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Retired NBME 15 Answers

nbme15/Block 4/Question#31 (reveal difficulty score)
A 50-year-old woman comes to the physician ...
Endothelin ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1781)
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This woman has pulmonary hypertension, likely pulmonary arterial hypertension characterized by increased pulmonary artery pressure with a normal pulmonary capillary wedge pressure (remember pulmonary capillary wedge pressure is associated with left atrial pressure). PAH endothelial dysfunction causes an imbalance in vasoconstrictors (such as endothelin) and vasodilators (NO and prostacyclin). [FA2020 p679]

BosENtan, used to treat PAH, is an ENdothelin antagonist (FA2020 p686)

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cheesetouch  FA0281 p667 +
scoresloth  I thought it was a prostacyclin analog. +



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