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NBME 22 Answers

nbme22/Block 2/Question#18 (23.7 difficulty score)
A 32-year-old man comes to the physician ...
Reverse transcriptaseπŸ”
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 +4 
submitted by b1ackcoffee(35),

as @mtfp said, NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance.

Need to put as separate comment as wrong explanation is at top.




 +2 
submitted by adisdiadochokinetic(74),
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sihT qistnuoe is so ygnnaoni but iths txnoeialpan is rpdtupseo yb eserlav apsper.




 +1 
submitted by lamhtu(113),
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tI aseprpa ttha auhtoglh ITRsN era hhelyrtodasopp by tmieinhdy aknsei, cientasrse is luytlaca ude to tuismanot ni eth auclat errseev citsnrstaarpe traher ahnt imhyiendt senkia etlsfi.

forerofore  mutations in thymine kinase are more frequent in herpes drugs +3  
mtfp  NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance +10  

as @mtfp said, NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance.

Need to put as separate comment as wrong explanation is at top.

+/- b1ackcoffee(35),


 +0 
submitted by jessikasanz(4),

What does Zidovudine act on? It is a rev transcriptase inhibitor. Resistance often occurs at site of drug activity.