mreSu scnkssie is a ypeT 3 htreyiyspsviinet ire,tanco in hcihw hte byod sonspedr to ntaienicg amcdlie uatbsesscn nda uodcresp sin.otedbai esThe ibosnaitde in uiciacnlrto neth ibdn ot eht aciitngen urdsg adn tse off the oemplntmce ace.csad doRiuethma rasitriht is losa a yepT 3 tstnseheiiyiyrvp .trneocia
A) otopsipsA of corp-hesagam stpospoia is alnglryee otn a tyep of setyiitsihpyervn acenor.it )B aMst ecl -niuoaengtldar iths si part fo a pTey 1 eiityevshptyirns eaionlnyxia,ctrpasah/ ni hwcih samt clsel dibn IgE no erith faruec,s adn gEI iidngbn ot eth tgatre tgnneia sndueic a moconatrlfaion acgehn ni teh EIg that sets fof astm llec a.ulardtoegnni C) ltuaarN rielKl lleC -nklilig spyal a evytrai of r,leso gindiulcn ecanrc poesuprisns dna iotrdsucten of viralyl fcinteed lecs.l If yhte aply a role ni nypiee,vysttirhsi it si rpat fo Tepy 2 HRS ni wcihh hety uldwo dnersop to Ig on eth lelc eua.rfsc E) Wheel dna arlfe -nsoeatcri Tshi si aols a eTpy 1 SH.R
bumping the OP; extraarticular manifestations are common in RA (i.e. rheumatoid nodules in subcutaneous tissue and lung (+ pneumoconiosis --> Caplan syndrome), interstitial lung disease, pleuritis, pericarditis, anemia of chronic disease, neutropenia+splenomegaly (Felty syndrome), AA amyloidosis, Sjogren syndrome, scleritis, carpal tennel syndrome. (btw I thought RA was local and HSR II)
yaMbe eyth twne wthi mresu scesinsk a( pyet III yistntirheipevys x)nr no sthi iqesuont desab no the syogrelo udse to angsiode R.A Pst thiw AR evha snatibdeoi ot ugomilnnmboiul G ),IgG( ellacd huideamtor satfroc RF)s.( tI mksea eosm esnse that upno stehe timaedohur tsfoarc gitrecna itwh "fels" cnugilitcra GgI, memnui pxeocmesl olwud mrfo thta duwlo letra sitodep in suseist lnn(ixipega ni ptra eht uriceartaaxrtl oinafmitatsnes nees wiht ,AR xe. oheaimudrt ,olsdnue tluiprie,s prdeitasiirc ec)..t
whte/pcnpict-tdrehesosy:nipiei--ryw/.pei-tseisocidtiecmt/wdmtetrsyniiciynsen/vdca/.it
Serum sickness—the prototypic immune complex disease. Antibodies to foreign proteins are produced and 1–2 weeks later, antibody- antigen complexes form and deposit in tissues = complement activation = inflammation and tissue damage. Fever, urticaria, arthralgia, proteinuria, lymphadenopathy occur 1–2 weeks after antigen exposure. Serum sickness-like reactions are associated with some drugs (may act as haptens, eg, penicillin) and infections (eg, hepatitis B).
AR si a tpye 3 stesiihyyietnrvp ntoeairc cihhw hsa wot m.netpncoso
DC 4+ T lcsle wlli nfieiattlr isutse dan tarec to easatgounnit epstern in teh yisaonvl nitj,o stih sceaus TaN-aFphl dan I1L- to eb e.aerdesl ehTes tafimlmnraoy ctesoniyk lliw caesu hte tiliani amnmryaltfio ierontca. Tehse cnyiokets ASLO acvtieta B ec.sll
B celsl rpceoud moidrhteau otfarc sa lelw as anti ciyclc iucalriteltdn edippet bd.yaonit eyhT bndi the oannusgaiett dan fomr MUNMIE eospxmecl atth odtiesp on eth iumnoy.vs yhTe ucsae lcmmptonee to be cadtti.vae enHec eht calscsi Tpey 3 pvyiyntitseiehsr iecor,tan ti is odocpmes of 3 si:gtnh 1. aiengnt .2 ainyobdt 3. meotlcempn
xt,Ne yuo edne ot onkw atht smeru eksisncs AF() si OSLA a yept 3 ieetvintyirhpsys rcna,teoi tsih imet it si eud to necilinpil or a olcoalnmno byidat,on bsiaclyal meso gneiacint g,rud hwhci ascues tadioynb to dnbi dna hnet tseiopd penem.mclot
pTey III syyeiihivttperns is iedfend yb eth epnercse of tnlcaircgui tnelaeoitmtnpeagndconibmy-- esxlpocme that dtpiseo ni teuisss dna useca lnfnamtoamii dna eodtsint.cru hse( dha scderdeae 3C)
epyt III ithtnsrvepsyieiy rct:naioes LE,S sruem scssenki ,nareioct tirireatoypls Ao()os,aPdNn dna euictperoG.osmtoorSN-lapsp(-ecPlgritt)nhclso RA si laso a xdime ypeT 3 adn epTy 4 .RHS
meuSr iscssken rouccs nhew a gu,dr chsu sa nyimyt-oettahc lounlbgi, csta sa a hatepn to the euimmn tse,yms trrgieggni bindtoya amfnr.ioto urSme cksesnis ctreaion ulyauls scruoc 1 to 2 seekw faert the iitnial oepsuxre ot het rg,du ltgnerfcie teh ietm eqrriude to tomnu an iumemn respen.os ehT itsbnodiae htne dbin het g,rud edpsoit in e,istsu nad cattatr dan ctvaeati te.clnempom heT esrlut is erf,ve ,srha dan agli.asrtarh
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