For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I ehav na euiss wiht htis inuqsoet ihwch lsao icfolctsn hwti lor.UdW In redro to eb agdededr yb rsetosmpeoo het lsfeidomd oipertn udwol deen to eb pentsre in teh loctsyo ofr aituubonin. tI ti cdaamctuule in the RRE htne woh odse ti tge etgadg? l,Hstenoy so .ilcot.dce.nf
hTe FTRC pteinor si a tnbmarneamres t.epnroi kieL all ,tnoirpse ist tnaasniorlt bgnsei ni hte styclo;o taht s,adi CTRF niatosnc an esmnNritu- gn“ilsa ,ncsueqe”e iwhhc asmne sa ti is bnige ntata,lrdes it dna( the irsbeoom maikgn t)i! liwl be ttorsanpedr to teh npasmidoElc ^uelimRtuc.tof!oneot
As it gtse sat,rdenalt ist bhiyhrcodop smioft ilwl eger,em hhcwi mdeebs eht TRFC epirnot iwinth hte ilppdohspiho lyiraeb fo eht ER ilset!f tTah nmsae het rtenpoi wlil rneev aigna be fduon n“i hte olcsty”o abucsee it egst ddreetha ogrhhtu teh bylaeri icwh(h is, ni fca,t who lal arernemstabmn tinspoer beoemc arrmentmansbe esrponti at hte elcl ucsfear -- eyht have to be adem otin benrmreanastm tsnrpoie ni teh RE ).srtfi!
oS, esy, myatieu,ltl eesht edlsmodfi nitpreos lilw eb ctrdieed wtraod a aeetoormps ofr aadgyngrtecnliieod,cr/ tbu that will nhppae as a tlleit levscei ro( e“s”ml);opio hte dfemoldis i,notpre ni shit ,ecas si tno w-eurtsloebal ,esc(ni yb odintei,fni it sha hcpdrohybio msifto hwich teg deer“thda orhuht”g a bilerya to cetare het entaanrsbmmre t,pnret)a wcihh emsan you now’t nifd ti ni hte toscyl.o
\ tenfot!oo \ eTh ctighhni fo etaic*v oersmbosi ot het imdscoEpanl uitcmuRle is why we clal ttah reaa of ER ugro“h aldcpmsniEo lmuucteRi ”(;)RrE on eenlroct myccoi,rosp thta cisotne asw seecldebpk ihwt iltlte t;sdo l,aret ew msahu)n( svreidodce atht seteh tosd eewr obm!eoirss
\ * \ yB e“ctavi i”mrobs,eos I jsut maen riomssbeo in hte rcssepo of ginoevntcr NmRA to netro!ip Wat(h we call satoi”na“nrtl ;)
rFo a getar lttlei armsuym of the pasEonldmci uetRmuicl d(na mnay thero otspeccn ni lomreulca b,)yigo!lo see hits rofm bAetsr’l luMelarco Bliyoog fo teh elCl:
8p2.swbi2hbtBn#sNo0lvo./in/c4:n4/hwt2/w6o.kK/g1Am.
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
heWn oipetsnr gebin mead in eht ER msoifdl, etyh ueaccamult in eht RE, wihch enht gsgirert hemt to be spti uot onti the ostcoly nad becmoe daeergdd by aeesptsoo.rm Th,us hte uaclmiactnou of eht msilfdoed enrtoip ni hte ER is ueedqrir rof hmte to tilumtylea be tgadge yb itiqiuunb and eb regddead in smoeopters.a
vEne if you gurae that yeth lilw be gcanlcauitum ni eth tycloso csbeaeu srotseoepam era in eht yt,colso teh niuetoqs is kignsa reewh ear hte otspirne imtuanlaucgc, nto ngbei radedged. oS htey 'cnta elcamatucu ni p,taomrsseoe beesuca hyte rea yrstddeeo in .thme
hsiT is ofmr :smsaob tuetdaM CTFR egen Δ(F085 o)mattniu → simdeofld iornpte → eidefcetv tnoperi si nridaeet ni eth rgouh dalmincsope ueuimcrlt r)R(E rfo idaoegrnadt → aTedA-Pgt rchieold ealncnh is bnstea no eht clle ecaufrs of elilpthiae escll urthgoothu eht doyb (e.g,. tiatlnneis dna rtarosyripe ,ieielthap taesw nad,lgs exoircen sareacp,n oieexrnc nlgsad fo eturcoirvped )oanrsg
ALRUT .MSIPLE
1er.teh are anmy ntisraav of tiscyc irbosisf os isht otnieuqs si ton otaub ya.tyhspph of CF
2ioptn. of qintsoeu : hwree edso irepton ilfgdon corcu ? aewsr)n RER
IPT : IF UYO EEPK RASICEHNREG ON TRAISAVN OF F,C OYU EAR ON A APTH TO DESNLES DMOO
puflhel w?peIsehtm/va/ilgugjwbunfs=.oawaQ.Xtylou&=h;_yto3Byt/bmpicGnoenNaw:Hcscah
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$279$49I htnik rmeo gll,reenya ierpont gdionlf nheaspp ta the ERR adn het smte ysas eht poerint otedsn’ lofd ppeyr.lor caflSiclepy,i teh omst noommc FC atinutom is a misolefdd nepiort and eth poniret is daeneirt in eth RRE adn otn oanrrtsdtep ot het ellc nreemamb - AF 0912 pg 06.
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