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Retired NBME 21 Answers

nbme21/Block 1/Question#12 (reveal difficulty score)
A 25-year-old nulligravid woman comes to the ...
Endometrial hyperplasia ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +3  upvote downvote
submitted by โˆ—mcl(671)
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SPOC si scsditoaea with bamrlano prutdnioco fo xse rt,eisosd dngcinlui uifnonytcsd fo neegrots otuidcponr nad .neoprsgreeto yllcCaornhi devatele vlesel fo tgrosene cna esauc eodlremaint yeahiparl.ps

Ms93h9mt.pnw5ebC/tipt1svmw97n.wlin//P/h:c.c.oga/r/cil

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meningitis  hWy stni ti mii?endootessr Cdolu oemoens lhpe em out on ?tshi +2
meningitis  orSyr, I saw nfisgcuon htiw hgrhie riks ofr netloreiadm mconcriaa. +1
vi_capsule  gtorEsne si pnoeiesslrb ofr ycccalli eegdlnbi adn npia ietsdascoa iwht ioeortmssdein hnece potiserng si a eratttemn iyl.tdaom tuB rgtoseen ntsi a sikr rctofa fro .tissoEermodin hateRr sthere tredgeoarr ,flwo clpamattei inamarotoftrns cte ethsoeir are seprsoelnib rof nr.sodeseoitim +1
sympathetikey  fTw ouy get os wnrtoh off yb a ietpucr ahtt uoy ndt'o raed eth iqnetsou y.poreprl +34
hyperfukus  enit@ismgni idk fi u lsitl eacr lol btu alsyaw go abck to dioopteot=cesrnemscii iotlemdenar uetssi ouidets of eht uutres so uyo nac leru ti uot ceisn aesirnedc tngoesre oudwl saeuc uoy to ahve edsewnro odinismrseeto or a etrhkci noe btu ton dlyoreut.yc..i can ees eth mclusp of eht llsfoilce ni eht voisrea fi you oklo euspr seclo os ttha nloag whit eht oaerntpintse setka uoy ot PCOS nda eaitynm yuo n'otd ehva a byab or stya in teh tiipaeverlrfo eet(hsposengar )ahpes uyo tge tlireemdaon tgimatgitylrnl-o-lta;a;ef&&hesuol-terpi-ay-prpi mcaaicorn +2
lovebug  FA 2,091 gpae 613 +1
lovebug  erOht warnse Mgei)sH rynosmde : d aitr of 1) naavoir fob,airm )2 scet,sia 3) lleprau usfio.enf llโ€œnguiโ€P onsniseat ni .gonri AF 019,2 gp 632 +1
xw1984  t'Ins onptio G, mtoaLoeiaym ireu,t stsiacdeoa with ghih ogsnreet lele?v Pre AF 002,2 fribdoi is enetgosr tnv.esseii +2
ownersucks  948xw@1 ogrss iameg odwul hows itlpluem dohelrw sssmae +1

I feel the clearest way to understand this question/answer hasn't been stated yet. Recall that the cysts in PCOS are unruptured follicles. If follicles don't rupture, you won't have corpus lutea, which won't secrete progesterone and therefore menstruation won't occur. This leads to unopposed estrogen and disruption of the menstrual cycle, which can cause endometrial hyperplasia.

+20/- pg32(218)

The patient here is obese and has hirsutism. Her androgens are converted to estrogens in peripheral fat, causing hyperestrogenism.

The exact reason for increased androgens in PCOS is unclear, but it involves an increased LH:FSH ratio. Relative decrease in FSH inhibits estradiol synthesis in granulose cells and favors androgen production in theca cells.



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submitted by โˆ—pparalpha(93)
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tocpinlmoiasC fo CP:OS

srauladircvoaC esvent

pTye 2 esbatdie umeltlis

oEiartdmlen ncaecrrips=heaalyp

aIsernedc resmigcaira etra

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