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Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

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 +7  upvote downvote
submitted by vshummy(184)
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I ntkih orme ae,lnryegl roetpni gildnfo enpahsp ta eth RRE dan hte tesm says the pornite ’edosnt lodf rp.plorye acyiSipl,cfel hte mtso ncoomm CF tanioutm si a ofddselmi rotniep nda teh itrenop is nadteeir ni eht RRE nad ton srdtrpaoten ot eht llce membrane - AF 2019 gp 6.0

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uroosisyed5  iWhch askem sseen fi we ithnk tbuoa hte hsoahytpp of evleedta Cl- dna aN ilaltrua.lnlceyr Boht of eesth soin go pu esndii teh lelsc due ot eth nnteotrie fo the ifedmodsl psreoint in the .ERR +
lilyo  I taculaly garseied hwti siht raoesinng. The oyhaoiyslgthpop in FRTC is nto deu ot uutcoanmcila of dsdmeiolf .roptisen tI is ude to aesrdnebaceted/s PAT atged erbantnmrmeas ldoriCeh h.cnneal ngAdrccio to U,dwrol hte edcoimds preotin is ddcteeet yb the dlnoamsiEcp Ritl.emuuc The arlaonbm oiteprn is eatdegtr for utscodrniet yb hte srmeaotoep and veren shceear hte ellc efsc.ura heTer si ON ttioenrne fo lomddefis in,roetp ethre si traoiganedd fo msoefddli ptnoier adn ererfteho eacesbn fo erdcohli eslchann on hte nea.bmemr hTis is hawt lesad to adieipmr lvarmoe fo alst orfm eth sewat as llew sa ecesdader alNC in mc.suu I dtno htikn het esarwn oulhsd eb RE. nCa aoeynn eltl me if I ma gimsnis sghnmetio eher thta emaks het snewra RE as deopsop to ptaycmol?s sBecaeu het wya I see if is olmidefsd oisntrep og rfmo the RE tino the msatylcpo ot rhaec teh roetemaosp dan then be sdrtee.ctdu doUrwl ssonuteiq DI ear 580, 820, 514,1 adn 19.39 +19
drdoom  olil@y Teh RTCF si a esarrmtbnname teon.pri eLki all ensp,rtoi ist iaslntnarot inbesg in het tyo;olcs ttah sd,ai TFCR aconntis na utmn-ersNi naisl“g nueeqs”,ce cwihh snmea as it is bigen snartletad, ti (nda teh rbosiome nkiamg !ti) ilwl eb ptorrntesad to eht solpmadcEni tmuooftieouetcl.R!^n As it esgt ,rsnadaltte ist ricohpybdho tsimof will egmre,e hicwh besmde the TRCF prnetoi inwhit hte pholsdhppiio brileya fo het RE ef!tils Ttha enams eth oenrtip wlli renve gania be onudf in“ hte oslt”cyo saucebe ti gets trdaedhe rhohtgu eht yiblare (hhiwc i,s ni f,tca owh lal mbeaemtsrannr nroepsti bceemo etbraarsmmnne tespnior at eth clel afsucre -- tehy aveh to be amed otin ersmnrabatnem nptoeisr in het RE .stf)!ir +11
drdoom  li@oly noticnue(d) ,So ye,s uatiylml,te tehse lidofesdm irpteson lilw be tderiecd atordw a aerpmoesot ofr agargndeoced/ltirnyi,c utb ttha lwli phpnea sa a lltite eevcsli r(o ;”omo“ls)ipe eht fldeimdos r,inopte ni tshi asce, si ton rwslbeteuol-a sin,(ec by i,niifondte it hsa iyordochpbh oimfts cwhih get a“edtdehr ”uhhrgto a ralyieb to acteer the mtearemabnnrs )entp,tra wihhc anmes yuo ’wnto dinf it in eht ol.ctoys +6
drdoom  eoot!tfno^ : heT mtmoevne of eiacvt* reioosbsm romf the cosyotl ot the amplosncidE tcRuieuml si hwy ew lcal hatt reaa of RE rhu“og pmndlicEosa clteumRui Er;R()” no tceonler o,orcpicsmy that cetoins saw skbeelpecd whti tiellt tod;s rte,la we h(um)ans eodsidcvre taht ehset ostd erwe oibmos!res +1
drdoom  * yB ev“ctai msioo,sbe”r I ustj eanm mosborsie in eht oespscr of rtcnngvioe AmNR to pn!etoir Wt(ah ew acll n”“toaritnlas ); +1
wrongcareer69  owH mnya agdomnd wsya aer yeth ggoni to sett us no .CF mI' so ovre !sith +2
furqanka  olsa ni A,F uernd plaah 1 pnn,atystiir tis sysa ddsoilMe'f geen croupdt tnpiero trgaseegag in ctephlllroaeau ".RE ihmgt be het emas npecc.ot +9
joanmanuel26  Aniocgdcr to nK;lapa llA neriopts atht ear yhseisendzt in teh RE smut dofl otrreccyl in erdro ot eb oraetsrnpdt to eht ligog turapasa nda thne to ethir ainfl sentt.dosnaii fI the nomtiatu saecu a ldefsdmoi ietorn,p eht lrsuet lilw eb eht sosl fo eth rtpnoei ctnfniou ,nad in msoe cas,es talamcciuonu fo eht notpire ni the R.E +1
drdoom  @lyoli kinTngih btaou iths r.emo ouY wlil ont nifd eth omilfd(sd)e optenir in het olcsyot. hTe seoifdmdl eioprtn yam eb dneiis a nperaodmts—oea a pesoaermot yam vile in het otbt—yoslcu het deisofmdl roptien leitfs iwll reven aaerpp ni teh loysct.o hTe todcsurp of its ntdodiaager tighm nictsnt(otue nimoa iadcs ro laslm pidtse)pe tbu if you dha an oadyinbt fro teh midelsfod trpenoi adn eadsk it her“We is hte eisdfdmol ,?pn”irtoe eht boatnyid uwold w:esarn “tsoM fo htaw I ocudl fidn apeapsr to eb in teh .ERr” +
yesa  Cehck otu het naxienlc c,cyle lulsuay rteonpis ahtt ear dame in eht RRE adn idfmeosld teg geagtd dna 'e'lrdfeod dna nhte ndsenac aangi for rreppo ao.idngld.f.n fi yeth leryal an'ct eb fder,edlo yreth'e rdgddaee then dan ete!hr So hte ynol alepc dfdemlsoi TRFC oludc cuaeaulctm if imldfeods ...sER.i..R. L(kni ot cnlaixen :lecyc hEgma/0mYHgu&Un3h.Q=cD2Xmox;85r;poli;5e=/oQev1wYt?=AseQpwVas:Cy50i.4s6Qsmaa3O1pIp1=lmLc=eo0&&j9t=m;TAeQ8t:hw8=iwCdgeeILc;A;qfib1b=Xw8&jjsugHc98_hsppahD+g7cOerBvRDxKrsoIaa4bmAaKMp9ElKnmsg7oh;7Mgm4a&AU2iaUrpakF2rH#5rZht2a=ZarB7PmIUVh/U+&Wbmwi&s) +
amy  20F02A 47: " tAsbne or sdynocliuantf RSP lg(sain nicoierognt aitpl)rec seslrut in tuuiacnmloac fo tenpior in eth st"loyoc +
drdoom  m@y,a th’tas a odgo iotnp tub ti essmaus the renitpo si itserewoh mraln,o .e.i, ton fomsedlid ro mb”anlra“o ni oems rtoeh wya +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

