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Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

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submitted by vshummy(184)
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I khtin mero lnrge,leya oirpnte ignofld hppesan at eth ERR dna eth smet ysas eht noriept odt’ens lodf rlyprp.eo aic,yfllSiepc the smto moncmo CF ntaioutm si a ofieddmsl riotnpe dan het peiotnr si deeinrat ni het RER nad ton oanptdrrtse to teh llec abnemrem - FA 9210 gp 06.

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uroosisyed5  ciWhh makes esnse fi ew tknih taobu teh hotahpspy of eeleavdt l-C and Na rr.tnalluaciylel thoB of hseet sion og pu iesind het elcls ude ot eht erionnett fo eht sildemfdo trniospe ni eth ERR. +
lilyo  I llutaayc geedrasi ihwt sith o.rniaensg hTe aspihhpgyooytlo in RTFC is otn deu ot aimuucaotcln fo liodefdsm i.orntpse tI si ude to dsceasabeer/tend APT eatgd rebsnmtenrmaa rodieClh .ahcnlen cgirAnocd ot ,dlUrwo teh dcmdoesi eoprnti si eteddcet by teh alomEdipcsn uilec.mtuR The mrlbaano oitenpr is tegreadt rfo utdosnirtce yb teh raotmeeosp nda evner ahcsere het lecl efcau.rs Trehe is NO rienteton fo ddsilfemo noept,ri there is rddigneaoat fo odlfiesmd eioptrn nad orhtefree ancsbee fo dehiclor helncsna on the eramm.neb hiTs si hwta sadle ot aimriped vmroela fo tsla mrfo teh aswet sa wlle sa edeacserd CaNl ni sc.umu I ntdo khint teh arswne dhlsou eb .RE anC nneayo lelt me fi I am mgnisis esgointhm ereh atth mksea eth aenwsr RE sa ooedpps ot oym?lsatpc eaBusce the ayw I ese fi si ddlsimeof postreni go rfom eth ER niot het cymaotlsp to arehc hte meoasrtoep dna ethn be c.dertuetds wdloUr toiesnsuq DI era 50,8 2,80 ,1154 adn 9.913 +19
drdoom  yolli@ heT RTFC si a srmmetrnbenaa .piotner eikL lal ist,oerpn its irtnantsloa ebsnig in teh tloo;cys atth das,i TRCF oitnsanc an semitunrN- gsn“ail us,qen”cee ihcwh nmeas sa it is ngibe trdatnasel, it dn(a hte oorsmbie nmkgai !t)i ilwl eb setrpatrndo to the dlpEsonimac teuRoei!o^m.ctuoftln As ti sgte eadlrt,atns sti bopohihycrd stfomi iwll rm,eeeg hhcwi meedbs het TFRC tnierpo inihwt eht pdiospiophlh aliryeb of eht ER sitfel! taTh snaem eht ontrpie ilwl enver ngaia be ufond n“i het s”ootcly cuesabe it setg teeadrdh rghothu eht bayriel (hihwc is, ni ,tfac how lla nemsnraatbmer ptnsioer cbemoe tenrarsmnabem petsinor ta the ecll aecusrf -- yteh aevh to be dmea toin tbnnasmeremar pitoners in eht ER )sir.ft! +11
drdoom  loily@ tn(ocui)ned ,oS ,sey emil,ytatul heste lisdfoedm rieopnts lwil be ederidtc rdtawo a aeomsorpet rfo decctyagan,glodniei/rr ubt ttah lliw epnpah as a leittl lievesc (ro ”oeiol;)spm“ eth oiflmdesd pnieor,t in hits ,scea is nto sowbla-eurlet (iesnc, by oidift,nnei ti hsa oypbihordch fmisot cwhhi egt “treaedhd rh”uhtgo a ryilbea ot cetear the enaermsbmrtna eprn)tt,a hhiwc masne you wt’no ndfi ti ni eth .olcysot +6
drdoom  ooen!fot^t : ehT mtnevemo fo iav*cte romesoibs mfro eht sooytcl to eht scionEamdpl eRtiulmcu si hwy we alcl atth arae fo RE rg“uho ndaEcpsliom iltRumceu E(”rR); on erltcnoe omrcs,yiopc atth tcsieno aws seecbdlpek wtih tlteil sod;t al,ter ew (masu)nh doevdsrcei atth ehtes sodt eewr emr!boisso +1
drdoom  * By iave“tc ebi,osm”sor I tujs emna mrbsesooi in eht eocrssp of ctvrnnioeg mNRA ot per!ntoi at(hW ew call ansitrlt“na”o ;) +1
wrongcareer69  owH ynam gdmodna wsay era heyt igngo to ttes us on F.C I'm os reov h!sit +2
furqanka  sola ni A,F endru apalh 1 nsyn,ttpiiar its ssya de'ioldMfs egne tropucd neotrpi agesaegtrg ni lapholelcauert ER." ghtim eb eht aems en.ccotp +9
joanmanuel26  incdoAgrc to ;anplaK All rtnoiesp ttha are eyhdsnezits in eth RE mtus dlof toyreclrc in reord ot be apdoetrntsr to het gilog sapaartu and tnhe to ethri lfani ntnodi.aietss If teh oainttmu acesu a sdleifmdo eprt,nio eth eltrsu will be teh slos of eht oetirnp uiotfnnc dn,a ni seom aecss, taaomlcuuicn fo eht rpetoni in eth E.R +1
drdoom  loyli@ hTgnkiin abotu ihst oer.m uoY illw not indf eth d(fisol)med nptoeri ni teh soytcol. hTe mldedsofi tneprio yam be indsie a aa—nedtsroompe a aeepotosrm aym evil in the s—toulbcyto eht fdoeslmdi otniper itfels lilw envre aapper in hte o.tlscyo heT ordctspu of tis agdeodtrain htmig tnottc(euins nimoa caisd or slmla tes)idepp tbu if uoy dah na atobiynd for eht dodsfelim trpoine nad deska ti rh“eWe is teh smdoifdle ren?p,oti” teh tonyidba doulw ne:rsaw ostM“ fo tawh I ldcuo dinf rappase to eb in het Er”R. +
yesa  cehCk uto teh lnxnaeci c,eylc yulasul itnoserp atth ear emad in the RRE dna doifledsm etg gedatg nad eo'df'lred dna ethn cdnsnae gnaai ofr eporpr n.dilagnfod.. if htye llarey tc'an be fre,oldde ye'rteh gaedredd hetn nad !heetr oS hte lyon eacpl dsmoeidfl FTRC ldouc mlcuauctea fi elodsidmf i...E..s.RR. Lki(n to necnlixa c:lecy Y=rCbghroZgh&3t1opt/&Hd+;Rc8fcmQ7OU7AT/rQ=:&x7hrVee0ao.Lc;agpWaOwgm8p5&2;aH8bcIAEXsQi;KpDVi?ue&=r5Cm;Di5ahan1mZbtcojP&tIvBmavXw;wmsmsp#j6s48aksr9=noK=axIDsYA0;m101hoi_+mlwUmyaspQe=UUg&sqUmB2aa2=IQ9K/AA8r5e9wib==ElFiMHge2L3:hhuMwjageps4e.74lhp) +
amy  220FA0 47: " Anebst or ytsodnlfnaciu PSR naigs(l rinegnoocit ctelp)ari suletrs ni uucciltamaon fo neprtoi in teh "oyslcto +
drdoom  ,yma@ htsat’ a good onitp ubt it usmaess het tpienro si rteihsewo ,nmoalr .e.,i nto edidmfosl or aba”ron“ml ni smoe threo yaw +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

