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Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

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 +7  upvote downvote
submitted by vshummy(184)
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I hkint more e,lyrgalen eitponr godnlif npaepsh ta het RRE nad het stme syas eth ntioepr nosetd’ ldof el.oprypr fialc,epSlicy teh somt momocn CF namuttoi si a ldismdofe tpoinre adn eth eitpnro is nadteeir in the RER dan otn eprasottrnd to eth cell nmbaerme - FA 0192 gp 06.

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uroosisyed5  chhWi ekmsa esnes if we khtin utoba teh potsphhay of evdtlaee Cl- and Na n.yrutlrclaliela Both of heets nios go pu diinse eht lcsle eud ot eht eitnernto fo the lfdmodeis rpnsieot in het .RER +
lilyo  I lluyaatc eidasger twih htis ngeoirns.a ehT oyopliptghsyhao ni FRTC is ton due ot oaaulnmuictc fo elfiddosm nspi.etro tI is ude ot dree/csdntaseeba PAT aedtg maraetrnsbnem dlCeihor n.lhaecn dcgoncirA ot dolwU,r hte oimscedd rinptoe is tedtdece yb teh iaEnmolscpd temRuculi. The anmrabol npritoe is tdergate for ncidsteotru yb eth roteesopam nda rnvee rceeash eth elcl c.euafrs eerhT si NO noirneett fo odldisefm pnt,eior ehrte is oaeainrgddt fo defldisom ernpito dna oterehefr naebsce of ceodilrh nalenhsc on het me.ermban shTi si thaw lades to mrpedaii aloermv fo alst morf eth aswet as llew sa arceddees ClNa in cumu.s I dotn nhtki eht wersna ldsuho eb .RE anC nnaoey tell em fi I am sgismin mtgisonhe ehre ahtt ksmea eht nreswa ER sa espdpoo ot mtyospa?cl seueBca the yaw I see fi is fmieddlos tersponi go omfr the ER nito eht cmpyltaos to ecahr hte temasoepor adn hnet be dd.ctureset Uwldor nqoeustsi DI aer ,058 8,02 41,51 dan 3.199 +19
drdoom  @ilyol The TCFR si a nnbrmeatrsema pitn.roe ikeL lal sinrotpe, ist lstaoinntar ensgbi in eth slotco;y ttha ds,ai RCTF sctionna an s-ntrimuNe lagn“si ,ee”nusqec wihch manes sa it si gibne artaesld,tn it n(da eht rbiosmoe inakmg t)!i lliw eb rpdntestroa ot hte lmnpaodiscE .u^Rcnfelioetutomt!o As ti steg la,enatdtrs sti cdobpyhrhoi oftism wlil ee,mger hhiwc debsem eht FRTC otpneri ihintw teh hppolsdpohii libryea fo het ER !slftie ahTt amnes the tonepir lilw evner aigan be nofud ni“ teh to”ycsol beesauc ti gtse adtedreh ugohrht het rlaiyeb hhi(wc ,is in a,tcf woh all amearsnmerbtn netsirop meebco nbertemarsman enprstio ta the clel efucars -- they aveh ot be emad otni reebsmnmtnara eosrntip ni the ER tr.!fs)i +11
drdoom  @illoy deniuno(t)c S,o ey,s ,etalitmluy hstee mdeidofsl ptsenoir lilw be ecddriet towdra a seomperato rof a/ro,acencyneigritdgdl tub htta lilw appehn sa a little eieclvs o(r o)oi;”sl“pme eth dfsidmleo otrnpei, in sith easc, is otn leurslbteo-wa ,ni(ces by t,nofnideii it ash bhdhrpiocyo sitfmo whcih gte rthaee“dd or”tughh a ryibael to tceare het nmretbnemsaar )enraptt, cwhih mnaes yuo o’tnw ifdn ti in the .ylsctoo +6
drdoom  ^!ttneooof : heT vmmeento fo itc*vae smooirsbe omrf teh olyocst ot eht cnaElimspod tuRclmeiu si yhw we allc taht eraa fo ER oru“gh dEomcilsapn mtiulcRue ”R(;)rE on ltrecone ,cricpoomys tath snciote asw clebksedep iwht ittlel stdo; tra,el we anuh()ms ceridsvedo that heset tsod weer meso!ibsor +1
drdoom  * yB “eatvci esbor,sm”oi I stuj neam emorsobsi ni eth sesorpc of toigrvncen ARmN to prnoe!it Wt(ah ew clla l“tnrti”anoas ;) +1
wrongcareer69  Hwo nmay aoddngm ways aer yeth gnigo ot estt su on .FC 'Im so vore h!sit +2
furqanka  saol ni ,FA dernu ahalp 1 styt,nairnip sit yssa ddf'oiMsel eegn rdopuct rotepni sragaggeet ni cuehotellalrpa E.R" tgimh eb eht emas onc.pcet +9
joanmanuel26  ornigAcdc to pKal;na llA opetsnri taht rae tesydnzihes in het RE smtu olfd ytlrrceoc in edorr ot eb dtaoprrtsne to hte oglig upraaats dan hetn ot rhiet anifl eittdaonnss.i fI eht ontmiatu suace a eldmidosf rie,tnpo the rlsteu lilw eb the sosl fo eht eonptir uncifton n,da in moes asc,es ocalnamuucti fo teh onterpi ni the ER. +1
drdoom  @lyoil inhkniTg atubo iths e.rom Yuo iwll ont fdni hte eolfdms(id) reintop ni eht oty.clos hTe esldmofdi itnoerp yma eb inesid a o—tanspearemdo a esmpraooet yam ievl ni the bc—soutltyo het sdioflemd rionpet ltisfe lwil ernve rappae ni the cy.sotlo heT stpuocrd of ist draegointda mhitg tcteunto(isn miona ascdi ro llams )eipetspd btu fi uyo adh na itnboday rfo het doslimfed niotpre dan aksde ti eh“reW si eht sddmfoeli n?p,”rtoei the nbtidaoy ulowd wsr:nea so“Mt fo thwa I dlouc infd rappase to eb in the .E”rR +
yesa  ckehC uto the xilnenca yc,lec yulalus eospitnr tath aer adme ni het RER dan fslddoeim tge eggtad dna o'defe'lrd nad ehnt acnesnd angai ofr porpre .na.nlif.odgd if thye yallre atc'n be l,deeofrd yere'ht dgadedre nhte adn hee!rt oS teh noly caelp eoidfmlsd RCFT cuold lmeuccuaat if imlseodfd REi..R..s... L(nik ot naclneix cleyc: t=d/I1aQsv+Ha1iIrr5eb#vX8UKcXAm+rPpwQe9oKr5jUpbA4btxj28a03riM;T17QFHeUscam8EZYah?&/mquL=5aUUhp=7mWyV2or9i;Q7xYe;i=g7peOwf0Z=Bwp_CAwmgV4;C1=;Amew;46ngLwE.shpe8cDiila2aA:&ahaapDmstm:ahbg=suOc0c&kIDom2sa&ge9=jso&/&8.mos=phrRQ&KM;lBH5gtoglsnImh3h) +
amy  22A0F0 47: " nteAsb ro inysaclduontf SRP isnag(l iotgcornnie elita)rcp trlsuse ni mtluanaouicc of pnortie ni het ctlo"yos +
drdoom  mya@, tath’s a dgoo iptno btu ti ssumsea eht tieporn si seothirew r,lonam ie,.. not smefidodl or arnbo”mal“ ni smeo heort wya +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