+/- drdoom(1206)

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 +4  upvote downvote
submitted by seagull(1933)
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I aehv an susie whti sthi eontqusi chiwh laso ocfscitln ihtw UdWl.or nI roerd to be gddaeder yb epeomsostor eth ledmdsoif neroipt wduol need ot eb terespn in teh otlocys orf but.oniiuan tI it cmdaacuuetl in het RER ehtn hwo sdeo it teg ggdtea? eotyl,sHn os cdltcnieo.f..

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sajaqua1  oS ariodliyrn a lidsedmof iponert osed eoungdr nibuqitnuiitoa nda ersy.loisotp It is betnleao ahtt FTCR dfiinomgsl ntsde'o veen wlola ti peesca the ER, so ti stlmaceucau ni the ER +9


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 +4  upvote downvote
submitted by drdoom(1206)
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ehT RFCT tpneoir is a ammsnnarrbtee .tprinoe kLie lla tns,oripe tis trlsonianat iegbsn in hte cstol;oy taht ,dais TFRC ainostnc an enmrsNt-ui ins“lag qcsu”e,ene wcihh aemsn as ti si ignbe ,nrsaedtlat ti da(n the rmieboos making )!ti llwi be nptdreroats ot eth ilapmdEscon luuime.tRc^oo!ttfeno

sA it tges ttsdalrna,e sit bdhicopyohr otmisf liwl reee,gm chwhi bemeds het CTRF teniopr iihtwn het dpplohhiopsi lbareiy fo teh RE e!tifsl hTat emasn het ptoiner wlil eevnr gnaai eb funod n“i the oloscty” aesucbe it tges rteahded otrhguh eht byealri ihwc(h ,si in t,fac who lla saebmmrnrntea toienprs ocemeb neamenmrrbast rinspeto at hte elcl uscarfe -- yeht vaeh to eb amed tino mbsnanrretmea stporine in het ER !.t)fsir

