For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I hvae na eisus tihw shti tusoqeni wchhi saol nficlocts ithw rWo.Uld nI erodr to eb adegderd yb smsoperoteo eht olsdmefid oenrpti doluw deen ot be treneps ni hte coytlos for ubatuioinn. tI ti luaetdmucac ni eth RER hetn hwo esdo ti etg ?aeggtd Holtsy,en os .ten.dilccf.o
eTh TFCR ipretno si a rnarbeeantmsm eni.otrp kLei all rpeso,tin tis tonlrtinsaa gesibn ni het s;ocoytl htat a,sid RTCF sitoncna na srN-muntie nas“lig sunqeece,” hhwci seamn as it is nigbe nla,settrad it dan( the siormeob kgnmai t!i) lilw eb naptrtreosd to het aEdnmspciol utul^mRice.tfneo!oto
As ti esgt ldta,nstera ist bophohydrci fmisto iwll gr,eeme hhcwi bdmsee eht RTCF inrtepo tihniw teh hsppihooipdl yrlaebi fo the RE t!slfei hTat nasem hte epntoir will enrve agani be onufd i“n the cytosl”o aceebus ti tseg aeredhdt thrghou het yrebali (wihhc i,s ni tca,f hwo all srnrbaemtemna oiretnsp ceebmo reeaatrbmsnnm srntioep at eht ecll rfsueca -- they aehv to eb edma toni mbmtenanraers ipeosrnt in the ER istr!.)f
,oS yes, lyl,imetaut steeh dlmdosefi niorptes liwl be eticredd wtdaro a pomreostae fro ed,elgico/agdnrtcyarin but atht ilwl hpnepa as a lettli icveles (ro me)is;“lpo”o eth esldodfim nrop,tei ni stih cas,e is not tbosel-lrwuae s(,enic by oefdniin,ti it hsa ocioprbhydh tomifs hchwi get ahdter“de ”gorhthu a brialey to arecet the msernrebntmaa tp,tae)rn hciwh msnea ouy not’w difn ti in hte tsc.loyo
\ foteo!tno \ heT nhcighit of itvcea* bsomsroie ot het lpisodEmcan uiRmletuc si hyw ew lacl tath area fo ER hgur“o podcaEmslni mclRuueit Er)”(;R on ereclnot oocyc,smirp that ostecin saw pkcslbeeed iwth tltlie sod;t elrta, we ush)ma(n eocredidsv ttha ehets dtos eerw ri!bsoemso
\ * \ By vtce“ai i”boroe,ssm I usjt nmae obermoiss in eth sprcose fo nroietgvcn mNRA ot tenr!opi hta(W ew lcla ti“osan”trnla );
rFo a agtre ltelit yrmsmua of eht Eoidnpslcma cRulmeitu adn( ymna other optncesc ni rlaueomlc ,olg!)iybo ese itsh ofmr bAlte’rs eoarllcMu ooigyBl fo hte llCe:
w1o/l/gs2.6k/i.hb/:2phwNBin4t#ncnK8o..mA/w0vs2ob4t
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
ehnW itospner eigbn aemd in het RE s,dolfmi tehy aacmuuctle in eth ,ER wihch neth eggrrtsi etmh to eb stpi uto iton eth sltyooc and eobcme gerdddae by .pmosaetoers ,suTh eht ulocimcaatun of the emsfodidl eroipnt in hte ER si iurqeder fro mteh to lityutlmea be eatggd yb qunibiuit adn be regdaedd ni teos.eaomrps
nveE fi ouy egaru ahtt yhte wlil eb icaumtcluagn in teh tocosly aecseub oasetopmser are in eth cylso,to eth onieqtsu si ngsiak wehre rae het nprieost lcgatmuuanic, otn begni eeagddrd. So tyeh a'nct mcatucleua ni ro,oesetamsp ubaeces they era edrysdoet ni .mteh
hsTi si form aosbsm: dautMte CTFR gnee Δ0F(58 anmtoi)tu → ofldemdis rptieon → citeevdfe nrtepio si eitadern in eht huorg slpoanmeidc lcertimuu E()Rr ofr gdarotnaedi → e-TgPadtA droichle anhlecn si asnebt no the clle efacusr of hatieelpli llsce ohugrhtuto het ybod (.g,.e lnstienait nda ariryrsepto iehil,etap waest ansd,lg recneoxi a,aprencs ieconxre lndags of orevduecptir )rsogna
ULRTA IMSEPL.
eh.1ert era mnya rniavsta fo syctci sbforisi os stih etsuinqo is tno ubato ypsathph.y fo FC
.o2ntip fo oeunstiq : rehew seod rontepi oldifgn crocu ? a)sernw RER
TIP : IF YUO EPKE GRECHAERSNI NO IVRAATNS FO FC, YOU ERA ON A ATPH OT SSDENEL MDOO
le fpuhl_aHlemhhob3&.n;nsluc/etospwBtwn:poostcygXbivu?Ghmyw=Qwug/aa=Ni/.tcjfIeaay
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$279$49I hkint more e,lyrgalen eitponr godnlif npaepsh ta het RRE nad het stme syas eth ntioepr nosetd’ ldof el.oprypr fialc,epSlicy teh somt momocn CF namuttoi si a ldismdofe tpoinre adn eth eitpnro is nadteeir in the RER dan otn eprasottrnd to eth cell nmbaerme - FA 0192 gp 06.
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