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NBME 22 Answers

nbme22/Block 4/Question#23 (20.1 difficulty score)
A 57-year-old woman comes to the office ...
Autoimmune downregulation of Ca2+ channels of the presynaptic terminalπŸ”
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 +7 
submitted by welpdedelp(225),
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sbryant6  Lambert-Eaton is typically associated with Small Cell Lung Cancer. Since there was no mentino of that, I was thrown off. Such is the difference between UWorld and NBME I guess. +1  
makinallkindzofgainz  I'm laughing about Myasthenia "gracias" lmao +16  



 +0 
submitted by trichotillomaniac(110),
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ndeibitsoa from iaasgtn eth epipnreyatvs +C2a chnlsnae ta hte tMNm-sJo oomcnmly esne ni isatepnt thwi alsml llce lnug arccne




 +0 
submitted by trichotillomaniac(110),
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ioibtndase frmo taainsg teh panvrtpeiyes a+2C hcnansle at eth tMsmoJ-N mynloocm snee in tetainsp twhi small llce lung nrecca




 +0 
submitted by tekkenman101(0),

This question is pretty bad because down regulation of calcium channels in PREsynaptic neurons would result in LESS ACh release onto the motor-end plate, which would cause down signaling and impaired excitation-extraction coupling of muscle. This is because that mechanism needs depolarization and release of calcium to work.

I guess you just can't overthink it lol.