,oS s,ye lailu,tmtye eshet fildmedso tpsnieor wlli be ericdted roawdt a emeraspoot orf ggaraddenne,ytrci/oicl ubt thta will nheppa sa a litlet vliesce ro( “elom”so)i;p het eldsmifdo niort,pe in ihts ,saec is tno -lsutrweobael ise(c,n yb io,dniefnit ti ahs drocphoyihb otfims cihhw teg arte“hded uhotrhg” a yarebil to raecte het anaremerbmtns )tnrape,t cwhih nsmea uoy nwto’ ndfi it ni het yolcso.t


\ ntotfo!oe \ hTe itnhhcgi of tcaevi* sobsoimer to teh pnEoamcidls eRumcltiu is why we llca hatt aare fo ER hrg“uo csnodimplEa tucilmeRu ”R)Er;( on onertelc oycriocmp,s atht eitcosn swa bleksecpde ihwt teillt os;dt a,eltr ew uh)(ansm dscrieeovd atht heets dost rwee iomsrs!ebo

\ * \ yB vtia“ec mes”o,boirs I tujs amne eosisromb ni het ocpesrs fo trnveignco RNmA ot pinrtoe! a(tWh ew alcl arl”osa“intnt );

For a eratg tltiel urymsma of the apionsdclmE emtuRucil d(an yamn etohr tecopscn in luclroema gy!ol),ibo see isth form erbstA’l erlalMcou gloBoiy fo the leCl:
//o/i2.t8kpgK1vNb.ocb4ow.h2:nw2/n/swl0t6#h.Am4nisB

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drdoom  ^ 'Im tjsu -traisgnet in oen oenmtmc twha I owtre in emliuplt umobtcssnme a:ebov /mo4tm7e/#asn1r3c9//e.nxs/e9:ahn3etpbw29bmsm +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

+/- drdoom(1206)

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submitted by therealslimshady(42)
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When itperson nibeg made in teh ER mdl,oisf thye ectlaucuma in eht RE, ihwhc hnte sirgretg tmeh ot be stpi uot iton het ctoyslo nda bmceeo adgddree yb rssaotoe.emp suTh, eht luiatacmoucn fo eht dsefdomli nrptoei in het ER si drqrueie rfo hetm to ileauytmtl eb gtdega yb qniibiuut and be eegdaddr ni apmotsreeo.s

vnEe if uyo reuag atth yhte illw eb gumitccuaanl ni het tsyoolc eeucsab sesmpoerato rea in the slcot,oy eth nqetoisu is aknsgi hewer are teh teiornps ticuaualgmcn, tno ibnge agddeder. oS ythe a'ctn ulaccamteu in rpom,staseeo euescba heyt ear srdtdyeeo in .hmet

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drdoom  eicn acthc with hte in“agc”lmuucat marerk! qq, wneh uoy asy “esrgitgr hemt to eb stip tou iotn hte oyltocs”, od uoy haev a rosuec orf ?ttah ot'nd erclal ianergnl atth wenheyar ly.smef th!x +1
therealslimshady  I actn' mrerbmee wrhee I eard tish but it ksctu twhi me, I thnki ti saw a llce bio ookb +


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submitted by mutteringly(33)
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hsTi si ofrm somasb: tuMedta TFRC nege F5(8Δ0 oattni)mu → foiesddml peornit → fdeceviet itronpe si riedntea in eth ougrh mcdanpioels tmuuirlec R)rE( fro daiaedtgrno → TatePdg-A ichdlreo nhclnae is ebsatn no het cell efsaurc of ahilelepti llcse tgoutuhorh teh boyd ,.e(.g etalistnin dan rarteoiyspr atihelpei, weats nd,glas onericex r,ecnspaa eixcroen dasngl fo pvtroieeucdr onasgr)

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submitted by unknown001(9)
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URATL MSIPEL.

rt1ehe. rae naym rastvina fo yctsic ifoisbsr os itsh qusnteio si otn ubtoa ypp.shtayh fo FC

tio2p.n fo siqonute : ehwer osde opetirn lngfiod ourcc ? neraw)s RRE

  1. NI SIHT PEYT FO FC , if penotri ionst dfledo elryrpop ni RRE wlli it og otu ro liwl it tcualmcaue ? ens)arw it liwl lauamutecc ni R.RE

TPI : IF OYU EKPE HAINCESRGER ON NIVASTAR OF ,FC UOY ARE NO A ATHP TO LDSNESE MDOO

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submitted by blah_blah(1)
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efullh pabewnyaG/whyio=cguQ.?hsp;atulmomnNc/.ch/isu&_be:o=jHv3lftswtIXaawpgntoyeB

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submitted by welpdedelp(270)
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_9L/gg0gsg33w81nkm_.i/o8mnHl9p09MT1en1=n:t/Mb525Fo/s02as5y3.d4Pn_sp5/3171oe2iphtivh/rcC2i/s_2e..42229?e_

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