nI rdeor for a durg ot be erceald by het iyn,edk ti mtus srfit eb erlfetdi ni hte ge.lroilmu usgrD hwti a gihh VD hvae mreo fo the dgru ni hte isstue atht era ont abellavai ot edfilrte yb eth edink.y ugDsr hitw hihg rinteop bgidnni 'twno be fitreeld eih.rte oS oyu want a udgr ihwt olw Vd nad olw dgbinin fi uyo tnaw ti dcrleae iva het neksdyi dna eni.ur

Kap si Hp ta whcih yan urgd is at sit 50% odieniz tts.ea

oNw we ear kal urnie .ei inc Hp. hnwe ppKHgta;& it wlil have owt dfif paht orf icicda gdru ;p&ma csiba g.udr

iiAccd rgud ilwl nci sti iamilnentio cni( ziieodn ,)ofmr ibsca rudg will be mroe bs.srd aoobe we edne to wokn hte rudg si bsica d/ic.aic

wNo if u akl iunre sti miiitnelaon ci.n os ti ahev to eb ai.icdc ro u nac wnok tis a dosi lats of rdug ithw SCN erpproyt e.i otsm ilke anbPloerhitab aWek( di)ac

so fi apK fo rdug si -t6-a- Hp 7 ew lwli astrt negtinailim

but fi pKa is 0 ew ende ot aiser Hp fo nurei at 11 to ttars igmaetialnnti. htat niopt epvr gdur pK(=)a6 woldu be oallytt otu of messty.

httas hwy A si the tgirh asn aKp( = 6)

If uyo tawn ot lecra a ,dgur ti is aybbropl ebst taht it not be ubodn to epnstoir o(s tath it setg t)redlefi dna ti sha a wol mvluoe of nuriidisobtt (os it si'tn ni eth edpe, ahrd ot echar essi.)stu

grhialt etls do htis. soem fo eth tecomsmn eerw aleyrl lwle pilda,nxee veeowrh im oingg ot rty natoreh o.true ltse dlae itwh aKp cnsie the erhot omtsemcn lixedaaenp Vd wlle ehg.nuo sdouk f.sle/aesflllo

rifst tgihn si yuo veha ot edteiemnr fi its na daic ro b.sae 09% of teh imte ist ngoig to be a aewk a,cdi we mlsiep notd ueftalmor mhuc tiemidoncsa sa sseab in erln.age olsa ist uiodsm aslt nad CSN so uoy knwo it hsa ot eb eoaatihbl.rbpn spte 1() owl Kpa esman icda (.)74- you smut ownk .hsti (2) you msut wnok taht lal cdisa atstr fof lutaenr adn etnh eslo an oni g-;t&- obnecimg aregh.cd dna lla saebs rastt off hraegdc adn etnh soel an oin ot ebcemo ulrtaen ih(ts is hyw we dnto sue iabcs gsdru ceuebsa itsh rualnet chareg ash a hihg vd adn ssptdoei in ssuetis = dab ni eydrell). yuo tnaw acrhedg cb thsta hwta is pidcrlhioyh aak pee ti u.ot )(3 exnt esu wath i sujjt asid and lapyp ti to hist r:hact

+2 = %99

1+ = %09

1- = %10

2- = 1%

het tisfr bmerun errsntepes hte fefeciednr weenebt pH nad Kap Kap( si iegnv yb the uesiontq )wys,ala pH is hawt uyo dncageh ehnw uoy dalalezkin teh .nuire so orf iths quieonts it luowd e:b paKHp- = hgih siacb luaev t;(g7&) msniu pak ( kawe daic ).-74

now het nscedo eenacgpter epersrnets eth cgeetaeprn of iisocdedast tponr.o os rof an ,iacd hyet lwil ecboem dh,gearc thsi neams atht fi het cdfeenerfi bentwee the hp and paK si vero +1 enht 90% fo the icad liwl og fmro aurtenl ot hacerg.d fi teh hp si 2+ rgaetre nhat pKA hnet 99% of teh cida ilwl evha lots sit nptoro nad ceomeb dgerach

selt erzsiumma hist: wree dtlo ist a awke iacd = kaa apK etenebw 4-.7 we tnaw to egt ot teka eth keaw daci mrfo sit utnealr rofm into a dcgahre mrfo to etg ird of i.t so we leilanzkaa the nuier, usaceeb sseba aer gerihh pH ouy llwi teg a reom + nbumre thus the wake dcia liwl go omfr unltaer to crhdgea adn be teexrec.d

I saw wnderiong if ti was ot lolwa for alpatir NCS enettnraiop nsiec het grdu is soedulpsyp uepdsosp ot aveh NCS ecetff

rfo eakw pHk=aasi cpd + ogl AAH(/()-) kaa esnherdno blsschaaeh qe iioufant uoy oslev ,isth ly'oul gte ttah Hp - kpa = ()aA(olgH)n/dA - enth ignaa oyu wlil teg 01 ot owper hp - akp = HA.A-/ eR[fre ot lnki in mw]on omtsnce ironcdegsin ttah teh hp fo uor dybo si 37. h wmee,sngito acn selov rof akp 10 nda akp 6 nisgu sith fulTa thorm.a si ofr pka 6 adn dybo ph ,3.7 it liwl eb 01 ot eht prwoe of 1.,3 lowdu neam that HA/A otiar si a ivpotsie brmne,u plinigym ttha -A &;gt .HA aehwres for wnhe akp si ,10 hte /AH-A iortan is 10 to oewrp fo 27-., gnnmeia atht &g.A;t-HA

dnA as dlayrea oedntnmie ni the aobev ontmsem,c ew nede na cinoic f,mro ot tmnaiiele eht r,gud it lduow eb ferrrpeed if the pka si 6 as in atth ae,cs A)iico(-n olwud eb ni erom octeton.raninc

so htwa if iths wsa dneiesvr ewrhe het dugr ni sqoneiut aws a bsae dan atht ireun swa eiiad.iifdc nowk het paK wuodl eend ot be t;7g& utb wtha tuaob hte pH

coentm[m vemdo to mtecbmon]su