rSeum ssikcens is a peyT 3 seihstyentvripyi tcre,nioa in cwhhi the bdyo prsdsone to cntaigine lcdeami ntscsasbue nad dersopuc bitae.osdin eTseh otiasnbdei in cirtlcnouia hten dbin ot eth cgateniin dugrs nad tse ffo teh pmntloeemc a.ccdsae hodeaRiumt rraitshit si sloa a Tepy 3 yhsiisttinvepyer ae.ciotnr
)A osppAoits fo aompsgr-aech staioopps is negreyall otn a yetp fo rheiissiepyvtytn aer.ticno )B Msta ecl -uatngeindrola iths si rapt of a epyT 1 sttpniyhysiireev ilaanacahxsenyrot,/pi ni which tsma cells dibn IgE on ehtir sr,ufcae dan EIg ginibdn ot hte raetgt tigenna sdeincu a cnlormatoanoif nhcega in the gEI ahtt etss ffo atms llce eatldr.gaonuin )C lNtuaar lielrK llCe kl-glini plays a yeiartv of ,orsle gndiulcni naeccr ispsnuroesp dan crestonutid of ryvilal fneitedc lesc.l If tehy paly a oelr ni syye,ristnitphevi it is rapt fo ypeT 2 SHR in wchih yteh owlud rdnpeos to gI on the clle crus.fae )E lWeeh dan faler rcn-sioaet hiTs is salo a yepT 1 S.RH
bumping the OP; extraarticular manifestations are common in RA (i.e. rheumatoid nodules in subcutaneous tissue and lung (+ pneumoconiosis --> Caplan syndrome), interstitial lung disease, pleuritis, pericarditis, anemia of chronic disease, neutropenia+splenomegaly (Felty syndrome), AA amyloidosis, Sjogren syndrome, scleritis, carpal tennel syndrome. (btw I thought RA was local and HSR II)
Mbaey htey ntwe wtih murse ikecsssn (a ypet III yytnsispethiirve xrn) no hsit uoiseqnt daseb on teh gyooserl edsu ot deisgaon .RA tPs iwth RA ehva isoietnabd to gniommliubounl G )GIg(, leadlc eahtuimdro caofsrt FR.)s( It smaek meos nsees htat noup esteh dmoairehut sfctaor cgrintae twhi "e"sfl gucitrlanci ,gGI meinmu oclpsmexe ouldw rfmo tath woudl etrla estodpi in situses iix(anplegn ni ratp eth ilrettrxauacar fastsnomeiniat nsee whti ,AR e.x mtheiuarod ue,osldn sritiupl,e esrarcdiitip e)c.t.
/mieic/p/nrepeotytdieipat:insytnsotsed-yce-dicch/ecisnniecrt.ihsmwi-rwvdite.wtispy/t-
Serum sickness—the prototypic immune complex disease. Antibodies to foreign proteins are produced and 1–2 weeks later, antibody- antigen complexes form and deposit in tissues = complement activation = inflammation and tissue damage. Fever, urticaria, arthralgia, proteinuria, lymphadenopathy occur 1–2 weeks after antigen exposure. Serum sickness-like reactions are associated with some drugs (may act as haptens, eg, penicillin) and infections (eg, hepatitis B).
RA si a type 3 evsiieriyyhnstpt onairetc cwhih sha otw ootecnpn.sm
CD +4 T lslce llwi eilrtantif tsusie nda rtace ot oungnetiatas eretsnp in hte onlsvyia jitno, this eucsas aNlhF-Tpa dna -IL1 to be es.rldeea hseeT ariomaftnmly oistnyeck lilw sueca teh nilitia amnoyftariml oan.tcire eTehs nkosceity OLSA eittcava B celsl.
B escll podecur ihtamruedo rctfao as llwe as aitn icccly ttiadlrlinuce deippte iyd.abotn yehT ibdn hte atgstunioean and from UMEINM mxpsleeco tath potiesd no eth umosiy.vn heyT cesau onmleetpmc ot be vdictaea.t eeHnc het clssiac ypTe 3 svettseirpihyyin a,conitre ti is cpomosed of 3 nihst:g 1. tangnie .2 ibndtoay .3 pemmteolcn
Ne,tx you deen ot kwno htta srmeu nsecksis )A(F is SLAO a ypte 3 eiihsyysvnerptti iceon,rat hits temi ti is ued ot lceilipinn or a ncoalmlnoo tnao,yibd bialclsay emso tigiacenn ru,dg ihwch ecassu obayndit ot bidn dan then itopeds eetolmp.nmc
epyT III trptesiyvsehiiyn is deindef yb the cepeerns fo gnlcruicati miegonttnbaitmnecpy-ne-ldoa olpeexcsm ahtt dteopsi ni tsusise nad caues mailnioamfnt adn eniutsordct. (esh adh rceeeasdd C)3
epty III iihssetytiynrepv stocain:re E,SL esrmu cnesskis troiaen,c optyeiastlrri oa,onPAN(s)d nad rgeoooSseNpetoalcric-itcnr()-sGlspPhutpl.mto AR is sloa a exmdi Teyp 3 and yeTp 4 H.SR
reSum nisesskc ocrcus enhw a udg,r shuc as hmiyetynto-tca oll,uingb astc as a pehtna ot eth muemni stysem, rggrgeiitn iatnydob r.amoionft euSmr sknsseic careiotn aluuysl scocru 1 ot 2 ekwse tefar het iilitna psoexrue ot het ugd,r ertcilengf the miet ierqrdeu to tnumo an eunimm sees.ronp hTe nibdtiasoe ethn nibd the rud,g sptieod ni ,iuests adn aatrtct and vttiaaec mleneo.tpcm eTh ursetl si e,vefr hrs,a dan rtaiaag.hslr
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