For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I hvea na usesi wiht shit qsetoniu cwhhi lsoa stcoifcnl tiwh doWlr.U In order ot be eedgdrda by serotpeoosm het edimlsfdo penriot oudwl ened to eb srtpnee ni het clsotoy rof it.innaouub tI ti malecduutca in eth RER neht how osed it etg at?gdeg ysnH,etol os c.ltonficed..
ehT RCFT neptiro si a rentsremnaamb iop.netr eLik lla spin,orte ist natolniatrs ingbes in eth oy;lscto thta dsa,i CRFT stcnnioa na Ntuensmi-r si“nagl ,ecnuesq”e hcwhi esmna sa it si ginbe tnseatrad,l ti dan( hte soremoib mangik ti)! lilw eb tnoetrpsadr ot the nmacslodEpi lRm.ieucut^oo!notetf
As it gtes adnl,aesrtt tsi dhirbycpooh fomits liwl e,meger which sebedm the CTRF epnotir iinhwt het hploiphpsdio bliryae of eht ER etsf!li Ttha emnas eht riepnto ilwl neevr aagin be ufodn ni“ eht c”soolty bueacse it setg tdhedear thrhugo eth yabelri w(cihh is, ni tcfa, woh lal nsambertamrne rnetsiop ebmeoc btesnaermarmn epsrtoni ta teh ecll efacrsu -- hyet vahe ot be amde itno rmtnnaebasrem petsroni in teh RE fts.i)!r
S,o sye, teyatm,ilul ehest sedfdlimo treoinps iwll eb rdtcedei orwatd a meesptoaor rof dceidgetra/rnygo,iclna btu htta llwi neppha sa a leltti icevsle (or p”)o“em;islo hte odldemfsi rpoi,etn in sthi ec,sa is ton olueabwlrste- nsc,ie( by f,eiiidntno it sah bhyriodophc mtofsi ihwhc teg eertdd“ha ”grhhtuo a iyarlbe ot eatcer hte aemrbenamtrsn p,tea)rnt chwhi enmas ouy o’tnw infd ti in teh ltsooyc.
\ nteto!foo \ ehT tgnihich of iectv*a ressioomb to het odpnlEscami tlcuumRie si hyw ew alcl ttha eraa of ER r“uhgo pcEnsmodila ieuRcmult rE);(R” no eroelcnt ,oomccyirps that toncesi aws lbcpeseekd whit ttelli otsd; ,lrate ew usnam(h) socdevderi htta htese osdt erwe !rsmooebsi
\ * \ yB ac“tiev o,beirsmo”s I jsut mane obemisors in the srsecop of nenrcigovt mRAN to !oirptne tW(ah ew allc ats”rialtnno“ );
For a terga tlietl rsuamym fo hte cndlimsEaop lteiRcumu na(d yanm hrote tpscneoc ni aluoremlc yli,!oo)gb ees tshi rmof strbeA’l eoaclulMr oiogylB of eth lCel:
.820vb6.nng.scnoo2t4KmNhA:w/p/tw4/Bwosib.hk2/#1li/
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
Wenh sprtieno neibg dmae in eht RE sf,mdlio they alctumuace ni hte ,RE whcih thne trgseigr ehtm to be sipt uot otin eth ysotocl dna cmeobe agededrd by eo.tomperssa ,hTus het uunaccotmila of the esddlifmo noieprt in the ER is erqrieud for ethm ot etiatullmy be tdaegg by qiunbitui dan eb eeddrgad in sepsatermoo.
Eevn fi uyo aeugr thta tyhe wlli be umautalncgci in eht otslcoy ueacseb osseprteamo aer in the ,olcstoy eth nqtoisue is iskang rehwe are the rsepnito ainuacutmgcl, ont gnebi dderdaeg. So hety tc'na teacuaclum in amstsrep,ooe ebeucas yeth rea ertosddye in mt.eh
Tsih si rmof msosb:a tauetdM RCFT ngee F(0Δ58 an)utitmo → ilofsddme pientor → ieeefdcvt eornipt si eieandrt ni het urohg clispomenad ilutrceum R(rE) orf neddigtraoa → a-PdAetgT cedlhiro anlechn is basent no het llce efucras fo ltehalpeii lslce tghotruuho hte odby .g.e,( esianitntl nad oitraysperr iehipetal, ewtas dnlga,s xeoicner e,acsrpan xoinrece gldsan fo evteruicorpd sgoa)rn
UTRLA EI.MLSP
eer.t1h rea mnay atrvsnai fo syitcc sbrisofi os isth neiqtuso is tno utboa pyashhtpy. fo CF
o2nipt. of esqontiu : rewhe osed oepirnt linodgf ruocc ? se)anrw ERR
ITP : IF OUY EKEP SGIECRHANRE ON AATSVINR OF ,CF UYO EAR NO A TAHP OT SDEENLS ODOM
fuhl lepg&/sbQf_/nyps.Gyb=I?i=amlmuhiuacetycHt.ovgpttweXowhuajNheaww3oBa;nno/s:cl
submitted by ∗vshummy(184)
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$279$49 65% OFFI ktihn erom anl,ereylg tonperi gnlfido ahpesnp ta het ERR dan the mste sasy het iretopn st’odne fldo orlyrepp. llSccif,piyae teh osmt omomcn CF tonaumit si a lddefsomi nipteor dna hte nptrioe si iaertend in teh ERR dan ont ostprdanetr to teh llec raneebmm - AF 0219 pg 6.0
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