+/- drdoom(1206)

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 +4  upvote downvote
submitted by seagull(1933)
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I heva na essui tihw shti sneqtiuo ichhw salo nfcoltcsi iwht Wl.rUdo nI edorr ot eb dedargde by ooeerstospm eth dimoeflsd eorntip loduw dene to eb esrntep in het styoolc fro iuatn.obiun It ti mtaldeccuua in the ERR hent who deos ti egt ?gagdte nHeots,yl so etnlc.iof.d.c

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sajaqua1  So radolinriy a ifdsedmol toripne does ogdnreu nntiqauiiibout dna srio.otlsyep It is aoltebne ttha FTCR ofslimding ostden' nvee llawo ti epscea the R,E so ti ceuuacmslat ni hte RE +9


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 +4  upvote downvote
submitted by drdoom(1206)
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hTe FRTC eoptinr si a remetnambrsan r.oinpte ikLe lal netro,sip sti oaslatnnrti siebng ni eht c;yostlo ttah dsi,a TFRC isantcno na nu-Nmisret ig“lnsa ”seueecnq, hicwh smnea sa it is bengi ntlt,daarse it n(ad hte riosembo nakgim )!it illw eb psertdaornt to hte limcapsdEno emuutcli.R^tenfoo!ot

sA ti tegs slearntta,d tsi hrodcoiypbh mtosif lwil ,meeegr cwhhi seemdb hte FTCR itonerp tnihiw hte dlosopiipphh yiblera fo het ER tilf!es atTh nemas teh tonrpie iwll ervne gaain eb dfuno “in hte socyo”lt ubaesce ti tesg eredtahd togrhuh het aiylebr ih(hcw si, in aft,c hwo lla mnrseaberamnt eritspno bmceoe maemenbnratrs eirtpnos at hte lecl rasufce -- yeth haev ot eb dmea tnio rebmarnnamets eotpnsri in eth RE !rf)sit.

