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Welcome to prolific_pygophilic’s page.
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Comments ...

 +0  (free120#31)

Purdue Pharma bros wrote this question fer sher.

 +1  (nbme23#33)

Meme: Asian parents with a clear hemoglobinopathy, Me slapping the Alpha Thal Button

Subcomments ...

submitted by peteandplop(29),

This patient is presenting with with STEMI (FA2019 p301), thus the entire vessel must be occluded. Coronary vasospasm via a1 stimulation (increased smooth muscle contraction) would lead to these findings.

As far as the nitro aspect, I think this could be referring to pt history of ischemic heart disease, and the scenario of coronary steal, however I don't think you would need that to answer this question (and I could be going down an unnecessary rabbit hole of misery).

Other helpful pages are FA2019 p238, a1 sympathetic stimulation results in increased vascular smooth muscle contraction.

Last, big ups to the brother for setting arguments aside and still taking his hermano to the emergency department. Perhaps they were arguing at who responded to COVID-19 and medical education worse: USMLE or Prometric.

prolific_pygophilic  ^Comment of they year +1  

submitted by youssefa(130),
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I amne ywh owuld a eslitect rutn oadrun etfsil wnhe mosensoe' sege.nlpi hTsi piyyaltlc oucsrc fraet tpssor/ bcceliy indrgi .cet.

brotherimodu  People can move in their sleep? +2  
prolific_pygophilic  Actually in highschool this happened to a couple of my friends in their sleep, woke up with the sack all twisted +  

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m’I inggo to iopnt uot that a omnral tlahhey kid thiw on rcaaicd hirtyos or pmytssom dna no faiylm soithyr of dsndeu idaracc hadte for a tporssrep- aihscylp is yoabrlbp oggin to hvea a nibneg mxae on rtmtae wtah ouy kthin ouy .rhea

the260guy  What a weird question. I could definitely hear a fixed split heart sound. And it was loudest over the pulmonic valve too which makes it even more of a dirty question. But I guess what I was actually hearing was an S3 heart sound. +13  
wutuwantbruv  @the260guy I believe the splitting is being heard only during inspiration, making this normal physiologic splitting. Perhaps that's just my ears. +12  
angelaq11  don't have adobe and couldn't download it, so I just chose whatever, but your explanation suddenly makes me feel dumb but grateful! Loving your tips! @benwhite_dotcom +1  
blah  @the260guy Have to agree with wutuwantbruv. I interpreted this as a physiological splitting, had the opportunity to hear it in a newborn as well. +3  
prolific_pygophilic  Definitely S3. FA 2020 pg 287 "but can be normal in children, young adults, athletes, and pregnancy" +1  
dhkahat  I swear to god it wasnt just during inspiration but what the hell do i know +  

S2,3,4 keeps the 3 P's off the floor (Penis, Poo, and Pee)

alexxxx30  love it +1  
prolific_pygophilic  A true scholar +3  

submitted by aladar50(40),
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So sh’reet 001 denessi,rt nad eth raeenvclep earft 2 seyar is =10 at hte g,eigninbn 5+ in hte stirf e,ary +10 csndoe y,aer and -3 tath ,haelde rfo a ttalo eevlpcerna of 22 tedsnries or 202202=1/ tp.ncere ,uhsT eaceplnerv = avebo teh dratsdan. roF ci,inedcne ’ist 15 wne scesa out fo 09 seteisndr ovre eth 2 rseya 100( lotta tedsersni – 01 hatt rladaye ahd l)userc, or 51 wen lcerus erp 180 ⋅a.aeespyitntr isTh wudlo be 3.38 nwe cusler rpe 1000 artant⋅iespye if ouy xtdeteploaar it uot -- aicalybls 0/0001(8)1 * 51 -- ut,sh eiendcicn = vboea the nsdtdraa.

