For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I eavh an sisue hitw stih nueitosq hhwci laso lctsiocfn wthi ldUorW. nI doerr to be dadgreed by spmtsoooeer eth dsfledomi pteiron ulodw ndee ot be eeptrns in het tosylco rof naouibut.ni It it aaucmltdecu in hte RRE ehtn who edos ti egt gga?det tlH,oseny os fn.o.il.ccdte
ehT FCRT reonipt si a aranmmesentrb onet.rpi kLei lal srnptoe,i sit rtaionslnat ingseb ni hte tysoloc; htat asd,i RTCF sinoatnc an mesiNtrn-u “lgnsia eenqu,e”cs hichw senam as ti si niegb ltd,raneats ti (nda hte eroibmso kmiang !i)t illw eb eastprdotrn ot eth soinlmpacdE Ru.tumeli^coetnooft!
sA it estg edaraslt,nt sit rocyhohdibp otmsfi iwll meeger, hwhic esbmed hte FRCT rtpineo hniitw eth ipopslohhpid iyalber of the RE flesti! taTh msean hte peornit lwli neerv gnaia be odfnu n“i teh tlcsyoo” aceuebs ti etsg htdreeda gtrhouh the ibealry hi(chw si, in f,atc how lal meenbrratsman tepnoirs oecemb mreramnstenab tirnosep ta eht lecl eucfsar -- thye aehv ot be mdae onti mebrmarnnstea tosrnepi ni hte ER s.!ftri)
,So es,y uemallt,ity teesh molsfdide nesitpor will eb ereditcd dotraw a stomroaeep fro nig/glnr,caridcaeeotdy utb that lilw hpaenp sa a ttiell lieecsv (ro li”e)m;s“opo the mleidfosd otnpe,ir in hits ecs,a is not reltlou-easbw (ic,esn by ifid,tnnoei ti ahs hyrpcidbhoo iomtsf iwhch gte ehd“aedrt hhgtrou” a ibyarel to caeert eht emrnsenartabm enrp)ta,t cwhhi nasem uyo n’owt dnfi ti ni het otcyol.s
\ !nftootoe \ hTe ihtchgni of iavt*ec miosbrsoe to hte Esmdnaoilcp Rucimutel is ywh ew alcl ttha eraa fo RE uoh“rg noapcEdlism lcRtimueu )”(E;rR on cnrteoel csociomr,py ttah ocsneit wsa sbdelkpeec ihtw titlel ts;do ,relat ew (uah)nms cievroesdd tath ehtse sdto eerw ebr!mooiss
\ * \ By ita“vce obmrei”oss, I ustj amen oersomibs ni het eosrpcs of iontcrnvge mARN ot pi!rtnoe Whta( ew lcla rionn“”ttasal ;)
orF a tgrae tiletl srumaym fo het osicmnEplad mRltuecui nda( naym rtheo ccpeotsn ni ealcorulm i!oy,)obgl ese thsi mfro lsrtAe’b laMorucel oylBoig fo teh leCl:
bs/n/nioiw1nAo6cwwvg2kN#tmKt82.4:B./l2/h.o/b.ph40s
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
Wenh etprinos ginbe edma in eht RE mdisl,fo htye uctecuaalm in hte R,E whhci tenh isrgtger mhte ot eb itsp tou iton hte lcootys dna becoem dreeagdd by reaotpmosse. s,Tuh the ctimuluancao fo het idlmdsefo nroeipt in hte RE si irdueeqr rof hmet ot liauemlytt be aedggt by uuqtibini dna be degdrdae in tprosomeaes.
envE fi uoy graue ahtt hyet iwll be ltanugmcuaci ni teh toslyoc scbeeua emproaseots era in the tloo,syc hte qesutino si ksagni werhe ear eth rtpeonsi ncuucagltmia, ton bigne degeddar. So yeth can't cemcluatau in stsp,meaooer aeusceb ethy ear edtedsyor in ht.me
isTh si mofr sabo:sm aMudtte TRCF eneg (50F8Δ tonaium)t → mleifdsod neporit → tveiecfde otipenr si derienta in eht rohug saepdlncomi ilcmetruu r(ER) for dergtaiadon → ga-deTAtP ihecldor nehacln is staebn no hte llce esfucra of hielatipel slcle tohugouhrt eth dboy e,(..g tseatnilin nda psaotryerri aili,eepth stawe dl,sang nreoxiec nare,csap eoirxnce lgdsna of oeutrcidpver s)gonar
RTAUL P.LEMIS
th.eer1 rea nmay ivraasnt fo cyscti sofbiirs so tsih stoiqneu is ton tbuao pys.pthhay fo CF
poin.t2 of nuiqstoe : erhew odse etrpino lfiongd crcou ? )rensaw RRE
PIT : FI OYU KEEP ENRASREGHCI ON NIVRTAAS FO C,F OYU REA ON A HPTA OT SLENDES OOMD
l efhlpu.cfo/aevpmH3osajspQumwn=liiyNcotGh/esc=y:hyw?hw&u;neIbwo_gbaanaXutlt/tgB.
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$279$49I itnkh rome e,rnaeyllg otpinre lngidof nspphae at eht RRE adn het mtes sysa eth noerpit setod’n oldf .rrolppey cl,lcSypafiie hte msto mcnomo FC taoutmin is a disemflod rtnoeip nda hte tonepir is tareeidn ni the RRE and otn otnrpdrseat to eth lcel mnrmeaeb - FA 1209 pg 6.0
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