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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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icraense in MPcA G(s) - bt2ae - lindovisatao

rseeeadc ni MPAc (G)i - alpa2h - ticnovotnoasrsic

eisracne ni 3PI ADG q)G( - l1haap - cntrtoisaoonivsc

cesiaren ni PGMc - M3 - ON eduicnd tnaovsliaiod

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cytotoxict  hpAal 2 osntiags od tno uaces tctoanvnsooisicr bc/ etyh ldea to vaneegit kbdfeeac fo prnoie nda usth eedarces ihtmyespatc ossperen +1
payingforthisisdumb  02FA p371 iฮฑsatsgno2- acenrsei /PNcMGO and taaesidvol +
sarahs  ywh si eiecdarsng APMc onrwg? +1
hiroshimi  as:rash@ uoy antw ot crsaeein APMc euasecb ti odlwu alde ot oisianvlaotd dna plhe to secdeear ihs lbdoo rss.uerpe anecgrDsei PcMA dwluo aemk shi BP eswr.o +
fatboyslim  ahlap2 taiumoltsni seascu tilsnavodaoi acubese it si ytith.msalcopy +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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THN ecrgmeney, iSdomu strpiNeu.riods kleiUn ryzlehaadni a dcanelab aotlorsivad v(nie = )loiarert

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sympathetikey  eWll ,then I esgsu ew osdluh ujts getofr btoau our odl lasp eth l2Ah-pa osotgs di.oaGn la.lc I idtn'd evne see atht htsi asw rnhseeiypvet cegyerm.ne mDbu on ym .trap +
zup  os eay noidelinc wdlou eb euds ofr ehsyerpintev ,ycngure tbu hist ugy si oevr 018 (0)12 so hyte aehv ot esu gntsomhie lkei adzlaienyrh ro sderupnitrosi thob liwl ceraeisn PGMc +
whoissaad  Dsgru usde to reatt TNH lepacarno aCuinpdnndatbceti NrdgeCii:Nnedme ld rlopspieoevim yine rlsoeoFLilei +18
lola915  enaHdralizy alltucya laisodvseta rvt&r;taeeniesigs dan Npdrustriieso slaoeatvdis aetsreir = evni.s tBoh icsearne .cGMP +12
vi_capsule  OS thsi ties oesg tfear nymoe o!wn at astle ym tmnoesmc 'reatn baecmrlds lol +2


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