NBME 21 Increasing cGMP (NBME Answers)

Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP 🔍 / 📺 / 🌳 / 📖
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+9 upvote downvote
submitted by ∗divya(75)

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caesiern ni cMPA Gs)( - eb2at - aisivdnlotoa

asredcee ni McPA Gi() - hap2la - orvansiiocntocts

iacrenes ni I3P DAG (q)G - a1plah - scnsocoaivtroitn

nsareice ni GcPM - 3M - ON edudinc savdlooiniat

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cytotoxict lhApa 2 gantssoi od otn useac otrcnioasstniocv bc/ ethy dlae ot gvetneai ekdabcfe fo eoipnr dan tshu srcedeea mphtaysciet reonseps +1

payingforthisisdumb A2F0 3p71 tiαsn2sa-og caneirse cGNPMO/ dan taeilsovad +

sarahs yhw si aesrdgniec MAPc o?wngr +1

hiroshimi s@aah:sr you atnw ot iesrecan McAP caeesub ti uolwd laed ot soatlidnavio adn hlpe to eraeesdc shi obdlo .rusrespe csearDigen cAMP owdlu make hsi BP eor.sw +

fatboyslim palah2 aoiuttlimsn susace liitoodvasna uasebce ti si thyyliosp.mcta +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)

+1/- b1ackcoffee(115)

+2 upvote downvote
submitted by ∗vi_capsule(21)

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HNT ng,emcryee dmiuoS rsiteprusiodN. nlkeiU lyzadnrehia a nbcdaael aioorstvald vn(ie = ratole)ri

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sympathetikey lleW tn,he I gsesu we oslhdu juts geofrt obtau ruo odl slpa hte p2-lAah aonisodg.os tG a.llc I d'itdn neev ese htta stih aws vryhesetipen ece.egyrmn muDb no my trpa. +

zup so eay nidlnieoc would eb dues rof vrsieehtpney ruyg,nec but tish uyg is evro 108 12()0 os etyh vahe to ues ntosehimg kile dhnzrayeail ro siiontprsduer hotb ilwl censiear GcMP +

whoissaad sgrDu edus to reatt HNT lie: eapabNeit lllnaLcpneCniidys ee mpoiii unCa rredrsprdionomieevdogtceloFnNd +18

lola915 anlydizrHea acyutlla tasaioevdsl a;tissvientgerr&e adn tisdriNeupsro etsvaoildsa teirsaer = niesv. Both ancsieer .PGcM +12

vi_capsule SO siht seti sgoe atrfe nmeoy !nwo ta seatl ym tcsenmom ert'an damrlsceb lol +2

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