welcome redditors!to snoo-finity ... and beyond!

NBME 20 Answers

nbme20/Block 1/Question#7

A 5-year-old girl with AIDS develops a progressive ...

Thymidine kinase

Login to comment/vote.

 +5  upvote downvote
submitted by hayayah(422),

Acyclovir, famciclovir, valacyclovir are guanosine analogs. They undergo conversion to acyclovir monophosphate via virus encoded thymidine-kinase. Ultimately, they inhibit viral DNA polymerase by chain termination.

Mutated viral thymidine kinase can cause resistance.