NBME 20 Antiplatelet antibodies (NBME Answers)

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submitted by hayayah(1081),

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drw could you also help to understand: 1) could anti-heparin-PF4 complex be also called anti-PLT antibody? 2) PLT reduction is due to both PLT thrombosis consumption and elimination in the spleen, then why hypersplenism is not correct? +

charcot_bouchard hypersplenism means bigger spleen eating everything. thats not the case here. here spleen is normal. autoimmune cause +

benitezmena Yes I dont understand why the called them Anti-platyelet antibodies and not specifically Anti-heparin bound to PF4 on platelets. Its just not the right antibody +2

benitezmena Antiplatelet antibodies would be for ITP, but also anti-megakaryocyte antibodies would also be for ITP. +1

misterdoctor69 As an aside, pregnancy is a hypercoagulable state which caused her DVT in the first place +1

cport12 If anyone else was freaking out about the word hemodilution basically it just means that there is a decreased concentration of cells and solids in the blood resulting from some other gain of fluid. With normal pregnancy (not HIT), blood volume increases, which results in a hemodilution. +1