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NBME 20 Answers

nbme20/Block 4/Question#32

A 55-year-old man comes to the physician because of ...

Partial oxidation of fatty acids

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submitted by hayayah(525),

Glucagonoma: Tumor of pancreatic α cells Žcausing an overproduction of glucagon.

Presents with 5D’s:

  • Dermatitis(necrolytic migratory erythema)
  • Diabetes (hyperglycemia)
  • DVT
  • Declining weight
  • Depression
killme  And the sixth D: Diarrhea +2  
ergogenic22  a) CAT1 and CAT2 are important enzymes of fatty acid beta oxidation. Glucagon upregulates this process b) glycogen formation is inhibited by glucagon, so that glucose can be used by cells c) acetyl CoA carboxylase is used for fatty acid synthesis and thus decreased by increased glucagon d) glucagon increases ketogenesis +29