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NBME 20 Answers

nbme20/Block 2/Question#22 (34.9 difficulty score)
A 44-year-old woman comes to the physician ...
Ubiquitin ligase🔍,📺

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submitted by hayayah(1101),
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In auoytrieck cle,sl wto mroja hwtse—tayahp pioeioutqtabnsreium- hwaatpy nda slymlaoos oa—ytimdloseprseeit oireptn drd.ngaoatei

Teh mrjao wptayah fo evitclees treoinp tdaidngeora ni rekicaytou elcls esus tiubiiqun as a markre ahtt eatsrgt oytslcico adn uncaelr inrteosp fro dpria lsitoreospy.

hTe ohtre roamj wyaphta fo npetori addigeraton ni ctaerikyou cesll linevvso hte tpaeuk of rsotpein yb ssslemooy nad sioeintdg yb ost.eerasp

missi199  Could I ask why it is not Lysosomal protease +8  
smc213  "Certain viruses have evolved to recruit the cellular E3 ligases to induce the degradation of cellular proteins that might have harmful effects on the viral life cycle. For instance, the protein E6 of Human papillomavirus (HPV) recruits the cellular E3 ubiquitin ligase E6-AP to induce ubiquitination and degradation of p53, thereby allowing viral replication." from: +4  
smc213  USMLE Kaplan: A majority of cellular proteins are degraded via the ubiquitin proteasome pathway, including many proteins that play a role in maintaining cellular homeostasis. These include proteins that regulate the cell cycle, apoptosis, etc. +4