So, ey,s telymali,ut hetse ddfmelois tpsnoeri ilwl eb edeitdcr rodwat a maptoeeors fro dn/cnlraggriyaoceed,ti utb ahtt lliw eahnpp sa a tetlli eeclvis o(r pm“ol;oeis”) hte fsmdleoid teon,rip in stih aec,s si ton euab-relslotw s(eic,n yb iit,oneindf it sha oroiydpbchh fsotmi hcwhi etg ehtrde“ad ”uhrgtoh a lrybiae ot trecae eht eatmenbsnrram rp)tt,aen cihwh seanm yuo twn’o idfn ti ni teh .scotoly


\ tnooftoe! \ ehT ihtnchgi fo at*veic bmrissooe ot eht ipaEsncolmd ueRmtilcu is yhw ew clla ahtt eara of ER ug“roh moniapEcsld utuiRclem r”(;)ER on lneocetr ,omcopriscy ttha nitcoes saw edbeseclpk whit tltiel ;dsto ater,l we sahu)m(n eocdirevds that htees dtso weer ossi!bmero

\ * \ yB “tcveia ,sro”bsmoie I juts eman isesmobor ni eth repscos of teingconrv RmAN to ireo!tpn (aWth we acll nta”ltorn“ais ;)

orF a arteg iettll summyra fo eht smEnpilcdao uclRemuti n(ad nyma herot csptecon ni locearulm go,bloi!)y ees shit mrof rb’esltA lroleuaMc ologByi of eht ellC:
psm0wnv.k/8n.ii2/s/w.44tBAclbn1o/g/2#o6K:h.No2wbht

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drdoom  ^ m'I tsju -eatgirsnt in neo mecnmot wtah I owret in tlpuliem becusnmtsmo obave: /oeecm9sm4s/sx3am2ta3t/e9/:e.1/mhnr#79wnbbnp +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

+/- drdoom(1206)

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submitted by therealslimshady(42)
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nheW tnpierso gienb dmae ni het ER ,dmsfiol they mcuealauct ni het E,R wchih enth eirsgtrg hetm ot be ptsi uot otni het oycltso adn oebcme adgerdde by p.reetasmoso uhTs, het mnaiutacuclo of eth sfolidmde irenpot in teh ER si durrqiee rof tmhe to utallmteyi eb ggdeat yb itnuuqibi dan be eedadrdg in oeotsmpas.re

nevE if oyu rageu ttha htey wlil be nugctalmacui ni hte scolyot ecbsaue smeteposaor rae in the ooly,stc the uosqetni is nagiks reehw are teh srenotip tiagcumclnua, ton ebign eaddgred. So yhet at'cn mluacuetac ni ,sasoeepmort ecesaub hety aer sorddteey ni t.ehm

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drdoom  enci cctha hiwt teh t“inuccmu”aagl re!rkam ,qq nwhe ouy yas sgrte“igr mhte ot be ptis tou otin hte tcyosl,”o od you eahv a soecur for t?tah no'dt alecrl relgiann ahtt nhreeayw .meslfy xht! +1
therealslimshady  I n'tac berreemm rheew I raed isht btu ti kcsut hiwt em, I htink it swa a lelc obi kobo +


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submitted by mutteringly(33)
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siTh is ofmr b:somsa Maettud RFCT neeg 85ΔF(0 tm)tinuao → sildefmdo tnoprei → vecfteedi roipnet is tadeeinr in eht guhro amdcpsnieol ciuueltrm E)(rR rfo adrigtndaeo → -gePtATda doeichrl nehcnal si anetsb on eht clel seracuf fo lhlpiieeta celsl urthhgtoou teh byod ,..e(g tinitesaln dna itpaeyrrosr lipeh,itea tswea ,sdnalg ionerecx ,anpesarc eoeinrcx aslgnd of vdurcietepor )rgnosa

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submitted by unknown001(9)
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TRLUA ISPL.EM

.1tereh are mnay ivrtaasn fo scyict fiossrib os shit isnoeuqt is not taoub sp.ahyhpty of CF

ot.pi2n fo tqeuoisn : ewreh edos neirtpo lofnidg uoccr ? awn)sre RRE

  1. NI SHTI YTEP FO CF , fi ipotnre tinos eldfod eprrylpo ni RER wlil ti og otu ro lliw it cculeamatu ? ans)wre ti wlli umuctleaca ni R.ER

ITP : FI UYO EPEK REHRIACNGES ON RTIVSNAA FO FC, YOU REA ON A HATP TO SESDELN ODMO

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submitted by blah_blah(1)
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hfe lpulwnhicniIytNQ=c3jgb:tayovsp_?syepc.oma&a//wHuBXbeaugest.fwh/tlhnouGao;=mlw

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submitted by welpdedelp(270)
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/iymov2oM5cP.7/sg9nn2.k2_d5_o/049_mh1924lM1.Fini22Cs1sTp38H=eb?s2t.5neeL3380/1__1ppw//3:gh0at/ggs5ier92n

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