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NBME 22 Answers

nbme22/Block 2/Question#18

A 32-year-old man comes to the physician because of ...

Reverse transcriptase

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submitted by lamhtu(31),

It appears that although NRTIs are phosphorylated by thymidine kinase, resistance is actually due to mutations in the actual reverse transcriptase rather than thymidine kinase itself.

forerofore  mutations in thymine kinase are more frequent in herpes drugs +  
mtfp  NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance +  

This question is so annoying but this explanation is supported by several papers.