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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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enaicrse ni PMcA s()G - abet2 - ioodvtaaisln

eeerscad in PMcA G)(i - phlaa2 - vactsrioooisnntc

acesrien in 3IP DAG )G(q - 1alaph - nsctoiocvasntoir

nreecsia in GMPc - M3 - ON ndecdui sdoanitaoliv

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cytotoxict  lhApa 2 naosigts do ont ueacs sasctoincrtovion c/b tehy aled to eagtevin dekbcfae fo eproin dna hstu aecdeers tiachmpseyt espnseor +1
payingforthisisdumb  FA20 173p ฮฑt-ogs2anis ncseriea cOP/MGN adn eaodltvsia +
sarahs  yhw si encaigresd MPcA gw?nro +1
hiroshimi  ah@rssa: ouy anwt to eesranci cAPM sbaucee ti uwodl lead ot ivsidtaoaoln nda leph to rcasedee his olbod e.ssrepur esDcniraeg cMPA udlwo emka ish PB .esowr +
fatboyslim  lap2ah oimutantsli acsues atnioaodlisv csuebae ti is omp.atytslyich +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)


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 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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NHT eycegnme,r mdoiuS s.prsdieurNoti Uielkn eardyzailnh a blcenaad dtolroaasvi i(ven = iorar)tle

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sympathetikey  lelW ,enht I gsesu we hsuold jtus ftoger bouta uro dol lpsa het p-2Alah nsGto.dooiag s cl.al I id'dnt neev see tath hist saw rnhvesipeeyt .eyeegrncm bDum no my .aptr +
zup  so aey enlicdino wloud be sdue for sietyreevpnh ngcuyr,e btu tish ygu is oevr 018 )01(2 os ehyt vaeh to ues tieohgmns klei ynalhzaerid ro pirnssudoriet obth lilw eencisar PcMG +
whoissaad  rgusD euds ot rtate NTH lotdtrageiFnNclliebCimno:i l edeaLiorn pocedps mrnadiirnlae uNpey eieiodCepvns +18
lola915  naylriadezH ulaactly devtaiosasl esetrr;teivag&sni nad dNrspiiteuros aaoldstveis treeasir = in.evs hotB neaisecr Mc.PG +12
vi_capsule  SO iths esit soeg tafre menyo !own ta alste my esomctmn n'aetr slerdamcb llo +2


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