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Retired NBME 24 Answers

nbme24/Block 3/Question#46 (reveal difficulty score)
A 15-year-old girl with cystic fibrosis has a ...
Endoplasmic reticulum 🔍 / 📺 / 🌳 / 📖
tags: cell_bio cell_transport cell_trafficking protein_folding

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 +7  upvote downvote
submitted by vshummy(184)
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I htnik rmeo gll,reenya ierpont gdionlf nheaspp ta the ERR adn het smte ysas eht poerint otedsn’ lofd ppeyr.lor caflSiclepy,i teh omst noommc FC atinutom is a misolefdd nepiort and eth poniret is daeneirt in eth RRE adn otn oanrrtsdtep ot het ellc nreemamb - AF 0912 pg 06.

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uroosisyed5  hWich akems sseen fi we hitnk buaot eth phtoapshy fo ledveate Cl- dna aN .irlncalrlleuyta Bhto fo etshe iosn og pu sidein het lcles edu to eht iornnette fo eht lsdiedmfo sneroipt ni hte ERR. +
lilyo  I uctalaly iedasreg hwti tshi ganirsnoe. ehT lpoptohhyayisgo in FRCT si nto ued ot lumaiatccnuo of ilsdomdef .nrtesoip tI is deu ot tsbe/ddeseeaancr PTA tadge mmaesenabntrr ioCehldr e.hanncl ccdnArgio ot drolU,w the ddimsceo pontrei is eeetddct by het iolandsEpmc Riemtlc.uu hTe manalbro rnitope si aeettrdg orf nortdteusci by eht rtaeoopmse nad rvene cheaers het llce .fsecrua Teehr si NO rteitneon of fdielsodm iro,npte theer si odatnredgai of lmdfeidso itonrep dan oefeherrt ebscnea of dlhrecio nshcnela on het e.amernbm Thsi is twha salde to diamprei omavrle of tlsa mrof het atswe as elwl as ecreaddse laNC in u.mscu I odnt ithnk eht naewsr shulod be .RE Can ynnaoe eltl em if I am igsnsmi hneitsogm eher ahtt kmaes teh rasnwe RE as pdesopo ot p?yltcsaom eacseuB hte wya I see fi si sodimdfel tisnoepr og morf eht ER itno teh plmatsocy ot echar teh rpoasmotee adn tehn eb etdtcur.esd lUrowd usqntieso ID rae ,805 280, 1145, and 31.99 +19
drdoom  @oylli ehT CRTF si a bensarremmtna tprnioe. ekiL lal opierst,n tis iartaotnsnl igsnbe ni het olstcy;o atth a,dis RTFC insotanc na ir-eumNnts asgnli“ ”een,qesuc hhwic anems sa ti is nebgi lt,sneardat it (nda het bmeoiosr animkg ti)! illw eb tapodntrrse to the pnEscdialmo toot^!lc.tnmeRfeouiu sA ti gtse trnles,adat ist oryibhphdco sfiotm ilwl meee,gr chihw bemesd eht CTRF enritpo hniitw teh pioiodppshlh yrlabei fo het ER l!ftesi ahTt smena eht tpieron lilw enver aaign be dofun ni“ het oocls”yt ebecasu it gest hetdrdea routhgh eth blireay cwhh(i i,s in f,tac who all namtanbemersr teispnro cobeem atebnmmrnesar itesnrop ta the llec ucsfaer -- htey aevh ot eb mdea tino nbenmsetramar spenotir ni eth RE .)i!rfts +11
drdoom  iloyl@ ietdn(o)ncu So, sy,e taul,tmeliy heest eflsmoidd tronpesi lliw eb irdedcte wtardo a omtpearose rfo g,oyncerlnareiidadc/gt btu ttah lwli eanphp as a leltti elvscie (or ;l)p”ise“moo hte oiedsdlmf pitno,er ni hist e,sac si nto rlwutble-eosa e(in,sc yb neifoiti,dn ti sha hyporbodchi tmsoif ihhwc tge ar“edehtd ugohthr” a bleiyar to cetera eht mnrrsemanetab tp,a)rnet hwchi smane ouy ’tnwo idnf it ni eth ysolto.c +6
drdoom  o^oeo!nttf : eTh noemvtme of *ctivea iosmbsroe omfr the olsytco ot teh lcdniaoEmsp umuceitRl is wyh ew allc taht eara of ER “ruhog psEmdncalio umeilRutc ;rR”(E) no retecnol iopy,csmcro ttha enscito saw peesekdbcl twhi titell ost;d aelrt, we m(sna)hu sdcevdeori ttah seeht dtso rwee eirsmb!oos +1
drdoom  * yB ae“tvic oiebsom”r,s I stuj enam semsorbio in teh secsrpo fo igcoervtnn NARm to tp!inroe a(htW we lcal “onttansilra” ;) +1
wrongcareer69  How mnya nddgoam yasw rea eyth inggo ot tets su on F.C I'm so vroe s!iht +2
furqanka  losa ni AF, rdenu phaal 1 sniytatr,nip tis yass lifsdeMo'd neeg rtpodcu rnpeoti gergtaaegs ni latcleraheulop ".RE mtgih be eht ames ecpocn.t +9
joanmanuel26  gocndArci to palKn;a lAl siotenrp that era ytneeshzdsi in hte ER smut flod yctrolrce in orred to be retpnarodst ot het iglgo pautasra nad neth ot trihe liafn itsasneino.dt If eht ntatoimu sucae a elodifsdm eitr,npo the ulters illw eb eht sslo of eht etoirpn onifntuc ,dan ni semo ce,ass tnlaoumciauc fo het entpori in het ER. +1
drdoom  yilol@ niTngikh otbua sith ro.em oYu llwi otn indf het osmd)(felid tiproen in eth soylt.co eTh doifmsedl rtpnoei may eb eisidn a pdnrmooes—taea a repmeosato may ivel in teh bl—yotcsuot het dmoedifls rinoept eltsif illw enver aarpep ni eth otoysc.l hTe drptsouc of its tedraniaodg mgiht ucnett(iosnt aomin idsac or lamsl eespdt)pi but if oyu hda na otyibadn rfo eht fldiemsod ortinpe nda eksda ti eW“rhe si hte mdfiedosl ,per?io”nt hte yodiantb wduol wn:eras “tsMo of htwa I lcdou dnif seppara ot eb ni the Rr”E. +
yesa  hCkce tou het aixnnlce lcye,c uluasyl esntirpo atht are eadm in hte RER and sldoifemd get gtgead dna 'rl'fdeedo adn hetn aenscnd anaig rfo eorprp na.difn.ogld. if yeth yeallr natc' eb edlf,roed yether' ddadeerg neht nda !reeth oS het nlyo aclpe fslimddeo FTRC cduol caluutceam fi deslofdmi ER..s..i...R Link( to elaicnxn yec:cl DHm/&0s&aaw&wi:DtjlAYj/guecr1QXi6wsa=bQ2ahB;ag=c4a0QaQh8Aa5e=xhems1mKoY8ga+mL71U5Hof8rmo;Q;UI21hAi=U79myUcEMer:Zor=bTag_gZwds;tmWbCps=s2mrp4oD/sil5pVhiIgsxR7p0Uiua3pEbKj8wcgrK=s.IhMmCA&h;e=vLea;F;OeOrqvmXtV73p8HtAho#9=&2+PBpl?np&94e.&5aIckmnw) +
amy  200FA2 4:7 " tebAns or scoadlyfinntu RSP na(slgi itnoioenrcg teplri)ac tsulsre ni cacuaoltnuim of reipnto in eth oy"slcto +
drdoom  my,@a ’stath a doog optni ubt it seasmsu hte ntrepoi si eerhostwi lmrno,a ,..ie ton dmsfodile ro b“arnlaom” in emso erhot ywa +

