I was so fixated on the fact that in a TB granuloma, macrophages produce IL12 or TNFalpha, not IL1. So I eliminated C and clicked B, even tho it’s not CD4 lymphocytes that produce TNFalpha. But the fact that macrophages produce IL1 still didn’t make any sense.

I couldn’t find any explanation in first aid for this (it doesn’t tell you what cells secrete IL1), but according to my notes from an immuno lecture I half paid attention to, IL1 is a cytokine of innate immunity secreted by monocytes, macrophages, endothelial cells, and epithelial cells; so basically everybody. This goes in conjunction with everything that FA says (FA18 p. 108)

IFN y will inhibit differentiation of Th2 cells and therefore (a,e wrong) b) regulatory T cells d) if the case was talking about virus

interferon gamma will do a few things in body--> 1 activate macrophages to kill! or to become epitheliod histiocyte to wall off infections. 2- it will increase the mac molecules on the surface of the cells. 3. it inhibits differentiation of t cell to th2 cell because th2 has anti inflammatory (il-10 secretion) and eosinophilic activation function. 4. also activated the nk cells to start killing!

IFN gamma stimulates macrophages to produce granulomas