupt3t0e3hrTbg/fwli0o9f:451icpr-2er6/f4d6s-biG0eBie1or/g3scn/1-rd-oPetbhpt6.ruasrl4fp8o-msta., dna s3_n8xe-ae0n./39425-.dbsa#libe-c-5e/i/-tf/fhwxlg6ae-giet=gldrw1;1a61atddarwpb0thmgt7ui1o=-p/gase/h2w:rUabl&e.efbf-dn

hguoT quniseto.

allRec ttah nenMeamti m'zseaihel(r dr)gu is a MAND toRecrep ogsinAtnat htat hespl entvrep ixtitotxceocy by kinglBoc C2+a netyr. Tsta'h who I ebermmre ht.is

• )A B-AGAA otepcesrr let lC- in
• )B eicnlGy si used in eth nlapis rocd sa na ibryihinot onstreamrnetriu;t slao eslt l-C in
• C nad E) cpoatobirMet tatemluag eroescrtp rea tnire-opG ucpldeo
• ef,reorhTe the onyl igtnh atth dluoc elt a2C+ ni is NADM ptsceoerr

NDMA recpsteor in isth aesc era nbegi sdue ofr glno rtem itneoitatnpo nhwtii eth brain dan out of lla of erhte eoichsc ylno isth eercprot essu +Ca

You cna rnwaes yb orscsep fo nationelmii. mpteC"iiotev ioir"tscnante meaks yuo nktih ttumiylrsao NT. rssoC out BGAA nad gcel.niy In teh toecxr os mleagtu.at portbiMoctae uolwd enma tehsr'e doesnc srmsneseeg ovidnvel dan eth retcrope oldwu ton tirntasm lcaumci. enecH ADMN.

eusd in logn retm ntiooiptntae glage(,una meomyr), yMa saol yalp a elor ni ngee iaitpcnorrstn ni eornsnu

1) MADN si a tmautlGea oeerpctr s)tbyu pe2 MPAA si a eupsbty fo MDAN ahtt si aiyltnlii cdiatvate by mealtatgu 3e)lrese a MADN etroscper ear ufodn rena AMPA eesortcrp but are otn eiacdtvta yb owl selvel fo tgaaltuem eralsee due ot a gM oni cokbn‘’gil het aenc4) nhl enuqeFrt icAotn aontpteil &—;gt atonitulism fo MAAP &;t—g rszepoidlea opst yinctspa nunore —;t&g aogelvt tenpnddee Mg kcobl of MNDA roecpert dmevoer ) 5 liunfx of Ca hhuogrt DNMA g;t&— esscua vnee mero APMA eprtcerso ot be denistre nito eht merbmnea :(ONTE APMA is prieovness to Ca adn ta)al gu)te6m aeBeusc teehr era ermo roprstcee to dpornse ot t,i het llce is emor resvoepnsi to eamalutgt

all het reoths a neotpcimtevnoi nices yeth vhae iicppfycseiticfic(es g,lsadni) NMDA si het olyn ec(sencvneehntoeli pemvtcieoit )ecpr,eotr ahs a agildn ites nad ca , an nad emec.hn..g mocepvttiei