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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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ereisnac in MPAc ()Gs - 2taeb - niolvtsiaoad

edcarsee in MPAc )(Gi - a2hlap - nvaiocsostticnor

scnaieer in IP3 DGA qG)( - p1ahal - ositocarontisncv

erciasne ni MPcG - M3 - NO deniduc osvailitaodn

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cytotoxict  Aalph 2 atsonsgi od otn eacus aisvtrnotniccoos /cb htey elad ot gtaievne efbdeack fo eropni and hsut ardeesec phatysitcme srsopnee +1
payingforthisisdumb  20AF 17p3 s-isaฮฑgnto2 eacrnise cMNG/PO adn isavoedtal +
sarahs  wyh is rascegndei PcMA rgw?on +1
hiroshimi  ash@sar: yuo tnwa to caereisn PMAc esbucae it dwlou ldae ot iladnastooiv nda lhep to eadcesre hsi lbdoo esreprus. sncDegriae cAPM dwulo eamk shi BP row.es +
fatboyslim  a2lpha tminiotlusa aseucs altoiadisnvo ecabuse ti si plmactysh.tioy +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)



 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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NHT ecgye,mern omduSi ssiirtopedNur. iklUen arnldihayze a alenacdb daartvoislo i(vne = tir)oerla

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sympathetikey  Well tnhe, I guess we losudh tsuj erfgto aobtu ruo ldo pasl teh plA-h2a goitaoosdn.Gs a.cll I tndid' eevn see htat iths wsa esynheitverp mey.crngee mbuD on ym tpa.r +
zup  os eya ndnioiecl ldouw be dues rof vhetseyirpne gercu,ny tbu hits uyg is orev 801 21)0( os htye heva ot sue smegintoh liek ehdzraianly or rissntdoperui htob llwi neeaicrs McPG +
whoissaad  rugsD edus to aetrt HTN epmni u e cNbilNnricid ansindFeCtedioierpeeplgalyvtrieorlomilnLdaeaooen C:s dp +18
lola915  niHyaldzera alltuacy iaetvsdsola &erigreasvs;iettn and ueidprirNsost svatesdoail retieasr = i.evns otBh arienecs G.McP +12
vi_capsule  OS itsh seit gsoe trfae nemoy w!no at teasl ym moestncm rtea'n edslbacmr lol +2



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