For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I aehv an susie whti sthi eontqusi chiwh laso ocfscitln ihtw UdWl.or nI roerd to be gddaeder yb epeomsostor eth ledmdsoif neroipt wduol need ot eb terespn in teh otlocys orf but.oniiuan tI it cmdaacuuetl in het RER ehtn hwo sdeo it teg ggdtea? eotyl,sHn os cdltcnieo.f..
ehT RFCT tpneoir is a ammsnnarrbtee .tprinoe kLie lla tns,oripe tis trlsonianat iegbsn in hte cstol;oy taht ,dais TFRC ainostnc an enmrsNt-ui ins“lag qcsu”e,ene wcihh aemsn as ti si ignbe ,nrsaedtlat ti da(n the rmieboos making )!ti llwi be nptdreroats ot eth ilapmdEscon luuime.tRc^oo!ttfeno
sA it tges ttsdalrna,e sit bdhicopyohr otmisf liwl reee,gm chwhi bemeds het CTRF teniopr iihtwn het dpplohhiopsi lbareiy fo teh RE e!tifsl hTat emasn het ptoiner wlil eevnr gnaai eb funod n“i the oloscty” aesucbe it tges rteahded otrhguh eht byealri ihwc(h ,si in t,fac who lla saebmmrnrntea toienprs ocemeb neamenmrrbast rinspeto at hte elcl uscarfe -- yeht vaeh to eb amed tino mbsnanrretmea stporine in het ER !.t)fsir
,oS s,ye lailu,tmtye eshet fildmedso tpsnieor wlli be ericdted roawdt a emeraspoot orf ggaraddenne,ytrci/oicl ubt thta will nheppa sa a litlet vliesce ro( “elom”so)i;p het eldsmifdo niort,pe in ihts ,saec is tno -lsutrweobael ise(c,n yb io,dniefnit ti ahs drocphoyihb otfims cihhw teg arte“hded uhotrhg” a yarebil to raecte het anaremerbmtns )tnrape,t cwhih nsmea uoy nwto’ ndfi it ni het yolcso.t
\ ntotfo!oe \ hTe itnhhcgi of tcaevi* sobsoimer to teh pnEoamcidls eRumcltiu is why we llca hatt aare fo ER hrg“uo csnodimplEa tucilmeRu ”R)Er;( on onertelc oycriocmp,s atht eitcosn swa bleksecpde ihwt teillt os;dt a,eltr ew uh)(ansm dscrieeovd atht heets dost rwee iomsrs!ebo
\ * \ yB vtia“ec mes”o,boirs I tujs amne eosisromb ni het ocpesrs fo trnveignco RNmA ot pinrtoe! a(tWh ew alcl arl”osa“intnt );
For a eratg tltiel urymsma of the apionsdclmE emtuRucil d(an yamn etohr tecopscn in luclroema gy!ol),ibo see isth form erbstA’l erlalMcou gloBoiy fo the leCl:
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A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
When itperson nibeg made in teh ER mdl,oisf thye ectlaucuma in eht RE, ihwhc hnte sirgretg tmeh ot be stpi uot iton het ctoyslo nda bmceeo adgddree yb rssaotoe.emp suTh, eht luiatacmoucn fo eht dsefdomli nrptoei in het ER si drqrueie rfo hetm to ileauytmtl eb gtdega yb qniibiuut and be eegdaddr ni apmotsreeo.s
vnEe if uyo reuag atth yhte illw eb gumitccuaanl ni het tsyoolc eeucsab sesmpoerato rea in the slcot,oy eth nqetoisu is aknsgi hewer are teh teiornps ticuaualgmcn, tno ibnge agddeder. oS ythe a'ctn ulaccamteu in rpom,staseeo euescba heyt ear srdtdyeeo in .hmet
hsTi si ofrm somasb: tuMedta TFRC nege F5(8Δ0 oattni)mu → foiesddml peornit → fdeceviet itronpe si riedntea in eth ougrh mcdanpioels tmuuirlec R)rE( fro daiaedtgrno → TatePdg-A ichdlreo nhclnae is ebsatn no het cell efsaurc of ahilelepti llcse tgoutuhorh teh boyd ,.e(.g etalistnin dan rarteoiyspr atihelpei, weats nd,glas onericex r,ecnspaa eixcroen dasngl fo pvtroieeucdr onasgr)
URATL MSIPEL.
rt1ehe. rae naym rastvina fo yctsic ifoisbsr os itsh qusnteio si otn ubtoa ypp.shtayh fo FC
tio2p.n fo siqonute : ehwer osde opetirn lngfiod ourcc ? neraw)s RRE
TPI : IF OYU EKPE HAINCESRGER ON NIVASTAR OF ,FC UOY ARE NO A ATHP TO LDSNESE MDOO
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$279$49I ntkih orme ae,lnryegl roetpni gildnfo enpahsp ta eth RRE dan hte tesm says the pornite ’edosnt lodf rp.plorye acyiSipl,cfel hte mtso ncoomm CF tanioutm si a ofddselmi rotniep nda teh itrenop is nadteeir ni eht RRE nad ton srdtrpaoten ot eht llce membrane - AF 2019 gp 6.0
$279$49