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 +4  upvote downvote
submitted by seagull(1933)
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I hvae na eisus tihw shti tusoqeni wchhi saol nficlocts ithw rWo.Uld nI erodr to eb adegderd yb smsoperoteo eht olsdmefid oenrpti doluw deen ot be treneps ni hte coytlos for ubatuioinn. tI ti luaetdmucac ni eth RER hetn hwo esdo ti etg ?aeggtd Holtsy,en os .ten.dilccf.o

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sajaqua1  So rrldioynai a feldsmido niopter sdoe unoedrg nitniobuqautii dna ytsieo.rpslo tI si aoetelbn hatt FTRC niidfolgsm etdson' veen alwlo ti eapcse the E,R so ti luctecuaams in teh RE +9


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 +4  upvote downvote
submitted by drdoom(1206)
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eTh TFCR ipretno si a rnarbeeantmsm eni.otrp kLei all rpeso,tin tis tonlrtinsaa gesibn ni het s;ocoytl htat a,sid RTCF sitoncna na srN-muntie nas“lig sunqeece,” hhwci seamn as it is nigbe nla,settrad it dan( the siormeob kgnmai t!i) lilw eb naptrtreosd to het aEdnmspciol utul^mRice.tfneo!oto

As ti esgt ldta,nstera ist bophohydrci fmisto iwll gr,eeme hhcwi bdmsee eht RTCF inrtepo tihniw teh hsppihooipdl yrlaebi fo the RE t!slfei hTat nasem hte epntoir will enrve agani be onufd i“n the cytosl”o aceebus ti tseg aeredhdt thrghou het yrebali (wihhc i,s ni tca,f hwo all srnrbaemtemna oiretnsp ceebmo reeaatrbmsnnm srntioep at eht ecll rfsueca -- they aehv to eb edma toni mbmtenanraers ipeosrnt in the ER istr!.)f

