NBME 22 Answers ↦
useful figure http://users.atw.hu/blp6/BLP6/HTML/common/M9780323045827-036-f002.jpg
Why wouldn't this be similar to a Type 2 RTA where urinary pH <5.5?
I can't remember exactly what the question was asking off the top of my head, I think it was asking about relative to normal? But I think you're right in that the alpha intercalated cells (AIC) can still dump H+ into the urine and acidify it to an extent. And, like in RTA2, I don't know that the action of the AIC would be able to overcome the bicarb and acidify the urine enough for it to be the usual pH, so the urine should still be more alkaline compared to baseline. Kinda sucks, pH less than 5.5 should technically be acidic but it's alkaline for pee.
JK, normal urine pH is around 4-8, but I guess they consider closer to 5.5 on the more alkaline side...? I guess I would go more off that the alpha intercalated cells can't completely compensate for the amount of bicarb in the pee due to the CA inhibitor, not so much the actual pH.
Anhydrase inhibitors also affect the anhydrase inhibitors that are used in the AIC in order to excrete the H+.
Here is a link:**http://pedclerk.bsd.uchicago.edu/sites/pedclerk.uchicago.edu/files/uploads/distal_0.png**
ohhhhhhhhhhhhhhhhhhhhhhh my god duh yes thank you <3
the question is asking what would happen to the URINARY ph, bicarb, and volume. dont worry, i misread the question too -_-
Also misread the question, thought about the lab volumes of the BLOOD smh
yooooo me too!!! this is the second NBME i did this on they purposely don't write urine on the arrow categories to mess u up i swear!!! AHHHHHH
missed this question for the same reason .. still pissed