I hinkt more ryleae,nlg teoprin liodngf hppnsea ta the RER nda eht mtes yass teh eoitnrp tesdon’ dflo epr.oplry efcacli,Siylp teh toms onmmoc FC tmounait si a msdfdolei noprtei adn het oinrpte is eaedrtin ni the ERR dan otn prrtonsdtea ot hte lelc eebrmanm - AF 2901 pg .60

ehT FTRC tenrpoi si a esartnamnermb ret.pnoi Lkie lla ns,oitpre tis solanrttnai isbneg ni the yo;clots ttah ad,is CFTR onistanc na rtinNuem-s “glnias e,c”qesuen wihhc smnae sa it si bngie an,dsatelrt it (nda eth misobeor gankim t)i! iwll be rrspanettdo to hte iplomEasdnc ^mRliteuu.cooefto!tn

As ti gste ,nrelttsada sit hypbohidrco otimsf wlil rgme,ee hwich eedmbs eht TCFR ntrioep tiiwnh eht ohspipdoilph brailye fo teh ER leitf!s thTa nmaes the poretin liwl nreev aanig be fondu “ni het oy”olcst seaebuc it sget edrtahed thrghuo het beiaryl w(hich i,s ni acf,t woh all ansarntremmeb tiorpens ecbmoe meesnarbnarmt rnopiset at het cell ferausc -- yteh avhe ot be aedm tino tnaemrnasremb esnirotp ni the ER itsr.)!f

,oS sye, lleyia,ttum thees diofdmels psieontr iwll eb ddcteeir wtador a eoroatsepm for iaeenco,l/adricygndgrt btu taht llwi appenh sa a tiletl cvliees (or ”;mplsooi“)e the msifddleo otirep,n ni htsi ,esac si ton lsrtlow-beaue ,in(sec yb n,ifeontiid it ahs hpioybdhcro tfoims cwhhi gte “eatddreh rhouh”gt a aleybri to teearc het samnrtreanemb nrt,e)tap hhicw emsan uoy ’nwto infd it in hte slcooyt.

\ tooetnof! \ eTh chngtihi fo *viecta ibmsesroo to eht mlnEoiapcsd elictRmuu si yhw ew clla htta area of RE urgoh“ nsipdEoclma mRieutcul R;)”(rE on nreloect csyiocpomr, ttah ncoitse wsa epeslkbdce hwit teiltl otsd; al,ret we unm)hsa( dcdoeirves hatt htese dtos erwe biso!somre

\ * \ yB ce“taiv ibse”osrmo, I utsj emna oiremboss ni teh scespro of toigcvnner mANR ot priote!n th(Wa ew alcl tnln”as“ratio );

roF a rgaet illett rsmmauy fo the lEocnimpdas cmRuitleu a(nd many htoer occnpset in celomural bl,go!)oyi ees ihst rmfo bst’relA uolalecMr Bgolioy fo teh lelC:
mnhc/4K/v21hiws.6Ap0tonnbN8w.Bso4b.2:w/.ilk//go#2t

heWn sroipten gnebi edma ni the ER s,lmfodi htye tlauceucma ni the R,E hihwc htne rirgtges mteh ot eb stip uto oint the tlyocos dna obceem reeddgda by rpeae.smstoo hu,sT eth auclcauonitm fo eth lesidodfm tireopn ni the RE is reiqeudr fro hmte to yeutaitlml eb gdegta by iiqiuuntb nad eb edrgaded ni aooemserspt.

eEvn fi oyu reagu hatt hety lliw be cugnltciauam ni eth ootcsyl esuceba omtsapereso rae in het st,clooy eth esuqiton is ignask erewh rea eht rpesiotn nuuglcmtaiac, nto nigbe raeddgde. So hyet cant' maccleuaut ni tsmeras,eopo sbuceae teyh aer oytsrddee in te.hm

ihTs si ormf :osbmsa utatdMe FTRC eneg (F5Δ08 tmutni)ao → foeldsdim roeintp → eeevtfdic epntroi is rtiednea in eht horgu onslecpdmia mulurtiec E)(rR rfo odtgandaier → geP-tAadT orecldih hcelnan is seatbn on hte llec feucsra of ehleipalti cells ruugtohtoh het doyb ,eg.(. lteiinsant nad rsareroyipt teiilpaeh, setwa lda,gsn crnexeoi ,sraeancp cxeoiren sgdaln of irteerupvdco ns)oarg

TALRU LM.ESPI

teer1h. rae yamn tavsainr fo ccsyit irssfboi so stih tuqneios si ont butoa hts.apyhyp of FC

npito2. fo toeuiqsn : ewher dsoe rtinope gdilfno curco ? )nrswea ERR

1. NI THSI YTPE FO FC , fi tinoerp stoin loedfd orpylrep in RRE illw ti og otu or liwl ti aulatmeccu ? n)eawrs ti wlli uueacacmtl ni .RRE

IPT : IF UYO EPEK EASECGRNRIH ON VNASRTIA FO ,CF YOU RAE ON A HTPA TO NELESDS DOMO