theres a uworld question like this ... ,, rivoraxaban and other factor Xa inhibitors prolong pt and aPTT but they dont affect thrombin time ... while direct thrombin inhibitors prolong PT aPTT and Thrombin time , also unfractionated heparin prolongs aPTT and Thrombin Time (Theoreticallly it should prolong PT too but in the test the PT reagent contains heparin neutralizers that minimize this effect ) . sorry if this veered off course a little
Could someone explain to my why it is Factor X? Like I understand that PTT and PT are both elevated. I picked Factor X and then changed it to "hydrolysis of.." because I thought with a Factor X deficiency, wouldn't you have a prolonged thrombin time? I might be making this more complicated, but doesn't Factor X play a role in thrombin activation, so lack of it would lead to a prolonged thrombin time?
https://www.google.com/search?q=what+does+thrombin+time+evaluate
The
thrombin_time
evaluates that part of the hemostatic process where soluble fibrinogen is changed into fibrin threads. It measures the time required for a fibrin clot to form following the addition of a standard amount of thrombin to plasma.
(emphasis mine)
i did this through elimination:
a,c and D intrinsic; โPTT only
B) which is actually the PIP2; involved in Gq signaling
submitted by โmcl(671)
Not sure if this is the right way to think about it, but if PT and PTT are both prolonged, this most likely means there is a problem with the common pathway (aka factor X).