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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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eeacnsir in MAcP )s(G - 2teba - tsiinvooldaa

eedsecar in AcPM i(G) - l2apha - itctcvooaiossrnn

aceerisn ni PI3 DAG Gq)( - ha1lap - oosnacrnistvcito

aineecrs in cMPG - 3M - ON cdudine vatioonisadl

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cytotoxict  Aphal 2 sagntois do nto sauec snonaircsoocvitt cb/ heyt edla ot nveetaig bedfekca of rnpeoi and hust darcesee satcimeyhtp nsesrpeo +1
payingforthisisdumb  F0A2 73p1 isgtns-2ฮฑao cnsieera Oc/GNMP adn dsaeloavit +
sarahs  yhw si cgnreisaed cPMA w?ngor +1
hiroshimi  @rs:haas uyo tawn ot eiscraen PAcM aubesec it dlwou dlae ot osalaondtvii adn lpeh to csdaeere shi oodlb re.rsesup eDrinceasg cMPA wudol maek his PB s.orew +
fatboyslim  hlapa2 tiimsnuolta causes atslanovidio cbaeseu ti si hytytiapmsc.ol +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)



 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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TNH engrcye,em mdiuoS rusNrdop.tsiie ieklnU irlyzaeandh a danleabc aldatoisvro eniv( = reatoil)r

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sympathetikey  eWll neht, I sgeus ew uolsdh stuj oftger uatob uor dlo lasp teh pa2lAh- asGondg.so oti l.lac I ndi'dt evne ese htat sith asw peieeyrnhstv n.gceymere Dbmu on ym tpa.r +
zup  so eay dlnceoini wudol eb euds ofr prtvseeyeihn gcnruey, tbu hsti gyu is voer 108 (10)2 so yeht eavh to seu tsmgohein ilek adezrlynhai or rsorusdepniti btho iwll ciesenra MPcG +
whoissaad  gusDr esud ot tetra HTN to :veiedlnoL ci ependeru inpidcipyeFraeeoiCo gldaendNimominnsrbllipesNalarCt +18
lola915  nrlHzaeaidy luylcata stadlivasoe at;v&eiersiesrtng dna tpserodrNisiu ievsaodslta erisater = nisve. tohB naeecrsi PcM.G +12
vi_capsule  SO stih ties eogs erfta yomen wn!o at slate ym mocemstn 'arnet lmabredcs llo +2



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