heT eienweravL uBrk olPt si ymlnai rdtreetnepi yb ist X and Y episTt .rtchnee sequonit saetts hatt gnviig 6B eainressc hte vyciitat ot onrmla ,lelesv hciwh measn teh ayvtciti loudhs eb the ames as het ,lmeHrnca.n eo hetri Y iecrpttne odlsuh eb teh sam,e so ew rea neweebt oceshic B and C. A dan D do ont hvae eth emas Y ireenptct as orimnre.g ahlH ocnoritsnnatec of B6 sedacu ivictyta ot ebecmo mnaorl, nad so maxV llwi not be ginaghcn adn ew can cnelac A nda .AD sha a orwel maVx and D has a ucmh irehhg haV .Tmex eefcfdrine ewnteeb B nda C is ni etirh K.m gviMon ot eth felt on eth X xisa smkae eht mK rlewo dna tlesl uoy ahtt nififyat is e ghihosr uoy lduwo ont deen roem .6B tuB ni uor seca atiffyin fo eht meyzne fro B6 si erllya lo,w whhic is hwy we deen a ont rome 6B.
nI a,mrsyum we nwta teh eams Vxma nda a herihg m.eWK ntaw eht an"ol"mr cvyiitat e(ams xavm sa ln)roam adn ew dnee rhghie mantsuo fo B6 ofr suecssc aifsfyinot of eth eemnzy fro 6B si rybpalob ervy l.wo
hCceoi B ash a )/1Km(- vuael locrse to 0 whhci msaen mK is olwer dan niatfyif fo eht mzneye fro its rtesbaust si erpsu hilTo. ws ksame esens as gniivg ehhirg tamnuos fo eth pttieoci"vme" suebrsatt 6B is lip.gehn
iedNnge h"geirh "ocesnattonncir fo hte 6B for emyzen iavictyt si tnaeorh way fo ygnias mK is rgeihh niesc rmeo si rrueqide ofr /21 amvx ytci.tvia adcrIseen Km vsleua luerst in /m1K bigen lrlmaes slco(er ot 0 on the ,xis)ax- chhwi si retesomanddt in nwrsea ioehcc B.
A m"ral"no mezney aitctivy ni eht resnecep fo gihher 6B ocietnnrtacnso nsmae that xaVm is not nahgncgi, tub mK i.s
oSme fo ehste saapixtenonl yallre dngoi teh m.ost fI het zmeney si bale to nesciare to nlaorm iictvtya tiwh a ihgehr eelvl fo the ,bssrutaet htat esman ’ewer ni a pimtetoevic ihiortbni tinos.iatu Cpiemetvtio laasyw csrssoe on eht a,hrpg so ew acn etnmeliai A dna D.
oNw we nyalaez Km. We nwta sllam msK’ rfo entpto ezes.ymn Siez sode ton walyas etatmr .😉 etcpxE ni tish scea ew tdn’o antw htat cnpy,oet we twan to oolk for a l1y/e(ral igb K,)m auv(le tath is slcroe ot eo,r)z cb ew tawn a awek bgi Km ot eb abel to reoovepwr eht itevpiocmet iot.nbhrii Crapnigom eht giarneinm 2 escch,io B sha a mK aulve oscerl to rzoe os erse’ht uyor n.warse
oFr tish ,nieqsuot I was iktnnigh taht htey kased ouy mcpoear ot a lr”moan“ oe,prsn os hte xVma odt’wuln hcegna cnesi heyt taets ttah sih iivactyt rurtens to a mnaorl l.eevl ynlO het isax-x luodw nisce ti uoldw eb at dcrniseea csnatrenonitco ni nrs.paimooc
So i fduno itsh eotuiqsn cd.oulir.u.si eht nxstoleiaanp rvodidpe did nto lylear relac ti up ofr e,m tbu i tknih i nstdreaund ti won seapel( ectorrc em fi im' w.)orng
rtiFs nda mes,torfo 'Im ton enev uesr if itsh is urlyt a veiee-bwunarrlke ,tpol esicn hte Xaxs-i is ton ./K1m
tB,u rmoe glrn,ayele I tierd to annduertsd twha enppaedh ta btoh eserxetm fo LPP[] dna ole.Vytic
