I think the idea here is simply that one should think about where vesicles are coming from on their way to the golgi complex.
"Two steps forward and one step back." Specfically the question may be referring to a rare craniofacial disorder. an awarenesss of that disease is not necessary. What is necessary is understanding the origin from where vesicles are traficked to the Golgi apparatus.
COPI protein is needed to coat vescles from the RER to send to golgi. Thus, with a mutation in that protein, the packaged proteins that should bleb off and be sent to the golgi, instead accumulate in the RER and dilate it. Thus the answer.
hayayahpg. 47 on FA got the good visuals! +22019-05-20T17:04:22Z
notadoctorCOPII* proteins are needed to coat vesicles from the RER to Golgi. "Two(COPII) steps forward; one(COPI) step back."
Anterograde goes RER -> Golgi -> Lysosomes/Secretory Vesicles -> Plasma membrane+132019-06-10T18:05:15Z
titanesxviwhy not small lysosomes?+22019-08-14T19:20:50Z
varunmehruand I thought large lysosomes due to lack of enzymes to degrade +2019-08-24T16:19:34Z
samsam3711The size of the lysosome is not affected by the presence or absence of protein, but its function is compromised (eg. protein is getting stuck in the RER)+2020-01-07T17:45:37Z
fattyacidI hope this helps to whomever was lost like me
Null mutation: A mutation (a change) in a gene that leads to its not being transcribed into RNA and/or translated into a functional protein product. For example, a null mutation in a gene that usually encodes a specific enzyme leads to the production of a nonfunctional enzyme or no enzyme at all.+12020-01-18T12:20:24Z
to snoo-finity ... and beyond!
submitted by sklawpirt(19), 2019-05-18T20:59:48Z
I think the idea here is simply that one should think about where vesicles are coming from on their way to the golgi complex.
"Two steps forward and one step back." Specfically the question may be referring to a rare craniofacial disorder. an awarenesss of that disease is not necessary. What is necessary is understanding the origin from where vesicles are traficked to the Golgi apparatus.
COPI protein is needed to coat vescles from the RER to send to golgi. Thus, with a mutation in that protein, the packaged proteins that should bleb off and be sent to the golgi, instead accumulate in the RER and dilate it. Thus the answer.
https://www.cell.com/ajhg/pdf/S0002-9297(16)30214-2.pdf