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Retired NBME 21 Answers

nbme21/Block 1/Question#48 (reveal difficulty score)
A 44-year-old man is admitted to the hospital ...
Increasing cGMP ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +9  upvote downvote
submitted by โˆ—divya(75)
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eneirsca ni PMAc s()G - teab2 - soaviolnadit

dsceeaer ni AcPM i()G - hlaa2p - osnricsotivotnca

rniaseec ni 3PI ADG q)G( - aap1hl - oitcannsvcosorti

escieanr ni GPcM - 3M - NO ndcduei ivosaantdiol

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cytotoxict  Aahpl 2 igstsona do ont ucsea assootiintcnocrv /bc etyh ldea ot vganetie efakbecd fo ieronp dan hsut ceesdrea eytiasthpcm sesropne +1
payingforthisisdumb  0FA2 71p3 ao2siฮฑst-gn nsceaeir GNcPMO/ nad ldevaisato +
sarahs  wyh is ecesdngiar PMcA rog?nw +1
hiroshimi  @harss:a ouy atwn ot eneiarsc MPcA abceesu it udlwo lade to vtalidoainos and help to daeecser his obold rse.upers egnieDsarc AcPM ulowd make ish BP s.rewo +
fatboyslim  hlaa2p ouiamltitsn aceuss lviaoanitdso ubeasec it si ylmachottps.yi +

simple rule of thumb is

Calcium --> vasoconstriction (smooth muscle constriction) -- > must be Gq (alpha 1, v1)

rise in cAMP and cGMP both vasodilation (cAMP by inhibiting MLCK, cGMP by activating MLCP) so whoever causes vasodialation must increase either. cGMP is niche (NO, ANP) so most of the time it is rise in cAMP --> must be Gs (beta 2)

only exception is M3 it rises calcium (Gq) but in endothelial cells , not vascular smooth m. cells, so NO produced and causes vasodialation via rise in cGMP (again!)



 +2  upvote downvote
submitted by โˆ—vi_capsule(21)
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TNH yn,mgeeecr ioSmud iespNst.rrudoi liUenk heylnaiazdr a dcblaean aoltsardvio eivn( = rl)iatero

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sympathetikey  elWl ,ehnt I esgsu we hludso sjtu efogtr toabu ruo lod apsl teh p2-ahlA ndgo. Gtasoois allc. I nditd' even ees taht isth asw vyieteersnph yeem.cengr Dmub on my apr.t +
zup  os aye dinelonci owdul eb seud rfo enryhtpeevsi ,yrngecu utb htsi ugy is vero 810 120() os hyet evha ot use ogtinemsh kiel alyhzinarde ro psurtrnesdioi hbot llwi icseeanr MPcG +
whoissaad  sgDru ueds ot rteat TNH dpoeiNclbieno tieLrgdandltlicnFrem edeeo rp:Cepaoymi eCllu ioaindnrpssinveiNa +18
lola915  Hinzedrylaa atuylacl sodvilastae g&ar;ieetntevsrsi and trdsirNpsoeui asldsvaoeti eeirsatr = nv.eis tBoh sarnicee .cMGP +12
vi_capsule  SO hsit siet osge rtefa nyoem n!wo at aelts ym oecntsmm tn'era clsarbemd oll +2



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