NBME 21 Answers : Block 1 : #12 = A 25-year-old nulligravid woman comes to the ...

+2 upvote downvote
submitted by mcl(218),

PCOS is associated with abnormal production of sex steroids, including dysfunction of estrogen production and progesterone. Chronically elevated levels of estrogen can cause endometrial hyperplasia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917599/

meningitis Why isnt it endometriosis? Could someone help me out on this? +

meningitis Sorry, I was confusing with higher risk for endometrial carcinoma. +

vi_capsule Estrogen is responsible for cyclical bleeding and pain associated with endometriosis hence progestin is a treatment modality. But estrogen isnt a risk factor for Endometriosis. Rather theres retrograde flow, metaplatic transformation etc theories are responsible for endometriosis. +

sympathetikey Tfw you get so thrown off by a picture that you don't read the question properly. +2

hyperfukus @meningitis idk if u still care lol but always go back to endometriosis=ectopic endometrial tissue outside of the uterus so you can rule it out since increased estrogen would cause you to have worsened endometriosis or a thicker one but not directly...you can see the clumps of the follicles in the ovaries if you look super close so that along with the presentation takes you to PCOS and anytime you don't have a baby or stay in the proliferative phase(estrogen phase) you get endometrial proliferation-->hyperplasia--->ultimately carcinoma +