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NBME 20 Answers

nbme20/Block 4/Question#1

A 32-year-old man comes to the physician because of ...

Tissue: testicle; Effect: estradiol production

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 +4  upvote downvote
submitted by step420(23),

B-HCG and LH,FSH,TSH share same alpha subunit, so HCG can activate those receptors if its in high enough quantity. Activating LH receptor will lead to more Testosterone from the Leydig cells. More testosterone can lead to more estrogen formation via aromatase.

dickass  bHCG directly increases testicular aromatase activity, it's not because of the increased amount of testosterone. +1  
vulcania  And for those who were wondering (cause I was), Sertoli cells have aromatase (FA 2019 p. 614) +  




 +1  upvote downvote
submitted by dickass(26),

Testicles have significant aromatase activity. This enzymatic activity is regulated by LH (and of course bHCG)

https://www.ncbi.nlm.nih.gov/pubmed/9267128





 +0  upvote downvote
submitted by divya(12),

uworld q id - 582 for reference gonadotropins increase aromatase activity.

Aromatase activity is increased by - 1) age 2) obesity 3) insulin 4) gonadotropins 5) alcohol