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NBME 22 Answers

nbme22/Block 4/Question#14

In patients with adenosine deaminase deficiency, ...

Ribonucleotide reductase

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this image shows lymphocytic toxicity.

this image shows that the buildup of dATP inhibits RNR (ribonucleotide reductase), which inhibits the rest dNTP synthesis.

bonus image shows RNR is the target of hydroxyurea.