Heparin-induced thrombocytopenia (HIT) is the development of IgG antibodies against heparin bound platelet factor 4 (PF4). Antibody-heparin-PF4 complex activates platelets thrombosis and thrombocytopenia. Highest risk with unfractionated heparin.
drwcould you also help to understand:
1) could anti-heparin-PF4 complex be also called anti-PLT antibody?
2) PLT reduction is due to both PLT thrombosis consumption and elimination in the spleen, then why hypersplenism is not correct?+2019-07-09T11:45:46Z
charcot_bouchardhypersplenism means bigger spleen eating everything. thats not the case here. here spleen is normal. autoimmune cause+2019-07-10T05:28:15Z
benitezmenaYes I dont understand why the called them Anti-platyelet antibodies and not specifically Anti-heparin bound to PF4 on platelets. Its just not the right antibody+2019-12-07T18:02:37Z
benitezmenaAntiplatelet antibodies would be for ITP, but also anti-megakaryocyte antibodies would also be for ITP.+2019-12-07T18:09:52Z
to snoo-finity ... and beyond!
submitted by hayayah(505), 2019-05-15T02:20:20Z
Heparin-induced thrombocytopenia (HIT) is the development of IgG antibodies against heparin bound platelet factor 4 (PF4). Antibody-heparin-PF4 complex activates platelets thrombosis and thrombocytopenia. Highest risk with unfractionated heparin.