NBME 22 Helicobacter pylori (NBME Answers)

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Retired NBME 22 Answers

nbme22/Block 3/Question#17 (reveal difficulty score)
A 50-year-old man with chronic gastritis is ...
Helicobacter pylori 🔍 / 📺 / 🌳 / 📖
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submitted by ∗usmleuser007(464)

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1) EBV = Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, 1° CNS lymphoma (in immunocompromised patients)

2) HBV & HCV = Hepatocellular carcinoma

3)HHV-8 = Kaposi sarcoma

4) HPV= Cervical and penile/anal carcinoma (types 16, 18), head and neck cancer

5) H. pylori = Gastric adenocarcinoma and MALT lymphoma

6) HTLV-1 = Adult T-cell leukemia/lymphoma

7) Liver fluke (Clonorchis sinensis) = Cholangiocarcinoma

8) Schistosoma haematobium = Bladder cancer (squamous cell)

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some0217710 Aren’t both H.pylori and EBV associated with gastric lymphoma? +4

baja_blast You're right that EBV is associated with gastric lymphomas, but this is specifically asking about marginal zone lymphoma (or MALToma) which is associated with H. Pylori, not EBV. https://www.ncbi.nlm.nih.gov/pubmed/11552717 +2

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submitted by ∗haliburton(224)

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FA 2017: H pylori is associated with gastric adenocarcinoma and MALT lymphoma

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seagull I might be mistaken but I also thought Epstein Bar Virus was also implicated in gastric lymphomas? +13

iwannabedonewiththis yes but the one in this question,Marginal zone lymphoma,is specific to H.pylori FA 2021 439-1 +

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submitted by ∗link981(208)

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Marginal zone lymphoma is caused by CHRONIC INFLAMMATION. H-Pylori can cause chronic inflammation in the stomach.

Epstein barr virus is associated with BURKITT lymphoma, the JAW lesion in Africa.

Got it wrong because I thought H-Pylori only caused gastric cancer.

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