NBME 22 Diarrhea (NBME Answers)

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Retired NBME 22 Answers

nbme22/Block 3/Question#3 (reveal difficulty score)
An obese 45-year-old woman with type 2 ...
Diarrhea 🔍 / 📺 / 🌳 / 📖
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+6 upvote downvote
submitted by aaaaaaa(6)

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orlistat is used for weight loss (its not a statin as some people thought in the comments here). its in FA 2019 pg 294, m/c side effects are GI including diarrhea

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imnotarobotbut Thanks! It's actually page 394 +2

tiredofstudying FA 2020: Page 400 +

+3 upvote downvote
submitted by ∗groovygrinch(39)

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Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine.

Don't break things down in the intestines----> osmotic diarrhea

Apparently people use it to lose weight. Who knew. Not me

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drzed I believe it is the only FDA approved weight loss drug and has actually shown efficacy in diabetic patients. +

-8 upvote downvote
submitted by ∗bubbles(79)

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Sorry if I'm being dense...why does this woman have diarrhea due to statins, diet, and exercise? I didn't really understand what they were asking for here to be honest.

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.ooo. I believe they were asking what the most common effect of statins, which is GI upset (including diarrhea). Rarely you can have hepatotoxicity and myopathy but neither of these are a side effect in the answer choices. Hopefully this helps! +3

niboonsh Theyre asking about the most common side effect of Orlistat - which is really fatty diarrhea +3

asharm10 Orlistat is not a statin drug, it basically inhibits pancreatic lipase so that you absorb less fatm drug is used for weight loss. So when you are not absorbing fat you are inviting diarrhea. +2

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