fndou isht inelon: o5irk/h/a//a0.m1m0t2ec80are./:urt/h4/9teucasppi0/col5dpmc4y
erycphtiHrop omrypnula oepohtsrhayartot O)(PHA si a mnrdyeos ezccertaiadhr yb het adtir fo tioistps,ier agtiild bcbginul nda ufipnal ttrrhoyahap fo teh eralg itjno,s clysieaple lvgivnino het rwelo biml.s ilCnugbb si hcearzteracid by usobblu eltenreangm of raltienm esngsemt fo eht sgfiren nda oset due to erotfnprlioia of abgusunul innevtocec is.esut
p.r.a.myri is a arre ihatyrreed otnnici.od
A jmaityor fo escas 0&t)%9g(; fo rayescnod HOPA era dcassaoiet hitw ponmalruy smleaigiancn ][6 or rncocih sivuppuetra mpynroalu eadss.eis
ymualPrno eig,cnianmsal dilcgnuni riyarpm []7, aimttacste guln narcce nda tahiricncrota hml,opmay tcnaouc fro 80% of escas fo reaynsdco .PHAO Acoeomnraaincd fo het ugln is eht msto fuenerqt nda lsalm lecl araicomnc si the least nrueteqf aohioitloscthgp tepy of nlug ncaecr escaadtsio iwht OHAP [7].
hetor esicdtaosa aetrtoxchairc angeicmailns enulcid aoeyasgrpanlhn acncior,am arlen lecl ,nacamroci ohsglapoeea ae,ccrn gisctra mruuto ]8[, cpncietaar r,neacc ratesb dlhypoels umtrou ]9,[ e,mmoalna hoidytr cnarce, oamercsaosto dna teiatnisln a.omlhpym
sriVuao mcoliogutrahe isdnoc,otni luiingcdn AR 1,[0] AS 11][, ytriaospilert onads,o LSE [,21] akyTauas sadeies 3][,1 sirodsc,soai SPA dan aMenearenitdr fveer aer nonkw to eb csdaieosat wtih tish dnociitno as lew.l
mrPonyaul tnodinocis shcu as iccyts sir,fsibo sbs,lociruuet daictoipih olurmnayp iirssfbo 14][ adn lgun ntnotsariatplan evah laso ebne tcadiseaos iwth HO.AP
shTi ttipnea ahs hphripcrotye stoyrtptoreahaho which is cdoasteisa itwh corhnegnoibc aarcinomc. tI rpstsene wtih fnaiupl swleilng of s,iwrst firgne,s ke,nals ,sneke ro o.wlbes In iidtnado, hte sdne of lngo bonse wosh tloisearep wne ebno orafoinmt , wcihh can rpudoec ialgdti lgibnbuc nad eonft tsitrirha fo jnaaedct ojnsti.
soRer:cue lanKap eonB ygPlooaht gPae 273
eTh iaesnrpotten of recBgnihiocn ciacrnmao Chgu-oi s adn Tishyemhtse p tuotr stmaeatsis ot gnLo,nie,Brubna nda s. alnadre oS nwo hte tsnioueq si ntinniemog teh asme opitns heT uogch and ptsuum nda loas nwe eobn nfaroitom no cfteeafd bones no Xyar and osla cbnlbgiu steesrnrep eth .glnu
efceRe-rne 001 snecpcot of otamyan esdil 49
epriycophtHr sarthoaopyhoertt is a dmaliec dionctoin gmcinnbio buicnlbg nda tpirssoeiti fo eth mslal nhda nj,siot pslliyeeac hte lidast lengiaetahnaplr ntsjio dna eht tapamaghraeanepcoll ts.iojn tsDila nasxionpe of het ngol boesn as ellw sa uflniap, sonewll isjotn and losiynav usllvio ofipniroletra rae otfne .seen Teh idonocint mya ucrco aeoln myp)rair(, or it yam be erasyondc ot esedsasi kiel lung ne.carc moAgn tnsteaip htwi lngu n,eacrc it is otms cdosaasiet whti dmnrnocaoaieca adn latse sdotcaseai wiht llsam lecl gunl cea.nrc eseTh tsetpnia ftoen get ugicblbn nad ieeracdsn nobe oondetisip on lnog oesnb. rhTie esgenitrpn tsmsopmy ear smstoieem onyl nbclugbi nda uialpfn k.lsena Heorphtrycip htyreottaahrosop si oen fo myan tdnitas tceeff risedsdor edu to ,acrcen wthi gnlu nracce nigeb teh osmt mmonoc saceu tbu saol nriougcrc ihwt vnaraio or enrldaa clningaeaism. )b ncoerbcinogh .Ca nad eht noly werasn httsa etreals to gunl rneacc adn lla ohret sawresn do n.ot I eocsh RA, tub fi uyo 'otnd oo.n..wkwn ouy nk.ow
eTh eordretp dccnieien of aCnalp mednorys is 1 in veeyr 0100,00 .eoplep Thsi ahs bene a endgiilcn nbmeur edu ot lerow oeuexprs to l,aoc ase,btsso dan casl.ii Pervecalen of pCnala ydrneosm is ergihh in iestptan hwit iilsac eeprouxs pdceaomr to the oreht s.sauec heT tirfs ceilgeiiompod sudyt ektnnadrue yb hte onoimsieouncPs erRehasc tUni voredsbe an ideasrnec vclarepnee of AR mgtsaon emn thwi egvorriesps eimssva rsfiosib )PM(.F alMil et l.a unfdo on scdeareni reeaclepvn fo iumaredtoh trisirath in rsneim ewhn dorcamep to a nmutimyco ewerh PMF dan ahroiumdte thastirri rewe vnpeetral dan roferehet ucdecndol tath hte gyiloote fo RA saw nto etasoadsic iwht peeoxsru ot tsud ro guln shagcne of cecdpmtilao niensoipcouo.sm hreTe was a hhgi alenrpvece erta fo PFM nda obleuisrtcsu gtosnma ermins and -nerixesm with mhoedtiaru tsa]h[5r].[riti4
i:po AgaloPyhtsohyn immntuoaeu iodonicnt si a eoehnpmnon wrhee on'se bdyo hsa afoyamlimntr ellcs hwhci tkcaat ist won teussi n,ad in the ceas of ,RA the yinu.omvs It is leevidbe tath in htsee tsp,itean herte is an taoneraitl whchi escsua het ridseacen mumnei esperosn to gerofin aalmretis ni eth snlgu. rThee is ummien yvecttiirhapy that si dprseak yb ailisc in hchiw ostcmnyeo adn macgrsepoha laerees toykisnce csuh as i-n1irktneeul adn elg--umioarcgnugyaplelcottma-notoniychsar fctora nad morut snicreos atfrco hpaal. Teh rapsh gseed of the iaclis soal eaucs lyiss fo lsoasmoyl taerosesp ni ragsmapo.ceh opsheLctmyy rea cdvtaieat yb hte iycsekotn edlresea yb .pcamerogsah sihT lal elasd to an umoaeitunm ennhonomep urohhgt rxouepse to lsciai hchiw si ridteregg in yletgleican drsesiopdpe aslindudvii woh ahve RA.
ntluwdo' eth ygnnluedri dasesie eb AR which is ehtn suangci hbrcioecgnno rica?noamc 'Im ensc!fo!du
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