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NBME 20 Answers

nbme20/Block 4/Question#47

A 61-year-old man has erectile dysfunction due to ...

Area labeled ā€˜Dā€™ (Corpus cavernosum)

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submitted by xxabi(131),

PDE-5 inhibitors (e.g. sildenafil, tadalafil) are indicated for ED by way of increasing blood flow in the corpus cavernosum (labeled D) of the penis

dulxy071  I believe technically the answer would not be (B) as the corpus cavernosum isn't ACTED ON by PDE inhibitors ( per the words used in the question ) but rather simply fills as a result of PDE inhibitors acting on the internal pudis artery among many others to allow more blood flow into the corpus cavernosum for an erection +2  




A = Maybe the superficial dorsal vein

B = Areolar tissue

C = Urethra (surrounded by corpus spongiosum)

D = Corpus cavernosum (correct answer)

Sildenafil increases blood flow to the penis by dilating the corpus cavernosum (increased NO via inhibition of PDE5 --> cGMP --> smooth muscle relaxation). It doesn't actually affect the blood vessels supplying the corpus cavernosum, I believe