s:PAkLP e:ulosyfr eherw no teh aphgr si ]P[LP e?sigthh ,eWll if het xi-asX is uqael to ,PL/1P PLP owdul eb at its stiehhg at teh avleu sotecsl ot 0 on het xai-xs. (knit:h waht si 1 videidd by a lbioinl? ERVY CSOLE OT R.)ZEO This udlwo ecnrsodopr to a itnpo onlag het -syxia orf the zseemyn ctyiiat.v In threo ,drwso LPP is at tsi ehtigsh ttnnainroceco at eth harpsg p.incrt-teeY
merbReem thaw we saol s:dia wnhe eht teduatm yzmeen si rdanou tols of ,LPP ti aiblasycl ciuotnnsf leki a lmn .ezeynm This n,maes hatt teh maVx of hte mtdeuta yzemne si evqeitalun to teh Vaxm fo hte namorl ymz.nee ,ereeorhfT Teh 1xma/V fo both enmszye era tnvee.ai.uql. ta hte ipseictn!h-erTty si gi!b fI yuo egt siht ra,f ethn uoy anc niliaeetm (A) adn )(,D isnce seeht srphga heva firfdetne rnptict-seeY nft(edrefi Vme-x)sa rof tirhe ceivtepers y.eenzms
vigonM ..o.n
Viyltcoe :)V( Weh n V si ta tsi sithegh (i.e. ma),xV eth auelv of /1V dlwuo be ta tis e.lwsto a:iA(ng tnhki of it acracpiltl:y hawt si 1 didvdei by 1 ?lniboil )0!~ Tere,rfoeh eht eualv fo /V1 is at tsi owlste nweh the x-yais si eaulq to .0 hrToeee,fr eTh xVma fo siht rsccuo whne hte -isaxy is locse to ...zeor eHers het hingt oth.. etehs zsyenme ruqiere tfndreife lelsev fo PPL to peortae ta am-.Vx ,bmermeRe the Vmx-a fo the UDEATMT nyzmee llwi pnapeh at a mhcu IRGEHH P].LP[ rO ensor,ecyvl eht a-xmV of eth NAROML enmyze ilwl hpenap ta a umhc ROELW PL.P.[].
eb wraea ttah eth xaxs-i orf hist onsuteqi is nto K"m" B(t6iv si not teh tebustaatsr th' /t6BiV]1[. ot pyi,mfsi uaesbce hte xamV si angon asyt hte ,aems ouy ustj dnee to eansicre tBi[v6] to tge the meas xmVa a(ak tihfs to hrtig on teh ixx)s.-a oD'n t eb lodeof odunra by eth untieoqs tre.irw
bdyNoo ash wranesde tish oiuntesq togrhhu het esnl of a rinagenl vijectebo qtiue tye so rhs'ee ym 2 stcne: Km si EDNACSRIE bc shit pttinea has na nmeeyz tihw an elavlro WLEOR nafyfiit nca( eb rceertodc ot alrmon terfa an aeescinr ni etb)suasrt chwhi si catartcsirhice of ETICOMVITEP itn,bhiioin iwhhc is hwy hte lein of eth p.t is eno of tiicmevopet nhiiibntoi no a LB oltp
hTe itenoqsu is aslicybal sntiegt up a tisuoaint rsiialm ot atht of a copvtiimeet .nribhotii eyhT yas atth ehgirh tosrtcoecnnina fo lriypdoax teoaphhps nasreices teh taviicyt of eth yzemne ot alnorm le.vesl llyriim,aS wneh you eavh a epmicevtiot ohiintibr adn escreina eht cottnaiecnrno of ssaet,rtbu hte yeznem acn vieecah eth aesm mVxa sa fi thowtiu eth hiibrntoi.
mrebemeR 1 ) tcioievptme niithsibro ~ lnesi sosCr ta itsen2c)-yr te -oeNempctinotiv ihbiironts ~ no ilen corss
Lnog eswanr hdea,a tub rbea itwh em.
I:TNH v skloo inkd fo leki ,y ewaerhs k kolso omer ekli .x
etti-precyn = Vm1x/a
rtcxpnt-eei = /mK1
Note thta ,Vmax sa a sraemeu fo nefmpcaroe,r cna be terldea huhtgor aymn .ihntsg elne,ahiwM Km si a tse reaisathctricc of teh ezeym,n and nancto eb teadr.le
In tshi ep,lmaex eht emnezy mfrenpeacor )Vx(ma si rniesdace by ncsiinareg het iivtmna rofctoca os atht it areeshc a mrn"ola" vaicyt.ti H,eeovrw eht zmeyne is ltsil yeirhnelnt tihtsy deu ot a ongnteacli etdcf,e os eht Km tyssa teh e.ams
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