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NBME 20 Answers

nbme20/Block 3/Question#31

A 62-year-old woman comes to the physician because ...


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submitted by dickass(26),

Paclitaxel hyperstabilizes polymerized microtubules (made up of alpha- and beta- tubulin)

md_caffeiner  And clinical use is in breast and ovarian CA (FA19 433) +  

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submitted by celeste(43),

Beta-Tubulin is a subunit of tubulin. Tubulin is one of several members of a small family of globular proteins. It is the major constituent of microtubules. There are two of most common members of the tubulin family: alpha-tubulin and beta-tubulin, and together their dimers form microtubules. (origene.com)

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submitted by xxabi(131),

Vinca and plant alkaloids bind B-tubulin, which inhibits the formation or disassembly or microtubules, respectively.

md_caffeiner  Vinca is a plant alkaloid and it has vinblastin, vincristine, which bind β-tubulin and inhibit its polymerization into microtubules Paclitaxel hyperstabilizes and prevents breakdown, its not a Vinca alkaloid. (FA+Wikipedia) +  
md_caffeiner  What I mean is they are both derived from plants. +