NBME 20 Decreased slope of diastolic depolarization (NBME Answers)

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Retired NBME 20 Answers

nbme20/Block 2/Question#49 (reveal difficulty score)
An 82-year-old woman is brought to the ...
Decreased slope of diastolic depolarization 🔍 / 📺 / 🌳 / 📖
tags: pharm cardio

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submitted by ∗dbg(197)

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BBs work by decreasing cAMP and Ca2+ thereby slowing SAN & AVN activity. This prolongs phase 4 of depolarization. Therefore, they are known to increase the duration of diastole (predominantly) causing both a rise in heart coronary perfusion and reduction in heart rate.

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lovebug FA 2019, 318page. class two antiarrhythmics. +1

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submitted by ∗hayayah(1212)

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Beta blockers as antiarrhythmics suppress abnormal pacemakers by decreasing the slope of phase 4 --> prolonging phase 4.

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chandlerbas piano player sliding the keys to the left ---> delays diastolic depolarization --> rate control +9

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