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NBME 15 Answers

nbme15/Block 4/Question#29 (reveal difficulty score)
A previously healthy 27-year-old woman is ...
Superantigen activation of T lymphocytes ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1780)
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This is staphylococcal toxis shock syndrome, commonly associated with tampon use or nasal packing (as in this case). TSST1 (toxic shock syndrome toxin) is a superantigen that nonspecifically activates T-lymphocytes by binding to MHC II and the TCR. (FA2020 p135)

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submitted by โˆ—specialist_jello(31)
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H/o nasal polypectomy

  • Must've had to put nasal packing

  • Must've left it in too long

Staphylococcal TSS after Tampons and Nasal packing.

  • MOA : Superantigen activation
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submitted by โˆ—prostar(22)
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Lipase degradation of lipids- C. perfringens

Toxin-B mediated cleavage of desmoglein-1 = Exotoxin of S aureus that causes SSSS

Alpha toxin mediated depolarization of plasma membrane - C difficile

Leukocidin-mediated lysis of phagocytic cells- PV toxin of S aureus

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