Loop diuretics are first line for acute congestive heart failure. That should help you remember that they are the most potent diuretics, so they're often used in the acute treatment of edema.
Furosemide and other loop diuretics are indicated for use in volume overload secondary to renal failure. Recall loop diuretics inhibit the Na+/K+/Cl- pump at the thick ascending loop of Henle, which messes with the hypertonicity of the medulla and therefore prevents urine from being concentrated. This results in increased fluid loss to urine, and is helpful in treating symptoms of edema.
Chronic renal failure = High potassium in blood (page 590 FA19) Furosamide is the strongest diuretic on that list that also depletes Potassium
furosemide is the DOC for fluid over flow (i.e. HF) but i cucked myself by overthinking
CKD = hypocalcemia. furosemide = more hypocalcemia. hydrochlorothiazide = get to keep the Ca2+ babies. chose thiazide with a smile on my face, but didnt last long
Loop diuretics are 90% bonded to proteins and are secreted into the proximal convoluted tubule through organic anion transporter 1 (OAT-1), OAT-2, and ABCC4. Thus, there use is not dependent on GFR.
Thiazide diuretics are filtered via the glomerular apparatus, thus their use is dependent on GFR.
Use loops during low GFR states. Use thiazides in normal GFR states (to prevent compensatory Na/Cl reabsorption at the distal tubule when using a loop).
https://en.wikipedia.org/wiki/Loop_diuretic
submitted by soscrying(11)
at my uni, we learnt that at lower GFR, loop diuretics still work. That's why you should use them in renal failure. Thiazides would not work with a GFR of <30.