For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I heva na essui tihw shti sneqtiuo ichhw salo nfcoltcsi iwht Wl.rUdo nI edorr ot eb dedargde by ooeerstospm eth dimoeflsd eorntip loduw dene to eb esrntep in het styoolc fro iuatn.obiun It ti mtaldeccuua in the ERR hent who deos ti egt ?gagdte nHeots,yl so etnlc.iof.d.c
hTe FRTC eoptinr si a remetnambrsan r.oinpte ikLe lal netro,sip sti oaslatnnrti siebng ni eht c;yostlo ttah dsi,a TFRC isantcno na nu-Nmisret ig“lnsa ”seueecnq, hicwh smnea sa it is bengi ntlt,daarse it n(ad hte riosembo nakgim )!it illw eb psertdaornt to hte limcapsdEno emuutcli.R^tenfoo!ot
sA ti tegs slearntta,d tsi hrodcoiypbh mtosif lwil ,meeegr cwhhi seemdb hte FTCR itonerp tnihiw hte dlosopiipphh yiblera fo het ER tilf!es atTh nemas teh tonrpie iwll ervne gaain eb dfuno “in hte socyo”lt ubaesce ti tesg eredtahd togrhuh het aiylebr ih(hcw si, in aft,c hwo lla mnrseaberamnt eritspno bmceoe maemenbnratrs eirtpnos at hte lecl rasufce -- yeth haev ot eb dmea tnio rebmarnnamets eotpnsri in eth RE !rf)sit.
So, ey,s telymali,ut hetse ddfmelois tpsnoeri ilwl eb edeitdcr rodwat a maptoeeors fro dn/cnlraggriyaoceed,ti utb ahtt lliw eahnpp sa a tetlli eeclvis o(r pm“ol;oeis”) hte fsmdleoid teon,rip in stih aec,s si ton euab-relslotw s(eic,n yb iit,oneindf it sha oroiydpbchh fsotmi hcwhi etg ehtrde“ad ”uhrgtoh a lrybiae ot trecae eht eatmenbsnrram rp)tt,aen cihwh seanm yuo twn’o idfn ti ni teh .scotoly
\ tnooftoe! \ ehT ihtnchgi fo at*veic bmrissooe ot eht ipaEsncolmd ueRmtilcu is yhw ew clla ahtt eara of ER ug“roh moniapEcsld utuiRclem r”(;)ER on lneocetr ,omcopriscy ttha nitcoes saw edbeseclpk whit tltiel ;dsto ater,l we sahu)m(n eocdirevds that htees dtso weer ossi!bmero
\ * \ yB “tcveia ,sro”bsmoie I juts eman isesmobor ni eth repscos of teingconrv RmAN to ireo!tpn (aWth we acll nta”ltorn“ais ;)
orF a arteg iettll summyra fo eht smEnpilcdao uclRemuti n(ad nyma herot csptecon ni locearulm go,bloi!)y ees shit mrof rb’esltA lroleuaMc ologByi of eht ellC:
psm0wnv.k/8n.ii2/s/w.44tBAclbn1o/g/2#o6K:h.No2wbht
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
nheW tnpierso gienb dmae ni het ER ,dmsfiol they mcuealauct ni het E,R wchih enth eirsgtrg hetm ot be ptsi uot otni het oycltso adn oebcme adgerdde by p.reetasmoso uhTs, het mnaiutacuclo of eth sfolidmde irenpot in teh ER si durrqiee rof tmhe to utallmteyi eb ggdeat yb itnuuqibi dan be eedadrdg in oeotsmpas.re
nevE if oyu rageu ttha htey wlil be nugctalmacui ni hte scolyot ecbsaue smeteposaor rae in the ooly,stc the uosqetni is nagiks reehw are teh srenotip tiagcumclnua, ton ebign eaddgred. So yhet at'cn mluacuetac ni ,sasoeepmort ecesaub hety aer sorddteey ni t.ehm
siTh is ofmr b:somsa Maettud RFCT neeg 85ΔF(0 tm)tinuao → sildefmdo tnoprei → vecfteedi roipnet is tadeeinr in eht guhro amdcpsnieol ciuueltrm E)(rR rfo adrigtndaeo → -gePtATda doeichrl nehcnal si anetsb on eht clel seracuf fo lhlpiieeta celsl urthhgtoou teh byod ,..e(g tinitesaln dna itpaeyrrosr lipeh,itea tswea ,sdnalg ionerecx ,anpesarc eoeinrcx aslgnd of vdurcietepor )rgnosa
TRLUA ISPL.EM
.1tereh are mnay ivrtaasn fo scyict fiossrib os shit isnoeuqt is not taoub sp.ahyhpty of CF
ot.pi2n fo tqeuoisn : ewreh edos neirtpo lofnidg uoccr ? awn)sre RRE
ITP : FI UYO EPEK REHRIACNGES ON RTIVSNAA FO FC, YOU REA ON A HATP TO SESDELN ODMO
hfe lpulwnhicniIytNQ=c3jgb:tayovsp_?syepc.oma&a//wHuBXbeaugest.fwh/tlhnouGao;=mlw
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$279$49I khtin mero lnrge,leya oirpnte ignofld hppesan at eth ERR dna eth smet ysas eht noriept odt’ens lodf rlyprp.eo aic,yfllSiepc the smto moncmo CF ntaioutm si a ofieddmsl riotnpe dan het peiotnr si deeinrat ni het RER nad ton oanptdrrtse to teh llec abnemrem - FA 9210 gp 06.
$279$49