Type I Diabetes is characterized as the destruction of pancreatic islets (specifically beta cells) by T-cells. The most likely cause for hypoglycemia following insulin administration, therefore, is the destruction of alpha cells that surround the beta cells. This would cause decreased levels of circulating glucagon.
titanesxviI think rather that high insulin is going to block the release of glucagon+12019-10-15T14:20:54Z
According to this paper, insulin inhibits alpha cells from releasing glucagon. This is the relevant figure from the paper.
medpsychosisThere are three ways that Glucagon secretion is stimulated:
+(1) a stimulatory effect of low glucose directly on the alpha cell,
+(2) withdrawal of an inhibitory effect of adjacent beta cells, and
+(3) a stimulatory effect of autonomic activation.
The response of Glucagon to hypoglycemia is diminished in T1Diabetes. Hence in this pt, the impaired release of Glucagon allows for prolonged Hypoglycemia.
Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005043/+32019-06-16T23:23:37Z
Insulin decreases the level of blood glucose and Glucagon increases levels of blood glucose. They both counter block each other. If insulin is high glucagon will be inhibited, and when glucagon is high insulin will be inhibited. FA 2018 page 76.
to snoo-finity ... and beyond!
submitted by keycompany(124), 2019-05-29T20:52:45Z
Type I Diabetes is characterized as the destruction of pancreatic islets (specifically beta cells) by T-cells. The most likely cause for hypoglycemia following insulin administration, therefore, is the destruction of alpha cells that surround the beta cells. This would cause decreased levels of circulating glucagon.