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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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ainreecs ni PMcA )Gs( - ta2eb - lvsdoaaiinto

seaedrce ni cMPA iG)( - 2lapah - atcoovotnniissrc

caeserni ni 3IP GAD G)q( - ahal1p - nootsnoivacisrct

criaeesn in GMPc - 3M - ON ceidndu ivsoanlidaot

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cytotoxict  Ahpla 2 tgsnsoia do tno euasc icrvntsatooncosi bc/ yhte dlae to ngtieeva cadbeefk fo orpeni nda uths decersea tmcesaypthi epsoensr +1
payingforthisisdumb  2FA0 731p stg-is2aonฮฑ seicerna ONGMPc/ nad vsaidleaot +
sarahs  hwy is criagedesn cPAM rwngo? +1
hiroshimi  @raahss: yuo antw ot eiscnaer AMPc auecbse ti udlwo ldae to itoavslnioad nda lphe to ascerdee hsi oodbl .eerpsrus Dcseagreni AcMP wlodu eamk hsi PB .orswe +
fatboyslim  l2phaa snuiioatlmt ussace oitaavlnsoid ecebaus ti is yysl.mitachopt +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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NTH ecre,gyemn mduioS irdopNseistur. ekUlni eyhainzardl a labcnaed oliastroadv i(ven = t)eroailr

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sympathetikey  leWl tn,eh I esgsu we hlsodu utjs ferogt btuao ruo ldo pals het a2lph-A i. ooGdossagtn llac. I n'dtid nvee ees ttha isht wsa rpiveenestyh gremecen.y mubD on ym rpa.t +
zup  so yea iclniedno dulwo eb euds rof hirsyveteepn nueyg,cr ubt sith guy is rove 801 )102( so yteh ehva ot ues heosgmnti iekl hlarzydaein ro rnureiipsstdo hbot liwl eescainr MPGc +
whoissaad  Dgrsu edsu to ttear HNT lCliavni r : NocemersicarginedpoylponNieCle eoFd timbu nsdoerpnLlendaieitpieda +18
lola915  aniadlrHyze ltlyuaca leoadtsvasi vei&itasre;ntgers adn Nistdpsouerir asitlavdose ietrsera = eni.sv Btoh eacreins GM.Pc +12
vi_capsule  SO ihts teis eogs aefrt eyonm won! ta tslea ym menosmtc ne'rta rbecmasdl llo +2


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