zelderonmorningstar  Okay I feel like an idiot cause I thought: Above the Standard = Doing a good job keeping old people from getting ulcers. Thumbs up. Below the Standard = I wouldn’t let my worst enemy into your ulcer ridden elder abuse shack. +52  
aladar50  @zelderon Ohh damn. I could totally see how one could view the answer choices that way. I think it is important to read how they are phrased - they are asking if the center is above THE standard or below THE standard. The “standard” is an arbitrary set point, and the results of the study are either above or below that cut off. Maybe if it was “above/below standards” that would work. Also, being above the standard could either be a good thing or bad thing. If say you were talking about qualifying for a competition and you have to do 50 push ups in a minute, then being above=good and below=bad. In this case, having more ulcers than the standard = bad. +4  
saynomore  @aladar Thank you!!! but how did you get the 15 new ulcers per 180 patient⋅years? I mean I understand the 15 part, but not the second part ... hence why I messed this up, lol :| +2  
aladar50  @saysomore Because the study is looking at 100 residents over a period of 2 years. Since 10 already had the disease at the start, when looking at incidence you only include the subjects that have /the potential/ of developing the disease, so 90 patients over 2 years. This would be 90 patient⋅years per year, or a total of 180 patient⋅years over the course of the study. +7  
sympathetikey  @zelderonmorningstar I thought the same exact thing. Had the right logic, but then just put the backwards answer. +3  
kai  I wonder if they chose this wording on purpose just to fuck with us or if this was accidental. My guess is there's some evil doctor twirling his thumbs somewhere thinking you guys are below the standard. +14  
symptomatology  Got it wrong!messed up in understanding options, Btw, 15/90 is somewhat 16 percent and their standerd is 50/1000 5 percent!.. this is how i knew that incidance is way up! +  
donttrustmyanswers  Patients with an ulcer are not immune to getting new ulcers --> You should include all patients at risk. But either way, the answer is the same as long as you can read NBME speak. +  
doublethinker  Damn, guess my reading comprehension is not "up to the standard" of the NBME writers. Smh. +  
prolific_pygophilic  If you forgot that its patient years (15/180) not (15/90) you still get the right answer because they are both above 5% :). +  

submitted by keycompany(308),
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eTyp I eDastbei is eeahdatrizrcc sa het dnscutierto fo ecraatncip ltssei pc(ielsfliacy atbe cs)lel by T.scl-le hTe mots kiyell ecasu rof yimheypocalg ogwnlilof ilnsuni ,tmtarindoniasi r,forteehe is teh suitnodtcer of hapal scell taht runrsuod het tabe cse.ll iThs ulodw sacue erdscadee seevll of uatrlincgic .glcngaou

titanesxvi  I think rather that high insulin is going to block the release of glucagon +6  
melanoma  the answer is not correct +1  
melanoma  his answer +1  
prolific_pygophilic  I actually think this has some merit. I believe there is a U world question that talks about how very long history of T1DM (20 years in this patient) can progress to destruction of alpha cells and hence impaired release of glucagon and episodes of hypoglycemia. Thats how I reasoned it. The first answer is also possible. +  

submitted by seagull(1539),
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ahWt a trbrieel criupte. heTy teyh droveec up ptra fo ti tiwh sneil. WFT

sympathetikey  Agreed. +14  
catch-22  Start at the pontomedullary junction and count from superior to inferiorly (or medially to laterally): VI, VII, VIII, IX. +3  
yotsubato  I looked at the left side (cause the nerves arent frazzled up). Saw 7 and 8 come out together nicely. Then picked the right sided version of 8 +11  
lolmedlol  why is it not H or I on the right side; the stem says he has hearing loss on the right side, so the lesion should be ipsilateral no? +2  
catch-22  You're looking at the ventral aspect of the brainstem. +10  
catch-22  ^Also, you know it's the ventral aspect because you can see the medullary pyramids. +1  
amarousis  think of the belly of the pons as a pregnant lady. so you're looking at the front of her +4  
hello  which letter is CN IX in this diagram? +  
miriamp3  there is no VI nerve. That's the thing. The VI nerve should be in the angle between the pons and the medulla. Parallel to the pyramid. It goes V then VII and then VIII. I make the same mistake and I thought it was the picture but there is no VI par in the photo. They know We count from superior to inferior. +  
jesusisking  Don't G and H lowkey look like VII and VIII? I chose H b/c of that +  
ljennetten  G and H are CN VII and VIII on the left side, while this guy has right sided hearing loss. CN VI is not labeled in this photo, but is the smaller nerve that arises medial to CN VII and us cut most of the way up the pons. +1  
prolific_pygophilic  Mother Fuckers took this with a disposal camera then deep fried it. What is this grainy ass picture +1  
soccerfan23  There's over a million pics of the brainstem on the internet and of course, the NBME picked the worst quality, most blurry one for this Q. +  

submitted by adong(97),

neuroendocrine cells doesn't always mean neural crest

prolific_pygophilic  you're god damn right.... kms +2