NBME 21 Increasing cGMP (NBME Answers)

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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP 🔍 / 📺 / 🌳 / 📖
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+9 upvote downvote
submitted by ∗divya(75)

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sranceei in cAPM )s(G - bta2e - oodntiailsva

scaeeedr in cAPM iG() - 2pahla - ittanvioorcsnosc

nceaiesr in PI3 GDA G)(q - 1phala - ttricocsvainoson

erascien in McGP - 3M - NO dncdiue alaootndvsii

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cytotoxict halAp 2 agsnsoti od nto ceasu ovronsocstatinci cb/ ehty ldae ot atieveng fabdekec of iprone adn utsh cerasdee eyhscimpatt osrpenes +1

payingforthisisdumb 02AF p713 intg2-osasα nrieesac /cPOMNG dna svieaaoldt +

sarahs why si eriedgcasn PcMA ?onrwg +1

hiroshimi ras@h:as ouy natw ot rsceniae AMPc sebeuac it lwudo adel to iodanaoitvsl and help ot aeseecdr ish bdolo .esepsrur rcseDgaein cPAM lwdou akem his PB erso.w +

fatboyslim pa2hla nmltsiatiuo sasuec nloisavidato asbeuce it is hsltpaimcyyto. +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)

+1/- b1ackcoffee(115)

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+2 upvote downvote
submitted by ∗vi_capsule(21)

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HTN ee,crmgyen oumSid dpisuNtioresr. ekliUn dilyarahzne a ncdalaeb aaodslvirot en(vi = ater)irlo

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sympathetikey Well e,hnt I gseus ew dhuosl tujs forteg oautb rou dlo pasl eht phaAl2- .Gitsa odosong .call I intdd' nvee ese atht itsh wsa tiephversyne y.menrgece Dmbu no ym part. +

zup so yae ncnioiedl ulwod eb edus rof yhseipentevr cuyrn,ge btu sith guy si veor 810 (021) so teyh veha to sue tgshomnie leik haieyzrdlan or iousprnrtesdi thob wlil eercanis PMGc +

whoissaad srDgu edus ot artet HTN ne NtdrendlreoNLeloselurpFdpn i:lcbee dmyo Ceeiaiivat cropgpm idinilCsnoiaaein +18

lola915 dearHzainly llcyatau asiosaevtld srnes&;eattiivegr nad tspiNesroruid ioeaalstdsv ersireta = e.isnv Bhto cnrseaei cPM.G +12

vi_capsule OS ihts ties geso etraf oeynm wo!n at tslae my cnemtoms ane'tr asdrmlecb llo +2

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