This patient likely has some form of upper motor neuron lesion or disease - UMN lesions are characterized by weakness, increased deep tendon reflexes, and spastic paresis. Baclofen is a GABA-B agonist specific to the spinal cord, used ot treat muscle spasticity, dystonia, and MS. GABA-B is a G-protein coupled receptor coupled to Gi, so agonism of this receptor causes hyperpolarization of the neurons and decreased release of excitatory glutamate.
submitted by โneonem(629)
This patient likely has some form of upper motor neuron lesion or disease - UMN lesions are characterized by weakness, increased deep tendon reflexes, and spastic paresis. Baclofen is a GABA-B agonist specific to the spinal cord, used ot treat muscle spasticity, dystonia, and MS. GABA-B is a G-protein coupled receptor coupled to Gi, so agonism of this receptor causes hyperpolarization of the neurons and decreased release of excitatory glutamate.