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ankirin
Why wouldn't it be T3? Thyroid hormones also โblood sugar and break down lipids
+1
waterloo
@ankirin his symptoms aren't really specific for T3. They don't mention tremors, exopthalmos etc. I think just in physiologic terms, you can bet cortisol is more increased. It's not a great question though imo
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rockodude
can someone comment on why his appetite is down, per first aid 2019, page 329, cortisol increases appetite. thank you
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lifeisruff
his daughter isnt there to bring him groceries
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medstudent22
T3 levels decrease in states of starvation in an attempt to preserve energy. T3 is incredibly metabolically potent - even more so than T4. By decreasing peripheral conversion of T4 to T3 (ie decreasing T3 levels), you are decreasing metabolic activity in "unnecessary tissues", decreasing ATP use, and increasing overall energy availability for necessary tissues (brain). On a side note, rT3 levels may increase but this is not metabolically active and will not be measured as an elevation of T3.
Dr. Ryan had a great explanation of this in one of his thyroid videos.
https://pubmed.ncbi.nlm.nih.gov/12055988/
+1
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dbg
Sure, charcot. Just wished on her to get a couple of charcots (the triad, your aneuryms, marie tooth, etc).
+2
noorahsaahir
Charcot_bouchard and dbg best comments .... ๐คฃ๐คฃ๐คฃ๐คฃ๐คฃ
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feanor
I hope she gets anal ulcers and ascaris both at the same time. Imagine the worms laying their eggs on top of em while she sleeps with the guilt.
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pakimd
according to pathoma, cortisol is the hormone neccessary for life. in a condition like the one presented in the Q-stem the most important hormone will be cortisol.
+3
pontiacfever
Also Cortisol is generally a stress hormone. Starved body is generally understress--Cortisol
+1
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bgreen27
Ok, from what I understand, starvation may induce GH resistance, but starvation STILL stimulates its production. The question asked which hormone would be increased in concentration, so this doesn't really explain why IGF1 is wrong. One possible explanation I found is that AGING inhibits GH secretion, which is not the case for cortisol.
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drdoom
It makes evolutionary sense that if your body is in starvation mode it is not going to be releasing an ANABOLIC signal (Growth Hormone). If you're starving, you'll need to stop โputting on massโ and continue to catabolize fatty acids, glycogen and whatever other stores your body has left. (It will have to way away at itself simply to generate enough ATP for vital functions [fuel for heart, brain, kidney].)
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bgreen27
I totally get where youre coming from, but the fact is that starvation DOES increase release of GH (but apparently also increases GH resistance). So my qualm was with the question stem asking about which one increases in concentration, and GH and cortisol both increase during starvation. Have you found something different?
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nala_ula
Honestly, it's something that has confused me for a while. Why is it that GH secretion is stimulated by hypoglycemia? I mean, it's literally called growth hormone (for growth!), and hypoglycemia, which is basically a "starvation" state, will stimulate this hormone?
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temmy
IGF-1 is regulated by insulin. so it will be decreased because insulin levels are also low.
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nwinkelmann
I found this and it also explains to a more genetic/cellular level. Essentially, it says that starvation induces some factors that cause GH resistance and IGF1 suppression.
+1
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submitted by โhayayah(1212)
He's not eating enough.
One of cortisol's functions is to increase gluconeogenesis, lipolysis, and proteolysis.