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NBME 22 Answers

nbme22/Block 3/Question#3 (23.4 difficulty score)
An obese 45-year-old woman with type 2 ...
Diarrhea🔍
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submitted by aaaaaaa(5),
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arlttios is sdue rof ewight lsos (sti tno a asntti sa meos opeepl uhothgt ni eth temsonmc h)ere. tis ni FA 2190 gp 9,24 c/m desi efesftc rea GI idilnngcu dehairra

imnotarobotbut  Thanks! It's actually page 394 +1  
tiredofstudying  FA 2020: Page 400 +  



Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine.

Don't break things down in the intestines----> osmotic diarrhea

Apparently people use it to lose weight. Who knew. Not me

drzed  I believe it is the only FDA approved weight loss drug and has actually shown efficacy in diabetic patients. +  



 -7  upvote downvote
submitted by bubbles(63),
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orSyr fi Im' igenb ..enwdys.eh does thsi namow veah ahraeird due to nsa,itst ,tedi nda icx?sreee I dn'dit yrlela tnddrsuean hatw htey rewe sgknia rfo eehr to be n.tseho

.ooo.   I believe they were asking what the most common effect of statins, which is GI upset (including diarrhea). Rarely you can have hepatotoxicity and myopathy but neither of these are a side effect in the answer choices. Hopefully this helps! +1  
niboonsh  Theyre asking about the most common side effect of Orlistat - which is really fatty diarrhea +2  
asharm10  Orlistat is not a statin drug, it basically inhibits pancreatic lipase so that you absorb less fatm drug is used for weight loss. So when you are not absorbing fat you are inviting diarrhea. +2