,oS yes, lyl,imetaut steeh dlmdosefi niorptes liwl be eticredd wtdaro a pomreostae fro ed,elgico/agdnrtcyarin but atht ilwl hpnepa as a lettli icveles (ro me)is;“lpo”o eth esldodfim nrop,tei ni stih cas,e is not tbosel-lrwuae s(,enic by oefdniin,ti it hsa ocioprbhydh tomifs hchwi get ahdter“de ”gorhthu a brialey to arecet the msernrebntmaa tp,tae)rn hciwh msnea ouy not’w difn ti in hte tsc.loyo


\ foteo!tno \ heT nhcighit of itvcea* bsomsroie ot het lpisodEmcan uiRmletuc si hyw ew lacl tath area fo ER hgur“o podcaEmslni mclRuueit Er)”(;R on ereclnot oocyc,smirp that ostecin saw pkcslbeeed iwth tltlie sod;t elrta, we ush)ma(n eocredidsv ttha ehets dtos eerw ri!bsoemso

\ * \ By vtce“ai i”boroe,ssm I usjt nmae obermoiss in eth sprcose fo nroietgvcn mNRA ot tenr!opi hta(W ew lcla ti“osan”trnla );

rFo a agtre ltelit yrmsmua of eht Eoidnpslcma cRulmeitu adn( ymna other optncesc ni rlaueomlc ,olg!)iybo ese itsh ofmr bAlte’rs eoarllcMu ooigyBl fo hte llCe:
w1o/l/gs2.6k/i.hb/:2phwNBin4t#ncnK8o..mA/w0vs2ob4t

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drdoom  ^ 'Im jtsu tsaigtern- in oen nmcteom hawt I rowet ni plimelut msntcsombeu oe:vab 92bembnea:s49sw/9mmcrxetn#e//1m37p/.sn/ha3ot +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

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submitted by therealslimshady(42)
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ehnW itospner eigbn aemd in het RE s,dolfmi tehy aacmuuctle in eth ,ER wihch neth eggrrtsi etmh to eb stpi uto iton eth sltyooc and eobcme gerdddae by .pmosaetoers ,suTh eht ulocimcaatun of the emsfodidl eroipnt in hte ER si iurqeder fro mteh to lityutlmea be eatggd yb qunibiuit adn be regdaedd ni teos.eaomrps

nveE fi ouy egaru ahtt yhte wlil eb icaumtcluagn in teh tocosly aecseub oasetopmser are in eth cylso,to eth onieqtsu si ngsiak wehre rae het nprieost lcgatmuuanic, otn begni eeagddrd. So tyeh a'nct mcatucleua ni ro,oesetamsp ubaeces they era edrysdoet ni .mteh

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drdoom  enci ccath thwi eht taimcla“unu”cg ermkar! q,q ewhn uyo yas erirts“gg hmet ot eb psti uot into teh c,tlooy”s od oyu heva a ocrsue fro that? t'ond lelrca engariln that rayeenhw elfmy.s !hxt +1
therealslimshady  I cnta' emreebrm erweh I reda isht btu ti sutck ihwt m,e I inkth it was a elcl ibo kobo +


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submitted by mutteringly(33)
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hsTi si form aosbsm: dautMte CTFR gnee Δ0F(58 anmtoi)tu → ofldemdis rptieon → citeevdfe nrtepio si eitadern in eht huorg slpoanmeidc lcertimuu E()Rr ofr gdarotnaedi → e-TgPadtA droichle anhlecn si asnebt no the clle efacusr of hatieelpli llsce ohugrhtuto het ybod (.g,.e lnstienait nda ariryrsepto iehil,etap waest ansd,lg recneoxi a,aprencs ieconxre lndags of orevduecptir )rsogna

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submitted by unknown001(9)
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ULRTA IMSEPL.

eh.1ert era mnya rniavsta fo syctci sbforisi os stih etsuinqo is tno ubato ypsathph.y fo FC

.o2ntip fo oeunstiq : rehew seod rontepi oldifgn crocu ? a)sernw RER

  1. IN HTIS ETYP FO FC , if rteniop tiosn dfdeol rpprloey in ERR lliw it og uot or ilwl it cuumcatale ? we)nrsa ti illw uluamtceca ni .RER

TIP : IF YUO EPKE GRECHAERSNI NO IVRAATNS FO FC, YOU ERA ON A ATPH OT SSDENEL MDOO

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submitted by blah_blah(1)
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le fpuhl_aHlemhhob3&.n;nsluc/etospwBtwn:poostcygXbivu?Ghmyw=Qwug/aa=Ni/.tcjfIeaay

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submitted by welpdedelp(270)
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/g28Mho/1?1H3./oso94ns/1n4_e.3pn29e1L05lg/=c255swnp:n_2b9skmy2.r9pi2/hei_7_8gdT03_i23stM2C1v/50geFP.imat

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