NBME 20 Pathway labeled 'H' (Conversion of Leukotriene A<sub>4</sub> to Leukotriene B<sub>4</sub> (NBME Answers)

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Retired NBME 20 Answers

nbme20/Block 3/Question#6 (reveal difficulty score)
A new drug has the following effects on the ...
Pathway labeled 'H' (Conversion of Leukotriene A₄ to Leukotriene B₄ 🔍 / 📺 / 🌳 / 📖
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submitted by ∗neonem(630)

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Leukotriene B4 is a potent chemotactic molecule for neutrophils. Selective loss of this would have no effect on platelets, mast cells, or endothelium - these are more responsive to changes in TXA2, complement/arachidonic acid, and PGI2, respectively.

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kernicterusthefrog FA says: "Neutrophils arrive B4 others" +5

fatboyslim Important neutrophil chemotactic agents: C5a, IL-8, leukotriene B4 (LTB4), platelet-activating factor, and kallikrein. Source: FA 2020 page 406 +2

fatboyslim Why is choice 'C' incorrect? +

Rule out anything leading to LTC4 because mast cells release LTC4, LTD4, and LTE4 in Asthma to increase bronchial tone.

+8/- hungrybox(1277)

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