NBME 22 B lymphocyte (NBME Answers)

need help with your account or subscription? click here to email us (or see the contact page)

search for anything ⋅ score predictor (“predict me!”)

Retired NBME 22 Answers

nbme22/Block 4/Question#34 (reveal difficulty score)
A 17-year-old boy comes to the physician ...
B lymphocyte 🔍 / 📺 / 🌳 / 📖
tags:

+4 upvote downvote
submitted by ∗dr.xx(176)

get full access to all content ⋅ pick a username

Epstein-Barr virus (EBV) is carried by most humans. It can cause several types of cancer. In healthy infected people, EBV persists for life in a "latent" state in B cells.

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004906

get full access to all content ⋅ pick a username

plaguedbyspleen For those wondering like me, a heterophile antibody test is referring to the monospot test here. Reactive heterophile antibodies in a patient with a compatible syndrome are diagnostic of EBV infection. (uptodate) +2

+2 upvote downvote
submitted by ∗almondbreeze(110)

get full access to all content ⋅ pick a username

uw: EBV commonly infects B cells, stimulating them to enter the cell cycle and proliferate continuously ("transformation or "immortalization"). this is accomplished when EBV-encoded activate proliferative and anti-apoptotic signaling pathways w/i the infected B cell. ... the immortalized B cells maintain the ability to secrete Ig and B-cell activation products (eg. CD23), with very few of them releasing virus particles at any one time.

get full access to all content ⋅ pick a username

Must-See Comments from nbme22

sacredazn on Unrearranged immunoglobulin gene
seagull on Decreased binding of RNA polymerase
seagull on Anticholinergic
mcl on Area labeled ‘D’
liverdietrying on Release of stored thyroid hormone from a ...
kernicterusthefrog on Displacement
keycompany on Negative nitrogen balance
joha961 on Displacement
imgdoc on Area labeled ‘C’ (Abducens nucleus, right)
alwaysanonymous on 25 mL/cm H2O
drdoom on 1 in 600
seagull on Glutamine
yotsubato on Phase variation
bubbles on Acute retroviral infection