From Faid 2019 new figure: IGF-1 mainly functions as an anabolic hormone on muscles and bones (pretty much like insulin-> decreases serum glucose). GH acts separately by promoting insulin resistance (increasing serum glucose). Therefore, IGF-1 is not the answer. If GH was among the answers it would have got really confusing.
I think a lot of you missed the point. The answer is Cortisol because it helps maintain blood pressure even in the setting where he is malnourished.
Looked this up. Starvation causes GH resistance. Never heard of this, unfortunately fell into the trap of thinking increased GH would increase IGF-1. Punished for overthinking.
Anyone know why IGF-1 wouldn't be increased as well? GHRH is stimulated in hypoglycemic states.
I just used common sense to rune out the answers here. Firstly, knowing that cortisol is increased during times of stress (starvation; like this stem). Insulin causes hypoglycaemia so the body wouldn't produce more in a stressful state (expect glycogen to be higher). IGF-1 acts like GH and these states of growth require energy which this man clearly doesn't have. There wasn't enough to support testosterone and T3 changes so those were ruled out pretty quick.
submitted by โhayayah(1212)
He's not eating enough.
One of cortisol's functions is to increase gluconeogenesis, lipolysis, and proteolysis.