Kim! Hi! It’s your dad!👋 ▪ Khalilah, I’m proud of you for taking a risk for your dream.Everyone’s explanations tend to be so on-point, and the commiseration makes me feel better, too—thanks for the support & good luck studying!                       want to add a message here? just email us!
share email twitter ⋅ join discord whatsapp(2ck)
Free 120  NBME 24  NBME 23  NBME 22  NBME 21  NBME 20  NBME 19  NBME 18  NBME 17  NBME 16  NBME 15  NBME 13 
search for anything NEW!
NBME 22 Answers

nbme22/Block 1/Question#5 (29.2 difficulty score)
A 10-month-old girl is brought to the ...
Naloxone🔍,📺
tags:

Login to comment/vote.


Tutor box

Members from the Leaderboard offering 1-on-1 help: Want to be listed here? Email us!

 +2 
submitted by d_holles(198),
unscramble the site ⋅ remove ads ⋅ become a member ($39/month)

hsiT utosiqen dofcsnue me bc I houthgt arleidpmeo cuold otn srosc hte BBB and fhterreoe oclud tno ucsea oeptaysrrir spoeednsir iuo-ip(mod masgino at hte nsamtibre tueslsr ni aytsCrNrpriSeo/ ,pieoesrsdn .1) Btu .xx@rd si ceotrrc ni ignotn taht ↓ RR nad CSN pserideons in het tP ohudls lacl fro na -poimoiud igasonntta arehrt athn ahlohetncb mehiinim(ccoo)lt to aertt np.asitnoctoi

  1. =:sr?.qy2og6i.piss.ct9esatlxhrp7r0taoslto/h/5etp.auinbls5hgadcieae/a
nwinkelmann  http://medresearch.in/index.php/IJPR/article/view/782/1271 This explains a case in an infant. "Respiratory depression and coma after overdosage have been shown to be reversible by injection of naloxone [6]. Owing to its structural similarity to opioid, loperamide toxicity can be reversed by using Nalaxone which is a specific opioid antagonist acts competitively at opioid receptors. Naloxone hydrochloride is usually given intravenously for a rapid onset of action which occurs within 2 minutes." +3  
yb_26  FA 2019: "Loperamide has poor CNS penetration" - so it still penetrates => can cause respiratory depression +4  
whoissaad  Also maybe because the blood brain barrier in a baby is not developed as well as in an adult. +4  



 +1 
submitted by pingra(4),

I looked at it this way:

A ten month girl receiving adult doses of a mu agonist (which has POOR CNS penetration not zero) could probably have some adverse effects

I then read that the kid has a decreased RR (10/min) and marked abdominal dissension (prob due to the fact that opioids slow peristalsis; sketchy pharm also says opioids can lead to biliary colic)

Figured naloxone would reverse these symptoms




 +0 
submitted by syoung07(38),

Loperamide is a Mu opioid agonist that can be used to tx diarrhea. It doesn't cross the BBB so theres no chance of addiction but you can still see the effects of opioid overdose I believe. So tx opioid overdose with naloxone.




 -2 
submitted by dr.xx(157),
unscramble the site ⋅ remove ads ⋅ become a member ($39/month)

oNarml seorirparyt aert orf a 01 htmno old &;gt 05 hrabste per ueitnm.

noaxoeNl oludsh eb nvige in eht pesrcnee fo yoprsraerti ossieerpdn nad yam ruqreei arepteed oig.snd

sw.m.p9w0wgo/mc2niv/ihuld:.b563/4ttnb./he8pn