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Retired NBME 22 Answers

nbme22/Block 2/Question#47 (reveal difficulty score)
A 22-year-old woman who is at 16 weeks' ...
Down syndrome ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—armymed88(49)
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Down syndrome 2nd trimester screen (usually around 16-18wks) shows decreased AFP, estriol and increased hCG and inhibin A.

Of trisomy 13/18/21, Down Syndrome is the only to have an eleveted hCG

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makinallkindzofgainz  "Down Syndrome has high HI (hCg and inhibin)" the relationship between the words down/high really stuck for me +2
drzed  An easy way to remember the other aneuploides is that the "lower" ones (e.g. lower than 21 = 13,18) have "lower" values (e.g. LOW hCg and LOW inhibin) +4



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