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NBME 22 Answers

nbme22/Block 2/Question#42 (21.2 difficulty score)
A 75-year-old woman has taken 12 ...
Plasma renin activityπŸ”

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 +7  upvote downvote
submitted by privwill(20),
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etpS by et:Sp

  1. sIDASN okclb rnsotnialgdpas chhiw nollamyr atlied eth fntfeear rairloeet
  2. sitonConirct = edesedcar dbolo owfl ot llgroeusmu (ecdaseedr ;FGR reedsdcea RFP)
  3. derDcsaee dlobo lwfo edsla ot ivcnaitato of RASA ytesms
  4. naAvtcioit fo RSAA edasl to nescedira nnrei

Wyh tno het ehotr osn:e

.A FRG wlil be deeerascd due to rsictonincot of eht faertfen
B. nleRa oodlb fowl iwll eb dseaedcre deu to iortnvtcosnoacis fo teh farntfee
D p;&ma E. ocPtinurod dklcobe by ISDAN so utn'lowd enev be oarndu

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I nkhti the eseacinr in pmaals iennr cttayivi itwh sAINSD sha ot od wthi iniiotnhbi fo fentfree yrrate toiildna by ptnasordgnsila (2)P,EG nsiec hsat't ahtw NIDSAs od yb tiignihnib OCX. hsiT eceadedrs ralne dloob flwo lsaed ot ASAR ittiancova ot cernoevs wtrea nad amttlyieul nrnei sresca.ein

htballer55  Afferent artery dilation* +5  
link981  There is decreased afferent renal artery dilation (less blood flow) leads to increased renin release from the juxtaglomerular cells (located near the afferent artery) to try to increase blood flow. I got it wrong but after reviewing saw my idiotic mistake. +1  

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submitted by lilamk(10),
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I am so s!fnoudec ehT lnoy goicl I ldcou emoc pu w is that IsASDN aerecsde tdaoilin fo aerneftf areerolit so ihts eomr oecrncidstt eeirotlra si ndreteiretp as deresdcea oblod owlf nda nReni nrace?ssei My eiuss w tihs is atht hewn I lgogoe ti and rhseca WU rfo isth nnire tfafce nohitng smcoe up ylon eaitrcl I lcuod ifdn utyaacll stadcorntci ti dan says nirne owudl EDESCARE mfor SDNsAI legnaid to eth kymereaaplih ew esostiemm ese ...

ynA ghtosuht udwlo be !ehlfupl saTkhn geuesisn.

generic_login  I used that reasoning to pick C, but in looking it up now it seems like you are right ... There appear to be a bunch of mistakes on this test, and it’s not giving me a lot of confidence for the real thing. +  
mee48  I think it is because NSAIDs inhibit the local prostaglandin (PGE2) in afferent arteriole β€”-> less AA dilation β€”-> stimulation renin release. I think my reasoning came from sketchy pharm nsaid video but I can’t 100% remember +  
keycompany  NSAIDs constrict the afferent arteriole. ​ A. GFR would decrease due to decreased renal blood flow. B. Renal Blood flow would decrease. C. Renin would increase due to renal hypoperfusion. D & E. PGE2 and TXA would decrease (by MOA of NSAIDs). +4  
fallot4logy  UW says that Nsaids is one o +  
fallot4logy  UW says that Nsaids is one of the 5 drug categories that is able to cause hyperkalemia.Specificly ,Nsaids lower PG andrenin secretion .PGE2 stimulates JG cells to secrete renin...(how can i delete my previous unfinished message,lol?) +1