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NBME 20 Answers

nbme20/Block 3/Question#50

A 62-year-old man comes to the physician because of ...

Agonist at γ-aminobutyric acid B (GABAB) receptors

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submitted by neonem(319),

This patient likely has some form of upper motor neuron lesion or disease - UMN lesions are characterized by weakness, increased deep tendon reflexes, and spastic paresis. Baclofen is a GABA-B agonist specific to the spinal cord, used ot treat muscle spasticity, dystonia, and MS. GABA-B is a G-protein coupled receptor coupled to Gi, so agonism of this receptor causes hyperpolarization of the neurons and decreased release of excitatory glutamate.

They are talking about Baclofen, a GABA-B agonist known to treat muscle spasticity