For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204

+/- drdoom(1206)


 +4  upvote downvote
submitted by seagull(1933)
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I ehav na euiss wiht htis inuqsoet ihwch lsao icfolctsn hwti lor.UdW In redro to eb agdededr yb rsetosmpeoo het lsfeidomd oipertn udwol deen to eb pentsre in teh loctsyo ofr aituubonin. tI ti cdaamctuule in the RRE htne woh odse ti tge etgadg? l,Hstenoy so .ilcot.dce.nf

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sajaqua1  So yioadlinrr a desdmlfio iortepn esod uogenrd itinbqianuotiu and lpeyoir.osts tI si eanobelt atht FCTR nldfmiisgo tns'eod even lawol it pecaes het ,ER os ti maceauuctls ni het ER +9



 +4  upvote downvote
submitted by drdoom(1206)
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hTe FTRC pteinor si a tnbmarneamres t.epnroi kieL all ,tnoirpse ist tnaasniorlt bgnsei ni hte styclo;o taht s,adi CTRF niatosnc an esmnNritu- gn“ilsa ,ncsueqe”e iwhhc asmne sa ti is bnige ntata,lrdes it dna( the irsbeoom maikgn t)i! liwl be ttorsanpedr to teh npasmidoElc ^uelimRtuc.tof!oneot

As it gtse sat,rdenalt ist bhiyhrcodop smioft ilwl eger,em hhcwi mdeebs eht TRFC epirnot iwinth hte ilppdohspiho lyiraeb fo eht ER ilset!f tTah nmsae het rtenpoi wlil rneev aigna be fduon n“i hte olcsty”o abucsee it egst ddreetha ogrhhtu teh bylaeri icwh(h is, ni fca,t who lal arernemstabmn tinspoer beoemc arrmentmansbe esrponti at hte elcl ucsfear -- eyht have to be adem otin benrmreanastm tsnrpoie ni teh RE ).srtfi!

oS, esy, myatieu,ltl eesht edlsmodfi nitpreos lilw eb ctrdieed wtraod a aeetoormps ofr aadgyngrtecnliieod,cr/ tbu that will nhppae as a tlleit levscei ro( e“s”ml);opio hte dfemoldis i,notpre ni shit ,ecas si tno w-eurtsloebal ,esc(ni yb odintei,fni it sha hcpdrohybio msifto hwich teg deer“thda orhuht”g a bilerya to cetare het entaanrsbmmre t,pnret)a wcihh emsan you now’t nifd ti ni hte toscyl.o


\ tenfot!oo \ eTh ctighhni fo etaic*v oersmbosi ot het imdscoEpanl uitcmuRle is why we clal ttah reaa of ER ugro“h aldcpmsniEo lmuucteRi ”(;)RrE on eenlroct myccoi,rosp thta cisotne asw seecldebpk ihwt iltlte t;sdo l,aret ew msahu)n( svreidodce atht seteh tosd eewr obm!eoirss

\ * \ yB e“ctavi i”mrobs,eos I jsut maen riomssbeo in hte rcssepo of ginoevntcr NmRA to netro!ip Wat(h we call satoi”na“nrtl ;)

rFo a getar lttlei armsuym of the pasEonldmci uetRmuicl d(na mnay thero otspeccn ni lomreulca b,)yigo!lo see hits rofm bAetsr’l luMelarco Bliyoog fo teh elCl:
8p2.swbi2hbtBn#sNo0lvo./in/c4:n4/hwt2/w6o.kK/g1Am.

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drdoom  ^ m'I tsju setanitr-g ni noe eontcmm wtah I rewot in iptlulme ommesuctsnb eo:vba /eb.mew:s/917no/4em3mr/3tenahtpsn/#ba2x99smc +

A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257

+/- drdoom(1206)


 +4  upvote downvote
submitted by therealslimshady(42)
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heWn oipetsnr gebin mead in eht ER msoifdl, etyh ueaccamult in eht RE, wihch enht gsgirert hemt to be spti uot onti the ostcoly nad becmoe daeergdd by aeesptsoo.rm Th,us hte uaclmiactnou of eht msilfdoed enrtoip ni hte ER is ueedqrir rof hmte to tilumtylea be tgadge yb itiqiuunb and eb regddead in smoeopters.a

vEne if you gurae that yeth lilw be gcanlcauitum ni eth tycloso csbeaeu srotseoepam era in eht yt,colso teh niuetoqs is kignsa reewh ear hte otspirne imtuanlaucgc, nto ngbei radedged. oS htey 'cnta elcamatucu ni p,taomrsseoe beesuca hyte rea yrstddeeo in .thme

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drdoom  ecni hctca whit the mu“c”caugialnt !akermr ,qq nwhe uoy ysa “gsterirg thme to be sitp uto toin the tclyo,s”o od uyo ehav a rcesuo orf tath? dtn'o elalrc nrgelian thta wrheeayn yme.lfs hx!t +1
therealslimshady  I a'tcn eemmrreb ewrhe I erda htis tub it tckus iwht em, I kihnt ti asw a elcl oib book +



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submitted by mutteringly(33)
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hsiT is ofmr :smsaob tuetdaM CTFR egen Δ(F085 o)mattniu → simdeofld iornpte → eidefcetv tnoperi si nridaeet ni eth rgouh dalmincsope ueuimcrlt r)R(E rfo idaoegrnadt → aTedA-Pgt rchieold ealncnh is bnstea no eht clle ecaufrs of elilpthiae escll urthgoothu eht doyb (e.g,. tiatlnneis dna rtarosyripe ,ieielthap taesw nad,lgs exoircen sareacp,n oieexrnc nlgsad fo eturcoirvped )oanrsg

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 +0  upvote downvote
submitted by unknown001(9)
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ALRUT .MSIPLE

1er.teh are anmy ntisraav of tiscyc irbosisf os isht otnieuqs si ton otaub ya.tyhspph of CF

2ioptn. of qintsoeu : hwree edso irepton ilfgdon corcu ? aewsr)n RER

  1. IN IHTS EPYT FO CF , if ptinoer nstio oddefl ypolrrep in ERR ilwl ti og uto ro ilwl it temaucaluc ? resnw)a it ilwl eutamulcac in R.RE

IPT : IF UYO EEPK RASICEHNREG ON TRAISAVN OF F,C OYU EAR ON A APTH TO DESNLES DMOO

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submitted by blah_blah(1)
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puflhel w?peIsehtm/va/ilgugjwbunfs=.oawaQ.Xtylou&=h;_yto3Byt/bmpicGnoenNaw:Hcscah

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submitted by welpdedelp(270)
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/14t1psP?=igit0322_idos3iT2.9/n5en29_/54m0psL/hn5Crw/3hgMn5s8sk8/9__:.79.2o11n/b.mg_3o022evy12MeeHpFgcla

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